Bizoran 5/20mg Tablet

Uses of Bizoran 5/20mg Tablet

• Treats High Blood Pressure

How does Bizoran 5/20mg Tablet work?

Bizoran 5/20mg Tablet is a combination of Amlodipine and Olmesartan. Amlodipine works by relaxing your heart muscles and blood vessels so that blood can flow more easily. Olmesartan relaxes and widens your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood throughout your body.

Side Effects of Bizoran 5/20mg Tablet

• Body pain
• Headache
• Chills
• Nasal congestion
• Unusual tiredness and weakness
• Blood in urine
• Joint pain
• Swelling of feet or lower legs
• Diarrhea
• Dry mouth
• Increased urination
• Skin rash
• Difficulty in breathing
• Increased heartbeat
• Upset stomach

Quick Suggestions:

• Olmesartan Medoxomil + Amlodipine is a combination of two medicines that provides better blood pressure control than either medicine alone.
• It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
• It may cause you to feel lightheaded or weak especially when you stand up.  Rise slowly if you have been sitting or lying down.
• Avoid consuming alcohol as it may enhance the blood pressure-lowering effect of Olmesartan Medoxomil + Amlodipine.
• It can cause ankle or foot swelling. Raise your legs while you are sitting down and talk to your doctor if it does not go away.
• Do not take Olmesartan Medoxomil + Amlodipine Tablet if you are pregnant, planning to conceive, or breastfeeding.

Indication of Bizoran 5/20mg Tablet

Bizoran 5/20mg Tablet is an angiotensin 2 receptor blocker (ARB) used to treat high blood pressure. It can be taken once daily, with or without food, as directed by your physician. Maintaining optimal blood pressure levels is important for preventing kidney disorders, strokes, and heart disorders. Please follow your doctor's instructions carefully when taking this medication.

Pharmacology

Amlodipine is a calcium channel blocker that works by inhibiting the entry of calcium ions into vascular smooth muscle and myocardium. This leads to vasodilation of peripheral arteries, reducing peripheral vascular resistance and lowering blood pressure. Its effect on vascular smooth muscle is greater than its effect on cardiomyocytes.

Angiotensin II is a potent vasoconstrictor and a key hormone in the renin-angiotensin system. It is formed from angiotensin I by the action of angiotensin-converting enzyme (ACE). Angiotensin II also stimulates the release of aldosterone from the adrenal cortex. Aldosterone promotes sodium and water retention, leading to increased blood volume and elevated blood pressure.

Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to AT1 receptors found in various tissues, including vascular smooth muscle and the adrenal glands. By blocking the vasoconstrictive and aldosterone-secreting effects of angiotensin II, olmesartan Medoxomil helps to relax and dilate blood vessels, reducing peripheral vascular resistance and lowering blood pressure. Unlike ACE inhibitors, olmesartan Medoxomil does not inhibit ACE, the enzyme responsible for converting angiotensin I to angiotensin II and breaking down bradykinin.

In summary, Amlodipine and Olmesartan Medoxomil work together to lower blood pressure by different mechanisms. Amlodipine inhibits calcium entry into vascular smooth muscle, leading to vasodilation, while olmesartan Medoxomil blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to AT1 receptors.

Dosage & Administration of Bizoran 5/20mg Tablet

The recommended initial dose of Bizoran 5/20mg Tablet for hypertension is 5 mg amlodipine and 20 mg olmesartan once daily. The dose may be increased after 1-2 weeks of treatment if needed, but the maximum recommended dose is 10 mg amlodipine and 40 mg olmesartan. It can be taken alongside other antihypertensive agents.

For elderly patients, a lower starting dose may be considered. In patients with mild to moderate hepatic impairment, caution should be exercised.

It is important to follow your physician's instructions and take Bizoran 5/20mg Tablet as prescribed. Swallow the tablet whole with a glass of water and do not crush or chew it. The dose and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific condition being treated.

Interaction

Bizoran 5/20mg Tablet may interact with various medications and substances. Some of the drug-drug interactions include interactions with high blood pressure medications, lipid-lowering drugs, medications for erectile dysfunction, antibiotics, antifungal drugs, anti-HIV drugs, anti-epilepsy medications, immune-suppressing drugs, and painkillers. It is important to inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

There are also drug-food interactions to be aware of. Grapefruit, grapefruit juice, and St. John's wort should be avoided while taking Bizoran 5/20mg Tablet as they can interact with the medication.

In terms of drug-disease interactions, Bizoran 5/20mg Tablet should not be given to individuals with cardiogenic shock, heart valve problems (stenosis), low blood pressure (hypotension), liver disease, or heart failure. It is important to discuss your medical history and any underlying conditions with your doctor before starting this medication.

Contraindications

• If you are allergic to Amlodipine or Olmesartan Medoxomil or any other ingredients of Bizoran 5/20mg Tablet.
• If you have diabetes or some kidney issues and are taking medicines containing Aliskiren to treat your high blood pressure.
• If you suffer from any heart conditions like shock, irregular heartbeats, heart attack, low heart output, etc.
• If you are pregnant for more than 3 months.
• If you have problems with your liver.
• If you have low blood pressure.

Pregnancy & Lactation

Pregnancy category D. The combination of Amlodipine and Olmesartan Medoxomil should not be used in the second and third trimesters as it can cause fetal death. When pregnancy is detected, this combination should be stopped as soon as possible. It is not clear whether olmesartan and amlodipine are excreted in human milk. Due to the possible adverse effects of breastfeeding babies, the decision should be based on the importance of the drug to the mother whether to stop breastfeeding or to stop taking the drug.

Precautions & Warnings

• Bizoran 5/20mg Tablet should not be given to individuals who are allergic to Bizoran 5/20mg Tablet or any of its ingredients. It should also be avoided by those with low blood pressure (less than 90 mm Hg), a history of heart attack, kidney disease, or liver disease, and in pregnant or breastfeeding women. Additionally, it is contraindicated in cases of low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem).
• Bizoran 5/20mg Tablet can pass into breast milk, although its effect on the baby is not known. It is important to inform your doctor if you are taking Bizoran 5/20mg Tablet and breastfeeding.
• Grapefruit juice and St. John's wort should not be consumed when taking Bizoran 5/20mg Tablet as it is contraindicated. These substances can interact with the medication and affect its effectiveness or increase the risk of side effects.
• Finally, it is advisable to avoid consuming alcohol while using Bizoran 5/20mg Tablet as it can cause low blood pressure. It is best to follow your doctor's advice regarding alcohol consumption while on this medication.

Storage Conditions

Store at room temperature away from light and moisture. Do not store it in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed