Depo-Medrol 40mg/ml Injection Vial 2ml

Uses of Depo-Medrol 40mg/ml Injection

• Rheumatic disorders
• Skin disorders
• Eye disorders
• Nephrotic syndrome
• Systemic lupus erythematosus (SLE)

How does Depo-Medrol 40mg/ml Injection work?

Depo-Medrol 40mg/ml Injection is a steroid that works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

Side Effects of Depo-Medrol 40mg/ml Injection

• Depression
• Suicidal thoughts
• Anxiety
• Confusion
• Mood swings
• Memory loss
• Sleeping disorders
• Hallucinations (feeling, seeing, or hearing things that do not exist)
• Having strange and frightening thoughts
• Changing how you act behavioral changes
• Loneliness and isolation (having feelings of being alone)

Quick Suggestions:

• Take with food to avoid an upset stomach.
• May make it harder to fight off infections; caution against exposure to contagious diseases.
• Notify the doctor if signs of infection (fever, sore throat) occur.
• Side effects like mood changes or stomach problems may occur initially; inform the doctor if bothersome.

Indications:

• Treatment of various medical conditions such as severe allergies, asthma, rheumatic disorders, skin and eye disorders, and nephrotic syndrome.
• Provides relief by preventing the release of substances that cause inflammation.

Pharmacology

• Synthetic corticosteroids with mainly glucocorticoid activity.
• Decreases inflammation by suppressing the migration of leukocytes and reversing increased capillary permeability.

Dosage & Administration:

Administration for Local Effect:

Rheumatoid and Osteoarthritis:

• Large Size Joints (Knees, Ankles, Shoulders): 20 to 80 mg
• Medium Size Joints (Elbows, Wrists): 10 to 40 mg
• Small Size Joints (Metacarpophalangeal, Interphalangeal, Sternoclavicular, Acromioclavicular): 4 to 10 mg

Miscellaneous (Ganglion, Tendinitis, Epicondylitis):

• The dose varies (4 to 30 mg) based on the condition.
• Repeated injections may be necessary for recurrent or chronic conditions.

Dermatological Conditions:

• Inject 20 to 60 mg into the lesion.
• For large lesions, distribute doses ranging from 20 to 40 mg with repeated local injections.
• One to four injections are usually employed, with intervals varying based on the type of lesion and duration of improvement.

2. Administration for Systemic Effect:

Adrenogenital Syndrome:

• A single intramuscular injection of 40 mg every two weeks may be adequate.

Maintenance of Rheumatoid Arthritis:

• The weekly intramuscular dose varies from 40 to 120 mg.

Dermatologic Lesions Benefited by Systemic Corticoid Therapy:

• Intramuscular dose of 40 to 120 mg weekly intervals for one to four weeks.

Acute Severe Dermatitis due to Poison Ivy:

• Relief may occur within 8 to 12 hours with a single intramuscular dose of 80 to 120 mg.

Chronic Contact Dermatitis:

• Repeated injections at 5 to 10-day intervals may be necessary.

Seborrheic Dermatitis:

• A weekly dose of 80 mg may be adequate.

Asthmatic Patients:

• Relief may occur within 6 to 48 hours following intramuscular administration of 80 to 120 mg.

Allergic Rhinitis (Hay Fever):

• Relief of symptoms may occur within six hours, persisting for several days to three weeks after an intramuscular dose of 80 to 120 mg.

3. Multiple Sclerosis:

• In acute exacerbations, daily doses of 160 mg of methylprednisolone for a week followed by 64 mg every other day for 1 month be effective.

Note: Dosages are provided as general guides. Specific conditions may require adjustments, and the intervals between injections may vary based on the response to treatment. Always follow the direction of the registered physician.

How to take Depo-Medrol Injection

• Should be taken with food to prevent an upset stomach.
• Dosage and duration depend on the condition being treated.
• Follow the prescribed amount; avoid taking a larger dose or using it more often.

Interaction

• Interaction with live vaccines.
• Various interactions with other drugs affect metabolism.

Contraindications

• Hypersensitivity to the product and its constituents.
• Intramuscular corticosteroid contraindicated for idiopathic thrombocytopenic purpura.
• Contraindicated for intrathecal administration.
• Contraindicated in systemic fungal infections.

Monitoring Parameters:

• Monitor blood pressure, blood glucose, electrolytes, and growth in children.
• Caution in renal and hepatic impairment.
• Use with caution during pregnancy and lactation.

Pregnancy & Lactation

Pregnancy Category C. Since adequate human reproduction studies have not been done with corticosteroids, the use of these drugs in pregnancy, nursing mothers, or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus.

Precautions & Warnings

• Inform the doctor if you have heart failure, hypertension, diabetes, GI diseases, multiple sclerosis, myasthenia gravis, or other conditions.
• Avoid abrupt withdrawal; gradual discontinuation may be necessary.
• Regular monitoring of blood pressure, blood glucose, and electrolytes.
• Use with caution in patients with renal and hepatic impairment.
• Inform the doctor about other medications being used to avoid interactions.
• Not recommended during pregnancy and lactation.

Storage Conditions

Store in a cool and dry place away from sunlight