Primrole 1000mg Pot-30pcs Softgel Capsules

✔️ Composition

• Evening primrose oil

✔️ Medicinal uses of Primrole 1000

Skin Conditions:

• EPO is used to relieve itchiness caused by skin conditions such as eczema and dermatitis.
• Scientific evidence supports its effectiveness in treating eczema.

Women's Health:

• Used to ease breast tenderness associated with premenstrual syndrome (PMS) and manage menopausal symptoms.
• Limited scientific evidence for reducing PMS symptoms; more research is needed.

Arthritis and Joint Conditions:

• Limited evidence for its use in managing rheumatoid arthritis (RA).
• Some studies suggest potential benefits for Raynaud's phenomenon and diabetic peripheral neuropathy.

Other Uses:

• Preliminary studies suggest EPO may help alleviate hot flashes during menopause.
• Some are used for breast pain (mastalgia), but scientific evidence is limited.

✔️ Side Effects of Primrole 1000

• Upset stomach
• Nausea
• Headache
• Diarrhoea
• Tiredness

✔️ How does Primrole 1000 work?

• Evening Primrose Oil works by reducing skin inflammation and lesions.
• It may also help the skin retain moisture, elasticity, and firmness.

✔️ Benefits of Primrole 1000

Evening Primrose Oil (EPO), particularly its content of gamma-linoleic acid (GLA), linoleic acid (LA), and omega-6 fatty acids. These components are known to have several health benefits, especially with hormone regulation and skin health. Here's a summary:

Nutritional Composition:

• Evening Primrose Oil contains gamma-linoleic acid (GLA), linoleic acid (LA), and omega-6 fatty acids.
• GLA is an essential fatty acid that plays a crucial role in hormone regulation.

Role in Hormone Regulation:

• GLA, linoleic acid, and omega-6 fatty acids are involved in regulating hormones in the body.
• These components may contribute to hormonal balance, potentially offering benefits for conditions like premenstrual syndrome (PMS).

Skin Health Benefits:

• Evening Primrose Oil is highlighted for its potential benefits for skin health.
• It is suggested to reduce skin inflammation and lesions, contributing to improved skin condition.

Promoting Skin Elasticity:

• Evening Primrose Oil is associated with promoting skin elasticity, firmness, and moisture retention.
• These properties may be beneficial for individuals seeking improved skin health.

Effectiveness in Treating PMS:

• The statement suggests that Evening Primrose Oil is highly effective in treating premenstrual syndrome (PMS) symptoms.
• Specific symptoms mentioned include irritability and bloating.

✔️ Indication of Primrole 1000

Primrole 1000, containing evening primrose oil rich in Gamma-Linolenic Acid (GLA), effectively addresses various health conditions. They aid in restoring essential oils to the skin, nourishing skin cells, and providing relief in acute skin conditions. Additionally, these capsules prove beneficial for alleviating pre-menstrual syndrome symptoms, including abdominal swelling, breast discomfort, and irritability. Evening primrose oil is a natural source of GLA, vital for prostaglandin production, contributing to overall metabolic balance. The increased GLA supports immune system strengthening.

✔️ Pharmacology

Evening Primrose Oil (EPO), particularly its impact on the composition of essential fatty acids (EFAs) and α-tocopherol levels. Here's a summary of the mentioned effects:

Improvement of EFA Composition:

• Evening Primrose Oil is noted for improving the essential fatty acid (EFA) composition of plasma, erythrocytes, and platelet lipids.
• This effect is observed in both non-diabetic individuals and Type 1 diabetic patients.

Increased Total Fat and EFA Content in Mother's Milk:

• EPO increases the total fat and EFA content of mother's milk.
• This could have potential benefits for infants receiving breast milk.

Effects on Fatty Acid Composition:

• Evening Primrose Oil affects the fatty acid composition of serum lipids and adipose tissue.
• This effect is particularly noted in men with low dihomo-gamma-linolenic acid (DGLA) levels.

Maintaining Normal Cellular Structures:

• Evening Primrose Oil helps maintain normal cellular structures.
• It is described as the precursor of DGLA, which serves as the parent compound for the 1-series prostanoids.

