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Generic Name: Amlodipine 5mg + Atenolol 25mg
Manufacturer/Distributor: ACI Limited
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✅ Description:
Indications of Tenocab 25 Tablet
This is indicated in-
Utilized to treat hypertension is Tenocab 25. (high blood pressure). When one medication is ineffective, this is a combination of two medications that manage blood pressure. Lowering high blood pressure lowers the risk of future heart attacks and strokes.
Pharmacology of Tenocab 25 Tablet
This fixed-dose combination of amlodipine and atenolol. a dihydropyridine calcium antagonist that inhibits calcium influx into both cardiac muscle and vascular smooth muscle, with vascular smooth muscle being more affected than cardiac muscle. Amlodipine is a peripheral vasodilator that works directly on vascular smooth muscle to lower blood pressure and peripheral vascular resistance. Amlodipine lowers afterload by reducing coronary vasoreactivity, coronary vasoreactivity, and tone, which reduces cardiac demand.
beta-blocker with cardioselectivity A beta-blocker is atenolol. A dose-dependent cardio-selectivity exists. By lowering cardiac output, plasma renin activity, and sympathetic outflow from the central nervous system, it reduces blood pressure (CNS). A decrease in myocardial oxygen demand is another result of atenolol's adverse inotropic and chronotropic effects.
Tenocab 25 Tablet Dosage & Administration
- Adult: This therapy is started with a single dose of this preparation; however, titration of the dosage is advised based on the therapeutic response.
- When treating senior people, it is recommended to start treatment with a fixed-dose combination of 2.5 mg of amlodipine and 25 mg of atenolol from a half-tablet.
Interaction of Tenocab 25 Tablet
This drug's 20% clearance is reduced by this medicine. The possibility exists that the heart will experience cumulatively harmful inotropic effects.
Ampicillin may reduce the concentrations of atenolol in doses of 1 gram and higher.
Beta-blockers and oral antidiabetics can be related. Atenolol, in comparison, has a lower risk of these side effects.
Contraindications of Tenocab 25 Tablet
Cardiogenic shock, hypotension, congestive heart failure, and poor left ventricular function are all symptoms of hypersensitivity to either component.
Tenocab 25 Tablet Side Effects
Tenocab 25 tablets are well tolerated together.
- Sleepiness
- Headache
- Ankle swelling
- Flushing (sense of warmth in the face, ears, neck, and trunk)
- Slow heart rate
- Palpitations
- Nausea
- Edema (swelling)
- Constipation
- Tiredness
- Cold extremities
- Anxiety or despair are some of the more common side effects.
Pregnancy & Lactation
To be utilized during pregnancy, the predicted benefit must outweigh the possible risks to a developing fetus. If you're a nursing mother, you shouldn't use this combo. Breastfeeding should be interrupted if it is deemed essential.
Precautions & Warnings
- This combination should be used cautiously in patients with airway obstruction.
- Patients who suffer from renal impairment can gain from the combination. Care is indicated if your creatinine clearance is less than 30 ml/min due to a possible reduction in the excretion of unmodified Atenolol.
- Caution should be exercised when using the combo because Amlodipine's elimination half-life is prolonged in people with significant liver damage.
- Patients should be informed that coronary heart disease might develop without being recognized when it comes to medication withdrawal.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Relevant Products / প্রাসঙ্গিক পণ্য
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