Atova 10mg Tablet 15pcs

Uses of Atova 10mg Tablet

• Treats high blood cholesterol levels
• Prevents the risk of heart attack, stroke, angina, or related health problems

How does Atova 10mg Tablet work?

The drug Atova 10mg Tablet lowers cholesterol. By inhibiting the activity of the enzyme HMG-CoA reductase, which produces cholesterol in the body, it successfully lowers the levels of bad cholesterol (LDL) and triglycerides. Additionally, it affects the liver and makes the body better at removing fatty specks from the blood. It thus lowers blood cholesterol levels and eliminates the hazards linked to them.

Side Effects of Atova 10mg Tablet

• Dyspepsia
• Abdominal pain
• Indigestion
• Diarrhea
• Difficulty in falling asleep
• Joint pain
• Muscle pain
• Skin rash and itching
• Difficulty in breathing
• Urinary tract infection
• Joint pain
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Nausea
• Pain in extremities
• Abnormal liver function tests

Quick Suggestions:

• In general, Atova 10mg Tablet is considered safe, but it may cause gastrointestinal symptoms such as diarrhea, gas, or stomach upset. If you experience any of these side effects, taking the medication with food can help alleviate them.
• It's important to inform your doctor if you notice fatigue, muscle weakness, or muscle pain while taking Atova 10mg Tablet. Your doctor may conduct liver function tests before starting the treatment and periodically thereafter. If you observe signs of liver problems such as stomach pain, dark urine, or yellowing of the skin or eyes, inform your doctor immediately.
• Prior to starting treatment with Atova 10mg Tablet, make sure to inform your doctor if you have kidney disease, liver disease, or diabetes. If you have diabetes, regularly monitor your blood sugar levels as this medication may cause an increase in blood sugar levels.
• It is not safe to take Atova 10mg Tablet if you are pregnant, planning a pregnancy, or breastfeeding. To help relax your body and mind, consider trying techniques such as aromatherapy, yoga, and meditation. Breathing exercises can also be beneficial in increasing oxygen intake.
• A healthy diet is essential, especially one rich in soluble fiber found in foods like beans, legumes, whole grains, flax, apples, and citrus fruits. It is recommended to replace saturated fats with unsaturated fats, which can quickly reduce total cholesterol and LDL cholesterol levels. Foods such as avocados, olive oil, fatty fish, and nuts contain heart-healthy unsaturated fats, so incorporating them into your diet regularly is beneficial.
• Following a Mediterranean-style diet that includes olive oil, fruits, vegetables, nuts, whole grains, and fish, while limiting red meat and most dairy, is advisable. Prioritize consuming more fruits and vegetables daily, as they contain antioxidants that help lower LDL cholesterol levels.
• Limit your intake of added sugar, as recommended by the American Heart Association (ADA). Women and children should not consume more than 100 calories (25 grams) of added sugar daily, while men should not exceed 150 calories (37.5 grams).

Indication of Atova 10mg Tablet

• Atorvastatin can be used as an adjunct to diet and other non-pharmaceutical measures when the response to these measures is not sufficient. It is effective in reducing elevated levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), and triglycerides in various conditions.
• Atorvastatin is used to reduce total cholesterol and LDL-C levels in patients with hypercholesterolemia who have familial heterozygous and homozygous hypercholesterolemia. It is also effective in lowering elevated cholesterol and triglyceride levels in patients with mixed dyslipidemia (Fredrickson type Ia and Ib).
• For patients with hypertriglyceridemia (Fredrickson type IV), Atorvastatin is used to treat elevated serum triglyceride levels. It is also indicated for the treatment of patients with abnormal β-lipoproteinemia (Fredrickson type III).
• In addition to lipid-lowering effects, Atorvastatin has been shown to reduce the incidence of cardiac ischemia in asymptomatic patients or those with mild to moderately symptomatic coronary artery disease who have elevated levels of LDL-C.
• For patients with hypercholesterolemia associated with or exacerbated by diabetes or kidney transplantation, Atorvastatin is used to reduce the concentration of total cholesterol and LDL-C.
• It's important to note that the use of Atorvastatin should be done under the supervision of a healthcare professional, and the dosage and duration of treatment should be determined based on the individual patient's condition.

Pharmacology

Atorvastatin is a type of medication known as a selective HMG-CoA reductase inhibitor. This means that it targets and inhibits the action of the enzyme HMG-CoA reductase. This enzyme plays a crucial role in the conversion of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) into mevalonate, which is a key precursor for the synthesis of sterols, including cholesterol, in the body.

By inhibiting HMG-CoA reductase, Atorvastatin effectively reduces the production of cholesterol in the liver. This leads to a decrease in the levels of cholesterol in the bloodstream. Additionally, Atorvastatin increases the number of LDL receptors on the surface of liver cells. LDL receptors are responsible for the uptake and breakdown (catabolism) of low-density lipoprotein (LDL) cholesterol particles in the blood.

The combined effect of inhibiting cholesterol synthesis and increasing LDL receptor activity results in a reduction of plasma cholesterol and lipoprotein levels, particularly LDL cholesterol. This mechanism of action helps to lower elevated levels of cholesterol and improve the lipid profile in patients with conditions such as hypercholesterolemia.

It's important to note that Atorvastatin is typically used as part of a comprehensive treatment plan that includes dietary modifications and lifestyle changes. The medication works synergistically with these measures to effectively manage cholesterol levels and reduce the risk of cardiovascular diseases.

