Adisterol 300000UI/ml Injection

This medication may be taken with or without food and can be administered orally or by intramuscular injection, depending on the prescribed treatment plan.
For nutritional supplementation, adults generally require 200–400 IU (5–10 mcg) of vitamin D3 daily. Adults over 50 years of age may need 800–1,000 IU daily, often alongside calcium supplements, for the prevention or treatment of osteoporosis. In hypoparathyroidism, much higher doses ranging from 50,000 to 200,000 IU per day may be prescribed under medical supervision.
Infants up to 12 months typically require 400 IU daily, while children and adolescents aged 1–18 years generally need 600 IU daily. Higher therapeutic doses may be used in vitamin D–resistant rickets and familial hypophosphatemia as directed by a healthcare professional.
Adisterol should not be used in patients with hypercalcemia, vitamin D toxicity, or known hypersensitivity to cholecalciferol or any component of the formulation.
Individuals with elevated calcium or phosphate levels, heart disease, or kidney disorders should use vitamin D supplements cautiously. Adequate calcium and magnesium intake is important during vitamin D therapy. The drug passes into breast milk; therefore, caution is advised during breastfeeding.
Vitamin D3 is generally well tolerated. However, excessive intake may cause hypercalcemia, leading to symptoms such as loss of appetite, headache, dry mouth, nausea, vomiting, abdominal discomfort, and constipation.
The risk of hypercalcemia may increase when vitamin D is used with thiazide diuretics, calcium, or phosphate supplements. Antiepileptic medications such as carbamazepine, phenytoin, phenobarbital, and primidone may increase vitamin D requirements. Rifampicin and isoniazid can reduce its effectiveness, while corticosteroids may oppose its action. Vitamin D may also interact with digoxin and other cardiac glycosides. Absorption can be reduced by cholestyramine, colestipol, mineral oil, orlistat, and ketoconazole.