Vigore 100mg Tablet

Uses:

Erectile dysfunction (impotence), Pulmonary arterial hypertension

How does Vigore 100mg Tablet work?

The drug relaxes the smooth muscles by inhibiting Phosphodiesterase type-5. This results in the increase of cyclic guanosine monophosphate (cGMP) which relaxes the smooth muscles and increases the flow of blood.

Side Effects of Vigore 100mg Tablet

• Headache
• Nausea
• Dizziness
• Indigestion
• Stomach upset

Quick Suggestions:

• Striving for a healthy body weight and lifestyle can have a positive impact on managing erectile dysfunction.
• Consuming a well-balanced diet rich in essential nutrients can promote overall health, which can benefit sexual function.
• Engaging in regular physical activity is beneficial for cardiovascular health, which plays a critical role in erectile function.
• Reducing or avoiding alcohol intake is advisable, as alcohol can temporarily impair the ability to achieve an erection.
• Refraining from tobacco use is essential, as smoking can contribute to the development of erectile dysfunction.
• Nurturing an intimate and supportive relationship with your partner can positively influence sexual well-being.
• If Vigore 100 Red Tablet 4's is prescribed for erectile dysfunction, do not take it more than once a day.
• In the event that an erection persists for more than four hours after sexual intercourse, consult your healthcare provider, as this could be a sign of a medical condition known as priapism, which requires prompt attention.

Indication

Treatment of Erectile Dysfunction (Impotence) in Adult Men: This medication is used to address erectile dysfunction in adult men. It achieves this by relaxing the blood vessels in the penis, which allows for an increased blood flow into the penile region when the individual is sexually aroused. It's important to note that Vigore 100 Red Tablet 4's assists a person in achieving an erection only when sexual stimulation is present. It does not create an erection on its own but enhances the body's natural response to sexual arousal.

Management of Pulmonary Arterial Hypertension (High Blood Pressure in the Lungs) in Adults: Vigore 100 Red Tablet 4's is also used to manage pulmonary arterial hypertension in adults. In this context, it relaxes the blood vessels in the lungs, leading to an improved blood supply and a reduction in the heart's workload. This helps in the treatment of pulmonary hypertension, improving the individual's ability to engage in physical activities and slowing down the clinical progression of the condition.

Erectile Dysfunction (ED):

Erectile dysfunction refers to the inability to achieve and sustain a firm and erect penis suitable for sexual intercourse. It can be triggered by physical or psychological factors, such as fear of sexual performance, anxiety, depression, low self-esteem, or stress. Additionally, certain lifestyle choices like smoking, excessive alcohol consumption, obesity, physical inactivity, and high blood pressure can contribute to the development of erectile dysfunction. Common symptoms include difficulty in attaining an erection, struggling to maintain an erection during sexual activity, and a reduction in sexual desire.

Pulmonary Arterial Hypertension (PAH):

Pulmonary arterial hypertension is a condition characterized by elevated blood pressure in the arteries of the lungs and heart. It occurs when these blood vessels become narrowed or obstructed, increasing the workload on the heart. Symptoms of PAH encompass chest pain, dizziness, fatigue, and swelling in the legs and ankles.

Pharmacology:

• Sildenafil functions by inhibiting phosphodiesterase type-5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum.
• Inhibition of PDE5 leads to increased levels of cGMP, resulting in smooth muscle relaxation and increased blood flow to the corpus cavernosum, facilitating the process of achieving and maintaining an erection.

Dosage & Administration

Adult Dose:

For Erectile Dysfunction:

• The typical adult dose is 50 mg taken approximately 1 hour before sexual intercourse.
• The dosage may be adjusted based on penile response, with a maximum dose of 100 mg per dose.
• It is not recommended to take more than one dose within a 24-hour period.
• For elderly individuals (age >65 years), a lower initial dose of 25 mg is recommended.
• Individuals with hepatic impairment should start with an initial dose of 25 mg.

For Pulmonary Arterial Hypertension:

• The recommended dose for pulmonary arterial hypertension is 20 mg, to be taken three times daily.
• These doses should be administered 4-6 hours apart.

Renal Dose:

• In cases of renal impairment with a creatinine clearance (CrCl) less than 30 ml/min, the initial dose should be 25 mg.

Interaction

Drug-Drug Interactions:

• Nitrate Medicines (Nitroglycerin): Combining Vigore 100 Red Tablet 4's with nitrate medications can lead to a significant drop in blood pressure, potentially causing serious health issues. Nitrate drugs are often prescribed for chest pain (angina).
• Guanylate Cyclase Stimulator (Riociguat): Co-administration of Vigore 100 Red Tablet 4's with riociguat can lead to a dangerous decrease in blood pressure. Riociguat is typically used to treat pulmonary hypertension.
• Protease Inhibitors (Ritonavir): Certain medications, such as ritonavir (a protease inhibitor used in HIV treatment), can increase the concentration of Vigore 100 Red Tablet 4's in the blood. This could potentially lead to an increased risk of side effects.
• Anti-fungal Medications (Ketoconazole, Itraconazole): These antifungal drugs can increase the levels of Vigore 100 Red Tablet 4's in the blood, potentially intensifying its effects and side effects.
• Alpha-Blockers/Anti-Hypertensive Medications: Combining Vigore 100 Red Tablet 4's with alpha-blockers or other antihypertensive drugs may lead to a drop in blood pressure, which could result in dizziness, fainting, or other adverse effects.

Drug-Food Interactions:

• Heavy Meals: Taking Vigore 100 Red Tablet 4's after a heavy meal may delay the onset of its effects. To experience faster results, it is recommended to take this medication with lighter meals.
• Alcohol: Alcohol consumption is discouraged while using Vigore 100 Red Tablet 4's, as it can temporarily impair your ability to achieve and maintain an erection. Combining alcohol with the medication may diminish its effectiveness.

Drug-Disease Interactions:

• Heart Problems: If you have a history of heart problems or are at risk for cardiovascular issues, consult your doctor before using Vigore 100 Red Tablet 4's, as it can affect blood pressure.
• Blood Circulation Problems: Conditions that affect blood circulation may interact with this medication. Discuss any such issues with your healthcare provider.
• Stomach Ulcers: Inform your doctor if you have a history of stomach ulcers, as Vigore 100 Red Tablet 4's could potentially exacerbate this condition.
• Bleeding Problems: Conditions that affect bleeding tendencies should be disclosed to your healthcare provider, as the medication may interact with these conditions.
• Penis Deformity or Peyronie's Disease: Individuals with penis deformities or Peyronie's disease should exercise caution and seek medical advice when considering the use of Vigore 100 Red Tablet 4's, as it may cause painful erections or worsen the existing condition.

Contraindications

• Cardiovascular Disease
• Kidney Disease
• Allergy
• Eye Disorder

Pregnancy & Lactation

Category B pregnancy. Sildenafil has not been studied in pregnant women in a sufficient and well-controlled manner. Sildenafil is not recommended for women. Sildenafil has been shown to be teratogenic and embryotoxic in animal studies.

Precautions & Warnings

• Caution is advised when using sildenafil in patients with anatomical deformation of the penis or conditions that may predispose them to priapism (e.g., sickle cell anemia, myeloma, or leukemia).
• Some individuals may experience mild, transient, dose-related impairment of color discrimination (blue/green).
• Caution is recommended in patients with hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, a recent history of stroke, heart conditions, or retinal disorders.
• Sildenafil may cause a sudden loss or decrease in hearing.

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.