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Coversyl Plus 4mg+1.25mg Tablet 30pcs
Coversyl Plus 4 mg+1.25 mg Tablet contains Indapamide and Perindopril
- Perindopril belongs to a class of medicines called ACE inhibitors. It works by widening the blood vessels, which makes it easier for your heart to pump blood through them
- Indapamide is a diuretic. Diuretics increase the amount of urine produced by the kidneys
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✅ Description:
Perindopril, a non-sulfhydryl ACE (Angiotensin-Converting Enzyme) inhibitor, lowers blood pressure primarily by suppressing the renin-angiotensin-aldosterone system (RAAS). After oral intake, perindopril is converted to its active metabolite, perindoprilat, which blocks ACE activity—thus reducing the formation of angiotensin II, a potent vasoconstrictor. This results in:
- Vasodilation
- Reduced aldosterone secretion
- Mild increase in serum potassium
- Elevated plasma renin activity
It may also inhibit the breakdown of bradykinin, a vasodilator peptide, which could contribute to its antihypertensive effect. - Indapamide, a sulfonamide-type thiazide-like diuretic, acts at the cortical diluting segment of the nephron, promoting sodium and chloride excretion, with modest potassium and magnesium loss. It increases urine output, helping reduce blood pressure via a diuretic and vascular effect.
Safety Advices
Alcohol
UNSAFE
Avoid consumption of alcohol as it may increase the risk of low blood pressure, dizziness, and lightheaded
Pregnancy
UNSAFE
Coversyl Plus is not recommended in early pregnancy and must not be taken when more than three months pregnant, as it may cause serious harm to the baby if used after the 3rd month of pregnancy. Consult your doctor before taking Coversyl Plus.
Breastfeeding
UNSAFE
Coversyl Plus is not recommended for use in breastfeeding women. Your doctor may prescribe an alternative medicine, especially if you want to breast-feed when your baby is newborn or born prematurely. Consult your doctor for advice before taking Coversyl Plus.
UNSAFE
Do not drive or operate any machines if you feel dizzy or weak due to low blood pressure after taking Coversyl Plus. Consult your doctor before taking Coversyl Plus.
CONSULT YOUR DOCTOR
Coversyl Plus is not recommended for use in patients with kidney artery stenosis (narrowing of blood vessels to one or both kidneys). Coversyl Plus should be used with caution with patients having other kidney problems or under dialysis. Consult your doctor before taking Coversyl Plus.
CONSULT YOUR DOCTOR
Coversyl Plus should be used with caution in patients having liver problems. Consult your doctor before taking Coversyl Plus.
✔️ Side Effects of Coversyl Plus
- Common side effects include:
- Gastrointestinal: Nausea, vomiting, diarrhea, constipation, dyspepsia, dry mouth
- Neurological: Headache, dizziness, sleep disturbances, fatigue
- Cardiovascular: Hypotension, persistent dry cough
- Allergic: Rash, angioedema (rare but serious)
✔️ Overdose
Symptoms may include:
- Severe hypotension, dizziness, mental confusion
- Nausea, vomiting, and muscle cramps
- Oliguria or anuria, electrolyte disturbances (e.g., hyponatremia, hypokalemia)
- Management includes:
- Gastric lavage or activated charcoal
- Monitoring and correction of fluid and electrolyte imbalance
✔️ Directions For Use: Coversyl Plus
- Always take this medicine exactly as your doctor has told you
- The usual dose is one tablet once a day
- The dosage regimen if you suffer from renal impairment
- Take your tablet preferably in the morning and before a meal
- Swallow the tablet with a glass of water
✔️ Dosage & Administration of Coversyl Plus
The recommended dose is 1 to 2 tablets once daily, preferably taken in the morning before a meal.
In patients with renal impairment, start at a lower dose with close monitoring.
✔️ Drug Interactions
Enhanced hypotension may occur with the concurrent use of antihypertensives or antipsychotics.
NSAIDs (e.g., ibuprofen, diclofenac) may diminish the antihypertensive effect.
ARBs and potassium-sparing diuretics may increase the risk of hyperkalemia.
✔️ Do not use this combination in:
Patients with known hypersensitivity to Perindopril, Indapamide, other ACE inhibitors, or sulfonamide derivatives.
✔️ Use in Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal toxicity.
Breastfeeding mothers should avoid using this medication.
✔️ Use with caution in patients with:
- Renal impairment or renal artery stenosis
- Heart failure, liver cirrhosis, or diabetes
- Gout, elderly individuals, or those with atherosclerosis
- History of idiopathic or hereditary angioedema
✔️ Storage Conditions
Store below 30°C, protected from light and moisture.
Keep out of the reach of children.
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