DHEA is the most abundant steroid hormone produced by the adrenal glands. After synthesis, it circulates throughout the body and is converted within tissues into androgens, estrogens, and other active hormones. These hormones play vital roles in fat and mineral metabolism, endocrine regulation, reproductive health, and energy balance.
DHEA levels peak around the age of 25 and gradually decline with aging. Endogenous production occurs mainly in the adrenal glands, with additional synthesis in the liver, brain, and testes in men. DHEA is metabolized into androstenedione, a key precursor of both estrogen and androgen hormones.
Supplementation alters the balance between circulating androgens and estrogens. In women, DHEA supplementation tends to increase androgen levels more significantly than estrogen levels, whereas in men, estrogen levels increase to a greater extent with comparatively smaller increases in androgens. These hormonal effects are believed to contribute to many of DHEA’s therapeutic benefits.
In the central nervous system, DHEA is concentrated in limbic regions of the brain and may function as an excitatory neuroregulator by antagonizing GABA activity. Additionally, DHEA may inhibit platelet thromboxane A₂ synthesis and enhance IGF-1, cyclic GMP, and nitric oxide production, potentially contributing to improved cardiovascular health.
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DHEA (Dehydroepiandrosterone) supplementation has been shown to support fertility in women with advanced ovarian age by improving egg quality and increasing egg and embryo numbers. DHEA tablets may be used as a nutritional adjunct to help the body’s natural DHEA functions and overall hormonal balance.
DHEA is also associated with potential benefits in a wide range of health conditions, including heart disease, stress-related disorders, cancer-related immune suppression, cognitive decline (such as memory loss and Alzheimer’s disease), obesity, aging, inflammatory imbalance, hormonal disturbances, mood disorders, osteoporosis, cardiovascular disease, diabetes, depression, erectile dysfunction, adrenal insufficiency, systemic lupus erythematosus (SLE), and allergic conditions.
Dosage should be individualized based on clinical condition and medical supervision:
Adrenal insufficiency:
50 mg daily for 3 months (replacement dose)
200 mg daily may produce supraphysiological levels (pharmacological dose)
Anorexia nervosa:
100 mg daily for 6 months (pilot study)
Diminished ovarian reserve:
50–75 mg daily in divided doses during assisted reproductive treatment
Exercise-induced muscle damage:
100 mg daily for 5 days
Major depressive disorder:
30–450 mg daily for 6–8 weeks
Metabolic syndrome:
100 mg daily for 3 months
Postmenopausal women:
25 mg daily may minimize androgenic side effects
Clinical benefits generally observed at doses ≥50 mg daily
Children & adolescents:
Not recommended for individuals under 18 years of age
Calcium channel blockers may increase DHEA levels; concurrent use should be closely monitored
Glucocorticoids may suppress endogenous DHEA production
Insulin can reduce circulating DHEA-S levels
Triazolam plasma levels may increase with DHEA
DHEA inhibits CYP3A enzymes and may affect drugs metabolized through this pathway
May improve insulin sensitivity in diabetic patients
Exhibits estrogen-like effects and may aggravate hormone-sensitive cancers
May worsen liver dysfunction
History of psychiatric disorders, including bipolar disorder or mania
Hormone-sensitive malignancies (e.g., breast or prostate cancer)
DHEA should not be used during pregnancy or breastfeeding.
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.