Dosage & Administration of Atova 10mg Tablet

The recommended dosage of Atorvastatin varies depending on the specific condition being treated:

• For primary hypercholesterolemia and combined hyperlipidemia in adults: The usual starting dose is 10 mg once daily. If necessary, the dose can be increased at intervals of at least 4 weeks, but not exceeding a maximum dose of 80 mg once daily.
• For children aged 10 to 18 years with primary hypercholesterolemia and combined hyperlipidemia: The initial dose is 10 mg once daily, which can be increased at intervals of at least 4 weeks if needed, up to a usual maximum dose of 20 mg once daily.
• For familial hypercholesterolemia in adults: The initial dose is typically 10 mg once daily, and it can be increased to 40 mg once daily at intervals of at least 4 weeks. If further dosage adjustment is necessary, the maximum dose of 80 mg once daily may be used. In cases of heterozygous familial hypercholesterolemia, a combination of 40 mg Atorvastatin once daily with anion exchange resin may be considered.
• For children aged 10 to 18 years with familial hypercholesterolemia: The initial dose is 10 mg once daily, which can be increased at intervals of at least 4 weeks, up to the usual maximum dose of 80 mg once daily.
• For the prevention of cardiovascular events in adults: The usual starting dose is 10 mg once daily. The dosage may be adjusted based on individual response to treatment.

Take Atova 10mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Atova 10mg Tablet can be taken with or without meals.

It's important to note that the specific dosage and treatment plan should be determined by a healthcare professional based on the patient's condition, medical history, and other relevant factors.

Interaction

Atorvastatin may interact with various medications, including:

• Antibiotics: Cephalexin, tetracycline, and gentamicin.
• Antifungals: Miconazole, fluconazole, and ketoconazole.
• HIV medicines: Abacavir, Retrovir (zidovudine), and tenofovir.
• Hepatitis C medicines: Ribavirin and elbasvir.
• Anti-arthritis medication: Cyclosporine.
• Heart rate-controlling medication: Amiodarone.
• Antihypertensive drugs: Verapamil and diltiazem.

It's important to inform your doctor about all the medications you are taking, including prescription, over-the-counter, and herbal products, to avoid any potential interactions.

In addition to medication interactions, Atorvastatin may interact with grapefruit. Grapefruit and its juice can increase the concentration of Atorvastatin in the body, so it's advisable to avoid consuming grapefruit or grapefruit products while taking this medication.

Patients with certain medical conditions should be closely monitored while taking Atorvastatin. These conditions include serious liver disease (jaundice), kidney disease, lung disease, and muscle weakness (rhabdomyolysis). Close monitoring is necessary to ensure the medication is well-tolerated and to detect any potential complications.

Contraindications

Atova 10mg Tablet should not be used in the following cases:

• Allergy: It is contraindicated in patients who are allergic to any component of the drug. If an allergic reaction occurs, the medication should be discontinued, and medical attention should be sought.
• Active liver disease or unexplained continuous elevation of serum transaminases: Atorva 10 is contraindicated in patients with active liver disease or unexplained persistent elevation of liver enzyme levels. This is because the medication is metabolized in the liver, and its use in patients with liver impairment can further compromise liver function.
• History of serious adverse reactions: Atorva 10 is contraindicated in patients who have experienced serious adverse reactions to HMG-CoA reductase inhibitors in the past. HMG-CoA reductase inhibitors are a class of drugs to which Atorva 10 belongs. If a patient has had a severe reaction to other drugs in this class, it is advised not to use Atorva 10.

Pregnancy & Lactation

Atova 10mg Tablet is contraindicated during pregnancy and lactation. Women of childbearing potential should use adequate contraceptive measures during treatment with atorvastatin. If a woman becomes pregnant while taking atorvastatin, should be discontinued.

Precautions & Warnings

Atova 10mg Tablet may have the following considerations and precautions:

• Rhabdomyolysis and kidney failure: Atova 10mg Tablet can potentially cause the breakdown of skeletal muscle tissue, leading to a condition called rhabdomyolysis, which can result in kidney failure. This risk is higher in elderly patients, those with kidney disease, and individuals with poorly controlled hypothyroidism. Close monitoring is essential, and any signs of muscle pain, weakness, or dark urine should be reported to a healthcare professional immediately.
• Age restriction: Atova 10mg Tablet should not be prescribed to children under ten years of age. Safety and efficacy data in this age group are limited.
• Allergic reactions and pre-existing conditions: Prior to starting Atova 10mg Tablet, it is important to inform your doctor if you have experienced an allergic reaction to the medication in the past. Additionally, individuals with liver problems (such as jaundice or liver cirrhosis), kidney problems, severe lung disease, a history of bleeding in the brain due to a previous heart attack or stroke, hypothyroidism, fibromyalgia, or muscle disorders (including rhabdomyolysis) should consult their doctor before taking Atova 10mg Tablet.
• Pregnancy and breast-feeding: If you are pregnant, planning to become pregnant, or breastfeeding, it is important to discuss the risks and benefits of using Atorva Tablet 15's with your healthcare provider. The medication may not be recommended in these situations.
• Alcohol consumption: Excessive alcohol consumption (more than two servings per day) should be disclosed to your doctor before starting Atova 10mg Tablet, as it may increase the risk of liver problems.

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.