Moxigen Ophthalmic Ointment 5gm Tube

Moxigen ophthalmic solution, used for bacterial eye infections, and Moxifloxacin, an oral antibiotic used for various systemic infections. Let's clarify each one individually based on the information provided:

Moxigen Ophthalmic Solution:

Indications:

• Used for bacterial conjunctivitis caused by susceptible strains of bacteria, including both Gram-positive and Gram-negative organisms, as well as Chlamydia trachomatis.
• Also used intraocularly to prevent postoperative bacterial endophthalmitis.

Pharmacology:

• Works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, essential for bacterial DNA replication.

Dosage & Administration:

• Eye Drops: One drop into the affected eye(s) three times daily for 7 days.
• Eye Ointment: Applied thinly and evenly to the affected eye(s) three times daily initially, then reduced to twice daily as directed.
• Intraocular Injection: Administered before ocular surgery in a dose determined by the physician.

Contraindications:

• Hypersensitivity to moxifloxacin or other quinolones.

Side Effects:

• Common ocular side effects include discomfort, dry eye, burning sensation.
• Nonocular side effects reported infrequently include systemic symptoms like fever, increased cough.

Pregnancy & Lactation:

• Use during pregnancy and breastfeeding should be decided based on potential risks and benefits, with caution advised due to potential harm to the fetus or infant.

Precautions & Warnings:

• May cause temporary blurring of vision; caution advised when driving or operating machinery.
• Avoid wearing contact lenses during treatment.

Storage Conditions:

• Store below 25°C, protected from light, and discard after one month of opening.

Moxifloxacin (Systemic Use):

Indications:

• Used for various systemic infections including pneumonia, sinusitis, skin infections, and typhoid fever.

Dosage & Administration:

• Dosage varies depending on the type and severity of infection, typically administered orally once daily.

Contraindications:

• Known hypersensitivity to moxifloxacin or other quinolones.
• Conditions such as prolonged QT interval, uncorrected hypokalemia, myasthenia gravis, and concurrent use of certain medications (e.g., antiarrhythmics) are contraindicated.

Side Effects:

• Common side effects include nausea, diarrhea, dizziness.
• Serious adverse effects such as tendon rupture, allergic reactions, and QT interval prolongation are rare but possible.

Interaction:

• Can interact with medications that prolong QT interval (e.g., certain antibiotics, antipsychotics), and absorption may be affected by antacids containing aluminum, magnesium, iron, or zinc.

Pregnancy & Lactation:

• Generally avoided in pregnancy and breastfeeding due to potential risks unless deemed necessary by a healthcare provider.

Precautions & Warnings:

• Regular monitoring is recommended during therapy, especially for signs of infection and adverse reactions.
• Caution in patients with underlying conditions such as diabetes, renal impairment, or history of tendon disorders.