Vitamin B1, B6, and B12 are indicated for conditions caused by a deficiency in these essential vitamins. They are used to treat the following conditions: polyneuropathy of various origins, including diabetic, alcoholic, or toxic neuropathies; neuritis; neuralgia; cervical syndrome; shoulder-arm syndrome; lumbago; sciatica; myalgia; intercostal neuralgia; herpes zoster; trigeminal neuralgia; and as supportive therapy in facial paresis.
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The vitamins are well-absorbed orally, distributed to tissues throughout the body, and appear in breast milk. Thiamine primarily exists as diphosphate within cells and is excreted in urine when present in excess. Pyridoxine and its active forms (pyridoxal phosphate and pyridoxamine phosphate) are stored in the liver and metabolized to inactive forms excreted via urine. Higher doses lead to proportionally increased urinary excretion of unchanged vitamins.
Generally well-tolerated, though rare cases of allergic reactions may occur.
Overdose symptoms are not expected at recommended doses. In the case of an overdose, treatment is symptomatic and supportive.
No drug interactions have been reported to date.
This combination is contraindicated in patients receiving levodopa therapy and those with known hypersensitivity to any of the components in the preparation.
While the tablet form is recommended, the injection form, which contains benzyl alcohol, is not advised during pregnancy or lactation.
Store in a cool, dry place (below 25°C) and away from light. Keep out of reach of children.
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