Dermex 0.05% Cream

Indications of Dermex Cream

Clobetasol Propionate is used to treat the following dermatoses in adults, the elderly, and children over the age of one year.

• Psoriasis is a skin condition that affects people of all ages (excluding widespread plaque psoriasis)
• Dermatoses that refuse to go away
• Lichen planus is a kind of lichen that grows on the
• Discoid lupus erythematosus is a kind of lupus erythematosus.
• Other skin problems that don't react well to less powerful steroids

Pharmacology of Dermex  Cream

Clobetasol Propionate is a topical corticosteroid with a high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic responses by exhibiting anti-inflammatory effects through several pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.

Dosage of Dermex Cream

Adults, elderly, and children over 1 year: Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily and rub in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control exacerbations. In more resistant lesions, especially where there is hyperkeratosis, the effect of Clobetasol can be enhanced, if necessary, by occluding the treatment area with polythene film. Overnight occlusion only is usually adequate to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks. The maximum weekly dose should not be exceeded 50 gm/week. In the case of children, courses should be limited if possible to five days and reviewed weekly.

Administration of Dermex Cream

Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified, or scaly lesions.

Interaction of Dermex 10 Cream

Corticosteroid metabolism has been found to be inhibited by co-administered medications that inhibit CYP3A4 (e.g., ritonavir, itraconazole), resulting in increased systemic exposure.

Contraindications

It is not recommended for patients who have a hypersensitivity to any of the preparation's ingredients. Rosacea, acne vulgaris, perioral dermatitis, perianal and vaginal pruritus, pruritus without inflammation, and untreated skin diseases are all contraindications.

Side Effects of Dermex Cream

Burning and stinging sensations are the most commonly reported adverse effects. Itching, skin atrophy, cracking, and fissuring of the skin are less common side effects. Long-term usage of topical Clobetasol Propionate formulations has been linked to Cushing syndrome in both children and adults.

Pregnancy & Lactation

The use of Clobetasol Propionate cream in pregnant women has had mixed results. Corticosteroids used topically in pregnant animals can induce fetal development problems. The applicability of this discovery to people has yet to be determined. Clobetasol Propionate Cream administration during pregnancy and breastfeeding, on the other hand, should only be undertaken if the predicted benefit to the mother surpasses the potential hazards of therapy.

This medication is not known to be excreted in human milk. When Clobetasol Propionate Cream is given to a breastfeeding mother, care should be used because many medications are excreted in human milk.

Precautions & Warnings

When using occlusive dressings, the skin should be cleaned before applying a new dressing. In psoriasis, topical corticosteroids should be administered with caution since they can cause rebound relapses and local or systemic toxicity due to decreased skin barrier function. Treatment should be restricted to 5 days if applied on the face. When using Clobetasol Propionate on eyelids, be careful not to get it in your eyes, as this might cause cataracts and glaucoma.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Do not allow yourself to get frozen. Keep out of children's reach.