Tofacent 5mg Tablet 10pcs

Uses of Tofacent 5mg Tablet

Tofacitinib is used in the treatment of rheumatoid arthritis.

How does Tofacent 5mg Tablet work?

Tofacent 5mg Tablet works by blocking the action of the enzyme, Janus kinase. This decreases inflammation and joint damage in rheumatoid arthritis.

Side Effects of Tofacent 5mg Tablet

• The most common adverse reactions include upper respiratory tract infection, nasopharyngitis, diarrhea, and headache.
• Reported in ≥5% of patients treated with Tofacitinib for ulcerative colitis: nasopharyngitis, elevated cholesterol levels, headache, upper respiratory tract infection, increased blood creatine phosphokinase, rash, diarrhea, and herpes zoster.

Quick Suggestions:

• Used alone or in combination with other medicines for the treatment of rheumatoid arthritis that did not improve with other anti-rheumatic drugs.
• It may take 3 to 6 months to feel the maximum effect of this medication.
• Regular blood tests may be conducted to monitor liver function, kidney function, blood counts, or cholesterol levels.
• Tofacitinib can make it a bit harder for people to fight off infections.
• Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
• A TB (tuberculosis) skin test and a chest X-ray may be done before starting treatment with this medication.
• Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Indications of Tofacent 5mg Tablet

Tofacitinib 

• For adult patients with moderately to severely active rheumatoid arthritis who have had an insufficient response or intolerance to methotrexate.
• Can be used alone or in combination with other nonbiologic disease-modifying antirheumatic medicines like methotrexate.
• Also indicated for adult patients with active psoriatic arthritis who have had an unsatisfactory response or sensitivity to methotrexate or other disease-modifying antirheumatic medications.
• Used to treat ulcerative colitis in adults with moderately to highly active ulcerative colitis (UC).

Pharmacology

• Tofacitinib is a Janus kinase (JAK) inhibitor that prevents the body from responding to cytokine signals.
• Suppresses the phosphorylation and activation of STATs by inhibiting JAKs.
• Blocks the JAK-STAT pathway, reducing the inflammatory response.

Dosage & Administration of Tofacent 5mg Tablet

• Rheumatoid Arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily. Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is Tofacitinib 5 mg once daily.
• Psoriatic Arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily. Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is Tofacitinib 5 mg once daily.
• Ulcerative Colitis: Tofacitinib 10 mg twice daily for at least 8 weeks; then 5 or 10 mg twice daily. Discontinue after 16 weeks of 10 mg twice daily if adequate therapeutic benefit is not achieved. Use the lowest effective dose to maintain response.

Interaction

• Inhibitors: Cytochrome P450 3A4 (CYP3A4) inhibitors of high potency (e.g., Ketoconazole) may require adjustment of Tofacitinib dosage.
• Inducers: Inducers of CYP (e.g., Rifampin) may result in a lower clinical response to Tofacitinib.

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Pregnancy & Lactation

• Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Not known whether Tofacitinib is excreted in human milk. Caution is advised during lactation.

Precautions & Warnings

• Caution during active serious infections, including localized infections.
• Increased risk of gastrointestinal perforations.
• Regular laboratory monitoring is recommended for potential changes in lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.
• Avoid live vaccines while using Tofacitinib.

Storage Conditions

Store below 30°C. Protect from light & moisture. Keep out of the reach of children.