Prostaglandin Precursors:

• EPO, by supplying gamma-linolenic acid (GLA), is involved in the prostaglandin pathway.
• GLA converts to dihomo-gamma-linolenic acid (DGLA), a precursor of the 1-series prostanoids.
• Additionally, EPO serves as a precursor of arachidonic acid, the parent compound for the 2-series prostanoids.

In Vitro Cytostatic Activity:

• Evening Primrose Oil exhibits cytostatic activity on malignant cell lines in vitro.
• It is noted to suppress cancer cell proliferation, specifically in human osteogenic sarcoma cells.

Primrole 1000 mg (EPO) Specifics:

• The product Primrole 1000 mg supplies gamma-linolenic acid (GLA), and its bioactivity is primarily attributed to its GLA content.
• By supplying GLA, it helps bypass the rate-limiting step in the metabolism of linoleic acid (LA).

✔️ Dosage & Forms of Primrole 1000

Dosage:

• Dosage instructions should be obtained from a healthcare professional.

Forms:

• EPO is available as an oil or in capsules.
• High-quality EPO should be certified organic, packaged in light-resistant containers, refrigerated, and marked with a freshness date.

✔️ Interaction

Aspirin:

• Evening Primrose Oil may interact with aspirin, a common antiplatelet medication.

Clopidogrel:

• Interaction with clopidogrel, an antiplatelet medication used to reduce the risk of heart attacks and strokes.

Dalteparin:

• Evening Primrose Oil may interact with dalteparin, an anticoagulant (blood thinner).

Diclofenac:

• Interaction with diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) often used for pain and inflammation.

Enoxaparin:

• Evening Primrose Oil may interact with enoxaparin, another anticoagulant.

Heparin:

• Interaction with heparin, an anticoagulant used to prevent blood clots.

Ibuprofen:

• Interaction with ibuprofen, a common NSAID used for pain and inflammation.

Naproxen:

• Evening Primrose Oil may interact with naproxen, another NSAID.

Warfarin:

• Interaction with warfarin, an anticoagulant used to prevent blood clots.

✔️ Contraindications

Avoid EPO if you have epilepsy, bleeding problems, a blood disorder, or are prone to seizures.

✔️ Pregnancy & Lactation

The product is considered non-teratogenic based on animal studies. Additionally, linoleic acid (LA), gamma-linolenic acid (GLA), and dihomo-gamma-linolenic acid (DGLA) are highlighted as important components of human breast milk.
No Known Restrictions:

• There are no known restrictions mentioned for the use of Primrole 1000 during pregnancy.

Non-Teratogenic:

• The product is stated to be non-teratogenic, indicating that it is not associated with causing birth defects based on animal studies.

Components in Human Breast Milk:

• LA, GLA, and DGLA are noted as important components of human breast milk.
• This suggests that Primrole 1000, containing these components, may be considered safe during lactation.

Recommendation by World Health Organization (WHO):

• According to the World Health Organization (WHO), pregnant or lactating women should get 5% of their total daily caloric intake from essential fatty acids (EFAs).

✔️ Precautions & Warnings

• Generally safe when used in recommended dosages.
• Reported side effects are rare and mild (nausea, stomach pain, headache).
• High doses may cause stomach pain and loose stools.
• Consult a doctor before using EPO during pregnancy or breastfeeding.

✔️ Storage Conditions

Store in a cool and dry place away from sunlight

✔️ Disposal of Primrole 1000 Softgels

Check with a Pharmacist or Doctor:

• Consult your pharmacist or doctor for specific instructions on how to safely dispose of Evening Primrose Oil. They can provide guidance based on local regulations and guidelines.

Community Take-Back Programs:

• Many communities have drug take-back programs where residents can safely dispose of unused medications. Check with local pharmacies, law enforcement, or environmental agencies for information on available programs.

Dispose of Household Trash:

• If no specific disposal instructions are provided, the FDA recommends mixing the medication with an undesirable substance (such as kitty litter) in a sealed plastic bag before throwing it in the household trash. This helps prevent accidental ingestion by animals or humans.

Remove Personal Information:

• Before disposing of medication packaging, remove any personal information to protect your privacy.

Do Not Flush or Pour Down Drains:

• Avoid flushing medications down the toilet or pouring them into drains, as this can contribute to water pollution.