Generic Name: Insulin Degludec 100IU/ml
Manufacturer/Distributor: Novo Nordisk
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Indications
Tresiba FlexTouch is an extra long-acting kind of insulin used to treat both adult and pediatric patients with type 1 and 2 diabetes mellitus. It aids in blood sugar regulation by maintaining a constant quantity of insulin in the body throughout the course of the day. This lessens the risk of diabetes-related complications. It is possible to use Tresiba FlexTouch alone, in combination with a fast-acting insulin type, or with additional diabetic medications.
Pharmacology
Control of the glucose digesting system is the primary action of affront, including Affront Degludec. Affront and its analogs lower blood sugar by enhancing peripheral glucose uptake, especially by skeletal muscle and fat, and by reducing hepatic glucose production. Affront also inhibits lipolysis and proteolysis while enhancing protein union. When injected into the subcutaneous tissue resulting from a subcutaneous affront degludec terminal, affront degludec shapes multihexamers. The delayed retention of affront degludec from the subcutaneous tissue to the systemic circulation and, to a lesser extent, the authoritative of affront degludec to circulating albumin, are the primary causes of the prolonged temporal activity profile of affront degludec.
Dosage & Administration
Type 1 diabetics must use Insulin Degludec once daily in addition to mealtime insulin, and they must then individually alter their dosages.
Insulin Degludec can be given alone or in any combination with bolus insulin, GLP-1 receptor agonists, or oral anti-diabetic medications to patients with type 2 diabetes mellitus. To meet mealtime insulin needs in people with type 1 diabetes mellitus, Insulin Degludec must be coupled with short- or rapid-acting insulin. Insulin Degludec enables flexibility in the timing of insulin administration when delivery at the same time of day is not practicable. Always make sure there are at least 8 hours between injections. When a patient forgets a dose, they are encouraged to take it right away and then go back to their regular once-daily dosing regimen.
Interactions
Corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, estrogens, progestins (for example, in oral contraceptives), protease inhibitors, and atypical antipsychotics have a reduced impact on hypoglycemia (e.g. olanzapine and clozapine). Pro inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates, and sulfonamide anti-microbials have a greater hypoglycaemic effect. Octreotide and lanreotide reduced affront resistance. increased risk of weight gain and peripheral edema with pioglitazone and rosiglitazone. reduced effect of sermorelin.
Contraindications
Intolerance to the active ingredient or to any of the excipients in the medication Diabetic retinopathy, hypoglycemia, and hyperglycemia.
Side Effects
Pregnancy & Lactation
There are no clinical data on diabetes degludec in pregnant women from well-controlled studies. Animal investigations have not revealed any differences between human insulin degludec and insulin degludec used in animal reproductive studies in terms of embryotoxicity or teratogenicity. Only when the advantages of using diabetes degludec during pregnancy outweigh the risks should it be used. Studies on animal reproduction are not necessarily indicative of how people will react.
Insulin degludec with breastfeeding in the case of a nursing mother has not been investigated in a regulated clinical setting. It is unknown whether human milk contains any excreted insulin.
Precautions & Warnings
Storage Conditions
Store at 2°C to 8°C in a refrigerator. Do not freeze. In the case of insulin for recent use need not be refrigerated, try to keep it in a cool place and keep it away from heat and light. The insulin in use can be kept at room temperature for a month.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only.
The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.