Clinosol Gold IV Infusion 500ml

✔️ Uses of Clinosol Gold IV Infusion

• Treatment of Nutritional deficiencies

✔️ How does Clinosol Gold IV Infusion work?

The amino acids are an essential element in the diet. The catabolism of Amino acid initiates in muscle and yields NADH and FADH2 which can be utilized for ATP generation.

✔️ Side Effects of Clinosol Gold IV Infusion

• Generally well-tolerated.
• Rare nausea and vomiting.
• Flushing and sweating if infused too quickly.
• Possible transient increases in liver tests.
• Hypersensitivity reactions were reported.
• Thrombophlebitis may occur with peripheral vein use.
• Incidence reduced by concurrent 10% fat emulsion infusion.

✔️ Related lab tests

• Ferritin
• Iron Serum
• Iron Studies
• Vitamin B12

✔️ Indication of Clinosol Gold IV Infusion

• Suitable for adult and pediatric patients needing IV nutrition.
• Provides amino acids, glucose, and electrolytes.
• Meets basal amino acid requirements.

✔️ Pharmacology

As with all intravenous fluid therapies, the primary goal is to provide adequate water to offset insensible losses, urinary losses, and other fluid losses such as those from nasogastric suction, fistula drainage, and diarrhea. Administering the infusion at a rate of 45 mL/kg/day will generally meet the fluid and amino acid needs of a stable adult patient. However, in pediatric patients, especially neonates and those with low birth weight, the dosage and constant infusion rate of intravenous dextrose must be carefully selected to mitigate the increased risk of hyperglycemia or hypoglycemia.

✔️ Administration Advice:

• Administer slowly and avoid exceeding recommended rates.
• Infuse through central or peripheral veins as appropriate.
• Monitor for adverse reactions.

✔️ Pharmacology

• Promotes protein synthesis and wound healing.
• Reduces endogenous protein catabolism.
• Can be used with dextrose, electrolytes, vitamins, trace metals, and fat supplements for total parenteral nutrition (TPN).
• Suitable for central venous or peripheral vein administration.

✔️ Dosage & Administration of Clinosol Gold IV Infusion

• Adults:
  • Nitrogen requirements vary based on the patient's condition.
  • Dosage range: 0.10-0.25 g nitrogen/kg/day (11-27 ml/kg/day).
  • Infusion rate: Not exceeding 500 ml in 3 hours (1.4-2.8 ml/min).
  • Typical volume: 1000-2000 ml per 24 hours.
• Infants and Children:
  • Maximum infusion rate: 30 ml/kg body weight/day.
  • Gradual increase in infusion rate during the first week of treatment.

✔️ Interaction

Expected not to interact with other medications at the recommended dosage.

✔️ Contraindications

• Inborn errors of amino acid metabolism.
• Severe liver damage.
• Severe uremia without dialysis facilities.
• Hyperosmolar nonketotic diabetic coma.
• Known hypersensitivity to any ingredients.

✔️ Pregnancy & Lactation

• Safe administration during pregnancy was reported.
• No animal reproduction studies were conducted.

✔️ Precautions & Warnings

• Monitor phenylalanine levels in premature infants.
• Use cautiously in patients with diabetes, severe heart failure, or renal function issues.
• Exogenous insulin may be necessary for hyperglycemia.
• Do not use if the solution is turbid or contains particles.
• Discard any unused portion.

✔️ Storage:

• Store between 15°C to 25°C.
• Protect from light and avoid freezing.
• Keep out of reach of children.