Fliban 100mg | 10pcs | Women Sexual Desire | ePharma
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Fliban 100mg Tablet

Generic: Flibanserin

Type: Tablet

Pack Size: 10 Pcs

Flibanserin is prescribed to treat premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), which is characterized by low sexual desire that causes noticeable distress or interpersonal difficulty and is not brought on by any of the following: problems in the relationship, co-occurring medical or psychiatric conditions, relationship issues, or side effects from medication or other drugs.


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Discount Price: ৳ 465
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Description:

Fliban 100mg Tablet is indeed a medication used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. HSDD is characterized by a persistent or recurrent lack of sexual desire that causes distress or interpersonal difficulties. Flibanserin is specifically indicated for women who have not gone through menopause and experience low sexual desire that is bothersome to them.

It's important to note that flibanserin should not be used by women who have already gone through menopause or by men. Additionally, it is crucial to understand that this medication is not intended for enhancing sexual performance or addressing sexual problems caused by medical or mental conditions, relationship issues, or substance use.

Since Fliban is a prescription medication, it is only available through a doctor's prescription. If you believe you may benefit from this medication, it's advisable to consult with a healthcare professional who can evaluate your condition and determine if flibanserin is a suitable treatment option for you. They will consider your medical history, symptoms, and any potential interactions or contraindications before prescribing the medication.

Safety Advices


Alcohol
UNSAFE

Avoid alcohol when you take Fliban 100mg Tablet


Pregnancy
CONSULT YOUR DOCTOR

During pregnancy, Fliban 100mg Tablet should be used only when clearly needed


Breastfeeding
CONSULT YOUR DOCTOR

There are no adequate studies on women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Driving
UNSAFE

Do not drive, operate machinery, or do things that require clear thinking until at least 6 hours after you take Fliban 100mg Tablet


Kidney
UNSAFE

Fliban 100mg Tablet should be used with caution in patients with kidney disease. A dose adjustment of Fliban 100mg Tablet may be needed. Please consult your doctor. The use of Fliban 100mg Tablet is not recommended in patients with severe kidney disease.


Liver
CONSULT YOUR DOCTOR

Fliban 100mg tablets should be used with caution in patients with liver disease. A dose adjustment of Fliban 100mg Tablet may be needed. Please consult your doctor. The use of Fliban 100mg Tablet is not recommended in patients with severe liver disease.

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Uses of Fliban 100mg Tablet
  • Treat Sexual Desire Disorder
How does Fliban 100mg Tablet work?

Flibanserin is in a class of medications called a serotonin receptor 1A agonist/serotonin receptor 2A antagonist. It works by changing the activity of serotonin and other natural substances in the brain.

Side Effects of Fliban 100mg Tablet
  • Blurred vision
  • confusion
  • dizziness, fainting, or lightheadedness, especially when getting up suddenly from a lying or sitting position
  • sleepiness or unusual drowsiness
  • sweating
  • unusual tiredness or weakness
  • The feeling of constant movement of self or surroundings
  • sensation of spinning
  • Bloating
  • fever
  • nausea
  • severe cramping
  • stomach or lower abdominal pain
  • vomiting
  • Chest tightness
  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness
Indication

Fliban 100mg Tablet is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. Women with HSDD have a low sexual desire which is troubling to them. Their low sexual desire is not due to:

  • a medical or mental health problem
  • problems in the relationship
  • medicine or other drug use.

Fliban 100mg Tablet is not for use for the treatment of HSDD in women who have gone through menopause, in men, or in children.
Fliban 100mg Tablet is not for use to enhance sexual performance.

Pharmacology

Flibanserin, the active ingredient in Addyi, has a complex mechanism of action that involves multiple receptor interactions in the brain. It acts as a postsynaptic serotonin-1A (5HT-1A) receptor agonist and a 5HT-2A receptor antagonist. Additionally, it has moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors.

The exact mechanism by which flibanserin treats hypoactive sexual desire disorder (HSDD) is not fully understood. However, it is believed to work by restoring the balance of certain neurotransmitters in the brain, particularly in the prefrontal cortex, which is involved in the brain's motivation and reward systems.

One proposed theory suggests that flibanserin may enhance sexual desire by increasing dopamine and norepinephrine levels while transiently reducing serotonin levels in the prefrontal cortex. Modulating these neurotransmitters, it is thought to facilitate the prefrontal cortex's control over the brain's motivation and reward structures, thereby allowing sexual desire to manifest.

Flibanserin's effects on neurotransmitters may also involve reduced glutamate transmission, although the exact details of this interaction are not fully understood.

It's important to note that our understanding of flibanserin's mechanism of action is still evolving, and further research is needed to gain a comprehensive understanding of how it specifically addresses HSDD.

Dosage & Administration of Fliban 100mg Tablet
  • The dosage of flibanserin can vary for each individual, and it is important to follow your doctor's instructions or the directions on the label. The information provided here includes average doses for this medication. If your prescribed dose differs, do not make any changes unless instructed to do so by your doctor.
  • The dosage of flibanserin depends on the strength of the medication. The frequency of doses, the time interval between doses, and the duration of treatment will depend on the specific medical condition for which you are using the medication.
  • For the oral tablet form of flibanserin, the usual dosage for the treatment of hypoactive sexual desire disorder is 100 milligrams (mg) taken once daily at bedtime. It is not recommended for use in children.
  • If you happen to miss a dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for the missed one.
  • It is important to note that flibanserin is indicated for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). This condition is characterized by low sexual desire that causes significant distress or difficulties in relationships. It should not be used if the lack of sexual desire is due to other medical or psychiatric conditions, relationship issues, or the effects of medications or substances.
Interaction

