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Tablet, Generic Name: Prazosin 2 mg.
Indication: Benign prostatic hyperplasia (BPH), Heart failure, Hyperaldosteronism, Hypertension, Raynaud's disease, Urge incontinence, Urinary frequency and urgency, Urinary incontinence
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✅ Description:
Indication: Benign prostatic hyperplasia (BPH), Heart failure, Hyperaldosteronism, Hypertension, Raynaud's disease, Urge incontinence, Urinary frequency and urgency, Urinary incontinence
Prazosin competitively blocks postsynaptic α1-adrenoceptors of veins and arterioles causing vasodilation, reduction in BP and total peripheral resistance usually without reflex tachycardia.
Dosage: Oral-
Hypertension:- Adult: Initially, 0.5 mg bid or tid for 3-7 days, increased to 1 mg bid or tid for the next 3-7 days, and gradually increased thereafter according to patient's response. Max: 20 mg/day in divided doses.
- Elderly: Dose reduction needed.
- Adult: Initially, 0.5 mg 2-4 times daily gradually increased according to response. Maintenance: 4-20 mg/day in divided doses.
- Elderly: Dose reduction needed.
- Adult: Initially, 0.5 mg bid, increased to a maintenance dose not exceeding 2 mg bid.
- Elderly: Dose reduction needed.
SIde effects: During cataract surgery, Intraoperative Floppy Iris Syndrome (IFIS) may occur. Postural hypotension, syncope, tachycardia, palpitations, lack of energy, dizziness, drowsiness, headache, nausea, constipation, diarrhoea, vomiting, vertigo, oedema, chest pain, dyspnoea, depression, nervousness, sleep disturbances, hallucinations, paraesthesia, nasal congestion, epistaxis, dry mouth, urinary frequency and incontinence, reddened sclera, blurred vision, tinnitus, abnormal liver enzyme values, pancreatitis, arthralgia, alopecia, lichen planus, skin rashes, pruritus, and diaphoresis; impotence and priapism.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Precautions: Prostate cancer should be ruled out before starting therapy. Patients with history of micturition syncope, angina pectoris. Treatment of heart failure due to mechanical obstruction (e.g. aortic or mitral valve stenosis, pulmonary embolism and restrictive pericardial disease). During cataract surgery, Intraoperative Floppy Iris Syndrome (IFIS) may occur. Renal and hepatic impairment. Elderly. Pregnancy and lactation.
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