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Drops Manufacturer/Distributor: Aristopharma Limited Generic Name: Trifluridine 1% Eye Drops
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✅ Description:
Indications
Trifluridine Sterile Eye Drops are indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, type 1 and 2.
Pharmacology
Trifluridine is a fluorinated pyrimidine nucleoside analog that interferes with the DNA synthesis of herpes simplex virus types 1 and 2 and the vaccinia virus. It prevents the replication of herpes virus DNA in 3 ways:
Competitive inhibition of viral DNA polymerase,
Incorporation into and termination of the growing viral DNA chain and
Inactivation of the viral DNA polymerase.
Dosage & Administration
Children above 6 years of age & adults: Instill 1 drop every 2 hrs while awake; maximum 9 drops/day until the corneal ulcer has completely re-epithelialized.
After re-epithelialization: Instill 1 drop every 4 hrs or at least 5 drops/day for 7 days is recommended. If there are no signs of improvement after 7 days of therapy or complete re-epithelialization has not occurred after 14 days of therapy, other forms of therapy should be considered. Continuous administration of Trifluridine eye drops for periods exceeding 21 days should be avoided because of potential ocular toxicity.
Contraindications
Contraindicated in patients who develop hypersensitivity reactions or chemical intolerance to Trifluridine.
Side Effects
The signaled side effects are a burner or a burner or a feeling of myths and transient death after installation. Other side effects are superficial punctual keratopathy, epithelial keratopathy, hypersensitivity reaction, stromal edema, irritation, keratitis Sicrics, hyperemia, and increased intraocular pressure.
Pregnancy & Lactation
Pregnancy category C. Research on pregnant women is insufficient and well-controlled. Trifluridine should be used during pregnancy only if the potential benefit proves a potential risk to the fetus.
Use during breastfeeding: Due to the relatively low dose, trifluridine is unlikely to enter breast milk after the instillation of trifluridine eye drops. Unless the potential benefits outweigh the potential risks, this drug should not be prescribed to breastfeeding mothers.
Precautions & Warnings
Trifluridine should be prescribed only for patients who have a clinical diagnosis of herpetic keratitis.
Storage Conditions
Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.
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