Medicines not recommended for use with flibanserin:

  • Various HIV medications (amprenavir, atazanavir, fosamprenavir, indinavir, ritonavir, saquinavir)
  • Antifungal medications (itraconazole, ketoconazole, posaconazole, voriconazole)
  • Antibiotics (clarithromycin, erythromycin)
  • Medications used for treating hepatitis C (boceprevir, telaprevir)
  • Anti-nausea medication (aprepitant, fosaprepitant)
  • Certain cardiovascular medications (diltiazem, verapamil)
  • Antidepressant medications (nefazodone)

Medicines usually not recommended for use with flibanserin but may be required in some cases with dose adjustments:

  • Various pain medications (opioids like codeine, hydrocodone, oxycodone, and tramadol)
  • Sedatives and sleep medications (benzodiazepines like alprazolam, diazepam, lorazepam)
  • Antipsychotic medications (clozapine, olanzapine, quetiapine)
  • Antihistamines (diphenhydramine, cetirizine)
  • Muscle relaxants (baclofen, methocarbamol)

Medicines that may have increased side effects but may still be used together with flibanserin:

  • Digoxin (used for heart conditions)

Additionally, it is recommended to avoid consuming grapefruit juice while taking flibanserin.

Contraindications
  • Alcohol use: It is important to avoid alcohol consumption while taking flibanserin. Flibanserin can increase the risk of low blood pressure (hypotension) and fainting (syncope), and alcohol can further enhance these effects. Combining flibanserin with alcohol may lead to dizziness, lightheadedness, and an increased risk of accidents or injuries.
  • Co-administration with moderate or strong CYP3A4 inhibitors: Flibanserin is metabolized by the CYP3A4 enzyme in the liver. Co-administration of flibanserin with medications that are moderate or strong inhibitors of CYP3A4 can increase flibanserin blood levels, leading to an increased risk of adverse effects. It is important to inform your doctor about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to ensure there are no potential interactions.
  • Hepatic impairment: Flibanserin is primarily metabolized in the liver, so it is important to exercise caution when using flibanserin in individuals with any degree of hepatic impairment. If you have liver problems, your doctor will assess the potential risks and benefits of using flibanserin and may adjust the dosage or consider alternative treatment options.
Pregnancy & Lactation

Regarding the use of flibanserin during pregnancy, there is a lack of studies on pregnant women to determine the potential risks associated with its use. Animal studies have shown that fetal toxicity occurred only when there was significant maternal toxicity, including reduced weight gain and sedation. Adverse effects on reproduction and development in animals included decreased fetal weight, structural abnormalities, and increased fetal loss at exposures higher than 15 times the recommended human dosage.

The distribution of flibanserin in human breast milk is unknown, but it has been found to be excreted in rat milk. It is unclear whether flibanserin has any effects on the breastfed infant or affects milk production. Due to the potential for serious adverse reactions, including sedation, in a breastfed infant, breastfeeding is not recommended while undergoing treatment with flibanserin.

If you are pregnant, planning to become pregnant, or breastfeeding, it is essential to discuss the potential risks and benefits of using flibanserin with your healthcare provider. They can provide you with personalized advice based on your specific situation and help you make an informed decision about the use of this medication.

Precautions & Warnings

Coadministration of flibanserin with alcohol is strongly discouraged, as it significantly increases the risk of severe hypotension (low blood pressure) and syncope (fainting). This warning is also mentioned in the contraindications and black box warnings associated with flibanserin. The combination of flibanserin and alcohol can lead to enhanced central nervous system (CNS) depression, resulting in symptoms such as somnolence (sleepiness) and sedation. It is crucial to avoid alcohol consumption while taking flibanserin to minimize these risks.

Similarly, the coadministration of moderate or strong CYP3A4 inhibitors with flibanserin can significantly increase the concentrations of flibanserin in the body. This can also lead to hypotension and syncope. Therefore, it is important to inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medications, herbal supplements (such as ginkgo and resveratrol), and nonprescription drugs (such as cimetidine) that may have weak CYP3A4 inhibitory effects. This will help your doctor assess any potential risks and make appropriate adjustments to your treatment plan.

Flibanserin can cause CNS depression, and the risk of such depression is increased when taken during waking hours, with alcohol or other CNS depressants, or with medications that increase flibanserin concentrations (such as CYP3A4 inhibitors). It is important to be cautious while taking flibanserin and avoid activities that require mental alertness, such as driving or operating machinery, especially if experiencing somnolence or sedation.

Regarding lactation, it is unknown whether flibanserin is distributed in human breast milk. However, it has been found to be excreted in rat milk. Due to the potential for serious adverse reactions, including sedation, in breastfed infants, breastfeeding is not recommended during treatment with flibanserin. It is important to discuss breastfeeding considerations with your healthcare provider before starting flibanserin.

It is crucial to carefully follow your doctor's instructions, read the medication's contraindications, warnings, and dosing information, and consult with your healthcare provider regarding any concerns or questions you may have about flibanserin and its potential interactions or effects.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Frequently Asked Questions (FAQ)

Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause

Flibanserin can take up to four weeks to see results, and up to eight or twelve weeks to see maximum results.

Syncope, central nervous system depression, dizziness, drowsiness, fatigue, nausea, sedated state, and hypotension.

This medicine should only be used by women who have low sexual desire that is troubling to them and is not caused by a medical or mental problem, problems in the relationship, or medicine or other drug use.

Fliban 100mg Tablet (flibanserin) can make you feel sleepy, tired, and less alert.

Flibanserin is administered as a once-daily 100 mg oral tablet taken at bedtime.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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