Naurif 1mg/ml Injection

Naurif is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy. Naurif will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember, you should not stop taking this medicine suddenly without talking to your doctor. In case you vomit within one hour of taking a dose, then take another dose and avoid heavy meals throughout the day. The most common side effects of taking this medicine include headache, constipation, diarrhea and weakness. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them. Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine that you might be using, especially medicines to treat epilepsy, heart problems, cancer and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team.

Uses of Naurif

Nausea

Vomiting

Side effects of Naurif

Common

Sleepiness

Weakness

Headache

Constipation

Diarrhea

How to use Naurif

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naurif may be taken with or without food, but it is better to take it at a fixed time.

How Naurif works

Naurif is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

What if you forget to take Naurif?

If you miss a dose of Naurif, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

You have been prescribed Naurif for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.

Unlike some other nausea medicines, the side effects for Naurif are relatively mild.

It is fast-acting and starts working within 30 minutes.

If you vomit within one hour of taking a dose, take another dose.

Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.

Brief Description

Indication

Nausea and vomiting, Chemotherapy-induced nausea and vomiting, Post-operative nausea and vomiting

Administration

May be taken with or without food. Take up to 1 hr before chemotherapy.

Adult Dose

Chemotherapy Induced Nausea & Vomiting Oral 1 mg PO 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemotherapy IV 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy Radiation-Induced Nausea & Vomiting 2 mg PO, 1 hr before radiation treatment Postoperative Nausea & Vomiting Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia Treatment: 1 mg (undiluted) IV push over 30 seconds Elderly: Chemotherapy Induced Nausea & Vomiting Oral: 2 mg 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemo IV: 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy Radiation-Induced Nausea & Vomiting 2 mg PO, 1 hr before radiation treatment Postoperative Nausea & Vomiting Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia Treatment: 1 mg (undiluted) IV push over 30 seconds Hepatic impairment No dosage adjustment required

Child Dose

Chemotherapy Induced Nausea & Vomiting <2 years: Safey and efficacy not established 2-16 years: As adults; 0.01 mg/kg infused over 5 min or direct inj over 30 sec, 30 min before chemotherapy Oral administration: Currently FDA-approved for IV administration in children; safety and efficacy of oral administration is not established Postoperative Nausea & Vomiting Safety and efficacy not established Not approved for postoperative N/V in pediatric patients because of lack of efficacy and QT prolongation observed in clinical trials

Renal Dose

Renal impairment IV Severe (CrCl <30 mL/min): Total clearance was not affected in patients with severe renal failure who received a single 40 mcg/kg IV dose PO No dosage adjustment required

Contraindication

Hypersensitivity.

Mode of Action

Granisetron is a selective 5-HT3-receptor antagonist with little or no affinity for other serotonin receptors. It blocks serotonin in the chemoreceptor zone.

Precaution

Subacute intestinal obstruction or ileus. Moderate to severe hepatic impairment. Congenital long QT syndrome or other risk factors for QT prolongation (e.g. electrolyte abnormalities and cumulative high-dose anthracycline therapy). Pregnancy, lactation. Lactation: excretion in milk unknown; use with caution

Side Effect

>10% Headache (10-21%) 1-10% Diarrhea (1-9%),Constipation (3-18%),Asthenia (5%),Somnolence (10%),Sedation (10%),Drowsiness (10%) Frequency Not Defined Anxiety,Fatigue,Malaise,Increased LFTs

Interaction

Phenobarbital may induce metabolism of granisetron.