Cytomis 200mcg 10pcs

Indications

A drug called Cytomis 200 is used to induce medical abortions (terminating a pregnancy). Additionally, it is employed to stop excessive postpartum bleeding. The uterus contracts more as a result of this medication's action. To get the most benefit, Cytomis 200 is administered either alone or in conjunction with another medication. It should be taken with food or as directed by your doctor.

Pharmacology

Misoprostol is rapidly de-esterified to its free acid, which is responsible for its clinical activity and, unlike the parent compound, is detectable in plasma. This free acid is responsible for misoprostol's extensive absorption. When taken with food, misoprostol acid doses result in lower maximum plasma concentrations, and taking an antacid at the same time decreases the availability of misoprostol acid overall. Misoprostol has mucosal protective properties in animals as well as antisecretory properties that prevent the secretion of gastric acid. A lack of prostaglandins within the gastric mucosa may result in dwindling bicarbonate and mucus secretion and may contribute to the mucosal damage brought on by NSAIDs, which inhibit prostaglandin synthesis. Misoprostol can increase the production of bicarbonate and mucus in humans, but this has only been demonstrated at doses of 200 and higher, which are also antisecretory.

Dosage & Administration

• Benign gastric and duodenal ulcers as well as ulcers brought on by NSAIDs should be treated with 800 mg per day (in 2-4 divided doses) with breakfast or dinner and at bedtime. The course of treatment should last at least 4 weeks but could go up to 8 weeks if necessary.
• NSAID-induced gastric and duodenal ulcer prevention: 200 meg taken with an NSAID 2-4 times per day. A dose of 100 meg can be used if this dose is not tolerated. Misoprostol should be taken as directed by the doctor for the entire course of NSAID therapy.
• 25 meg should be injected into the vaginal posterior fornix to start labor. Repeat as often as required—up to 200 meg of misoprostol total—after every six hours. Monitoring of uterine contractions and fetal heart rate is recommended. You could also take 100 mg orally. A repeated dose of 100-200 meg of oral misoprostol is administered every four hours until labor is established if cervical ripening or active labor does not occur (as evidenced by a Bishop score of 7 or more). The maximum dose is six. Monitor the mother's vital signs, the fetal heart rate, and the contractions. Four hours after taking your last misoprostol dose, you can begin oxytocin. Indicators of fetal distress or tetanic uterine contractions should be reported to a doctor. The use of oral misoprostol should be monitored by a doctor.
• Immediately after delivery, take 600 mg orally to prevent postpartum bleeding.
• 600 mg orally or 1000 mg rectally for the treatment of postpartum hemorrhage

Interaction

There is no evidence of clinically significant interaction between Misoprostol and cardiac, pulmonary, CNS drugs and NSAIDs. The bioavailability of Misoprostol is decreased with high doses of antacid.

Contraindications

Misoprostol is contraindicated to anyone with a history of allergy to prostaglandins and it is also contraindicated in pregnancy.

Side Effect

Generally, Misoprostol is well tolerated. The most frequent adverse effects associated with Misoprostol therapy involve the GI tract such as diarrhea, abdominal pain, dyspepsia, flatulence, nausea, vomiting, rashes, and dizziness. The incidence of diarrhea may be minimized by administering the drug after a meal and at bedtime and by avoiding concomitant administration with a magnesium-containing or other laxative antacid.

Pregnancy & Lactation

Misoprostol's component is contraindicated in pregnant women due to its abortifacient properties. Unless the patient requires nonsteroidal anti-inflammatory drug (NSAID) therapy and is at a high risk of developing gastric or duodenal ulceration or for developing complications from gastric or duodenal ulcers associated with the use of the NSAID, it shouldn't be administered to women who are or may become pregnant. It may be prescribed to such patients if they:

• has undergone a negative serum pregnancy test within two weeks of starting treatment.
• is able to adhere to sensible contraceptive measures.
• has been informed verbally and in writing of the risks associated with misoprostol, the potential for contraception failure, and the threat to other women who might become pregnant should the medication be taken unintentionally.
• will only start it on the second or third day of the following regular period.

Although it hasn't been researched, it's possible that the active metabolite (misoprostol acid) is excreted in milk. It is not advised for use by nursing mothers due to the possibility of serious adverse reactions in nursing infants.

Precautions & Warnings

Misoprostol is contraindicated in pregnant women and should not be used in women of childbearing potential unless the patient requires NSAID therapy in the prevention and treatment of NSAID-induced gastric and duodenal ulcers. It is important to inform women of childbearing potential that they must not be pregnant when misoprostol therapy is started and that they must use an effective method of contraception while taking the medication.

If labor must be induced, the pregnancy must have reached 36 weeks' gestation with a maternal or fetal medical indication, or it must have reached 38 weeks' gestation by reliable dating, or it must have reached lung maturity as shown by an L/S >2.0 or a positive phosphatidyl glycerol test, or it must have reached 36 weeks gestation. Acute fetal distress, placenta abruption, placenta previa, or unexplained vaginal bleeding are contraindications to inducing labor. The fetus should present with its vertex.

Storage Conditions

Store in a cool and dry place, protected from light and moisture. Keep out of the reach of the children.