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A-B1 100mg Tablet 10pcs
A-B1 is primarily used to treat various manifestations of thiamine deficiency, including:
- Beriberi: A disease caused by thiamine deficiency, particularly common in alcoholics.
- Wernicke's Encephalopathy: A neurological disorder resulting from thiamine deficiency.
- Neuritis: Associated with pregnancy.
- Pellagra: Although primarily caused by niacin deficiency, thiamine can also play a role.
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✅ Description:
✔️ A-B1 may also be indicated prophylactically in conditions with:
Supplementation:
- Low dietary intake of thiamine.
- Impaired gastrointestinal absorption (e.g., due to alcohol consumption).
- Increased requirements (e.g., during pregnancy or a carbohydrate-rich diet).
Note: Follow your healthcare provider’s advice for usage.
✔️ Pharmacology
- Thiamine functions as a coenzyme (thiamine pyrophosphate) in the decarboxylation of α-ketoglutaric acid, essential for energy metabolism.
- Impacts the peripheral nervous system, gastrointestinal tract, and cardiovascular system. Symptoms include fatigue, anorexia, tachycardia, irritability, and neurological issues.
- Thiamine is well absorbed from the gastrointestinal tract, with a plasma half-life of approximately 24 hours. It is not stored in significant amounts in the body; excess is excreted in urine.
✔️ Dosage & Administration
- Prophylaxis: 3 to 10 mg daily.
- Mild Chronic Deficiency: 10 to 25 mg daily.
- Severe Deficiency: 200 to 300 mg daily.
Note: Always follow your healthcare provider’s advice for dosing.
✔️ Interactions
- Drug Interactions: No hazardous drug interactions were reported. Thiamine works synergistically with other B-complex vitamins, reducing adverse effects.
✔️ Contraindications
- No absolute contraindications, but the risk of anaphylaxis may increase with repeated parenteral administration.
- Avoid intravenous administration except in comatose patients; start a second course with a lower dose.
✔️ Side Effects
- Oral Administration: Generally safe with no adverse effects.
- Parenteral Administration: Potential for anaphylactic reactions, especially with high doses (400 mg) and repeated injections. Mild soreness may occur at the injection site.
✔️ Pregnancy & Lactation
- A-B1 can be safely administered to neonates, children, pregnant and lactating women, and elderly patients.
✔️ Storage Conditions
- Keep away from light and heat in a dry location. Keep out of children's reach.
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