Glucodip-M XR 500 Tablet

✔️ Uses of Glucodip-M XR 500 Tablet

• Type 2 diabetes mellitus

✔️ How does Glucodip-M XR 500 Tablet work?

Sitagliptin + Metformin is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate the effective use of insulin by the body, and reduce the excess sugar that your liver makes. Together, they provide better control of blood sugar.

✔️ Side Effects of Glucodip-M XR 500 Tablet

Common side effects include diarrhea, upper respiratory tract infection, and headache. Hypoglycemia, especially when combined with sulfonylurea or insulin, can occur.

✔️ Quick Suggestions:

• If you have type 2 diabetes mellitus, you may benefit from taking Glucodip-M XR 500 Tablets. These tablets are designed to help manage your blood sugar levels and contain a combination of Sitagliptin and metformin as the active ingredients.
• Take this medicine in the exact dose and duration prescribed by the doctor. Do not change the dosage or frequency of use without consulting your doctor.
• Along with taking Glucodip-M XR 500 Tablet, it is essential that you do certain lifestyle modifications like exercising for 30 minutes daily, maintaining a healthy weight, managing stress, avoiding smoking, and drinking alcohol.
• It is also advised to have a balanced diet with adequate fruits and vegetables for good control of your blood sugar levels.
• Regularly monitor your blood sugar levels as directed by your doctor and report any changes.
• Before starting Glucodip-M XR 500 Tablet, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding and about your detailed medical history.
• It is essential to take this tablet at the same time every day and not to skip doses. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
• Headache, stomach pain, diarrhea, and nausea/vomiting may occur in some individuals with the use of Glucodip-M XR 500 Tablet. Inform your doctor if these effects bother you or do not go away.
• Talk to your doctor if you have kidney or liver disease.

✔️ Indication

Glucodip-M XR 500 Tablet is used to control high blood sugar in patients having type 2 diabetes mellitus, along with a healthy diet and regular exercise.

✔️ Pharmacology

Glucodip-M XR 500 Tablet combines two antihyperglycemic medications, Metformin HCl (a biguanide) and Sitagliptin (a dipeptidyl peptidase-4 inhibitor), to enhance glycemic control in type 2 diabetes. Sitagliptin inhibits the inactivation of incretin hormones, such as GLP-1 and GIP, which rise in response to meals, while Metformin helps reduce hepatic glucose production.

✔️ Dosage & Administration of Glucodip-M XR 500 Tablet

Dosage should be individualized, not exceeding 100 mg sitagliptin and 2000 mg metformin daily. Generally, take it twice daily with meals to minimize GI side effects. The starting dose depends on the patient's current regimen.

✔️ Interaction

Use caution with cationic drugs, phenprocoumon (monitor INR), and levothyroxine (monitor blood glucose). Adjust metformin dosage if necessary when starting or stopping thyroid hormone therapy.

✔️ Contraindications

Contraindicated in renal disease, metabolic acidosis, known allergy to the tablet or sitagliptin, and during radiologic examinations with iodinated contrast materials.

✔️ Pregnancy & Lactation

Category B in pregnancy; use only if necessary. Unknown if sitagliptin is excreted in human milk.

✔️ Precautions & Warnings

Risk of lactic acidosis, especially in certain conditions. Regularly check TSH levels in patients with hypothyroidism. Monitor patients on long-term metformin therapy.

✔️ Storage Conditions

Store below 30°C, protect from light and moisture and keep out of children's reach.