Incrit 50mg Tablet

Uses of Incrit 50mg Tablet

• Treat type 2 diabetes in adults

How does Incrit 50mg Tablet work?

Incrit 50mg Tablet works by slowing down the inactivation of gut hormones released after eating the meals. This kind of action increases the secretion of insulin and decreases glucagon release (a hormone that raises blood glucose levels), resulting in an overall increase in blood glucose control.

Side Effects of Incrit 50mg Tablet

Common side effects include headache, upper respiratory tract infection, and nasopharyngitis. Hypoglycemia may occur when sitagliptin is used in combination with sulfonylureas or insulin.

Quick Suggestions:

• Incrit 50mg Tablet should be taken at the same time every day since this helps you remember to take it.
• It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol, or if you delay or miss a meal.
• Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremors, and anxiety.
• Be careful while driving or operating machinery until you know how Incrit 50mg Tablet affects you.
• Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea, and/or vomiting.

Indication Type 2 Diabetes Overview:s:

Type 2 diabetes is a condition characterized by the body's inability to produce sufficient insulin or effectively utilize the insulin it produces. This results in elevated blood sugar levels, a condition known as hyperglycemia. Common symptoms of type 2 diabetes include increased thirst, frequent nighttime urination, slow wound healing, heightened appetite, fatigue, and blurred vision. While some individuals may experience weight gain, others may undergo weight loss, albeit less commonly.

Type 2 diabetes can lead to various complications, including neuropathy (nerve damage), nephropathy (kidney dysfunction), retinopathy (damage to the eye's retina, potentially leading to blindness), limb amputation, sexual dysfunction, and an elevated risk of heart attacks or strokes. Managing type 2 diabetes typically involves a combination of medication, lifestyle changes such as diet and exercise, and regular monitoring to maintain healthy blood sugar levels and reduce the risk of complications.

Pharmacology

Sitagliptin is a DPP-4 inhibitor that works in individuals with type 2 diabetes by delaying the inactivation of incretin hormones. It increases the concentrations of active intact hormones, which, in turn, enhances and prolongs their activity. Incretin hormones, such as GLP-1 and GIP, regulate glucose homeostasis in the body. Sitagliptin helps increase insulin production and release from pancreatic beta cells, inhibits the release of glucagon by pancreatic alpha cells, and lowers hepatic glucose synthesis in a glucose-dependent manner. It achieves this by raising and extending active incretin levels.

Dosage & Administration of

• The recommended dose of sitagliptin is 50 mg twice daily or 100 mg once daily, and it can be taken with or without food.
• Take Incrit 50mg Tablet as a whole with a sufficient amount of water, with or without food.
• You should take this medicine regularly at the same time without fail as directed by your doctor.
• You should not consume more than the prescribed medicine.
• Do not discontinue the medicine on your own.

Interaction

Sitagliptin does not significantly affect the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives. It slightly increases the mean concentration of Digoxin, but no dose adjustment is required for either drug.

Contraindications

Sitagliptin should not be used in individuals with a history of allergic reactions to sitagliptin, including anaphylaxis or angioedema.

Pregnancy & Lactation

Sitagliptin is classified as Pregnancy Category B. While animal reproduction studies have been conducted, this medication should only be used during pregnancy if absolutely necessary. Sitagliptin is excreted in rat milk but is not known to be excreted in human milk, so caution is advised when prescribing to breastfeeding women.

Precautions & Warnings

• Sitagliptin should be discontinued immediately if pancreatitis is suspected.
• Dosage adjustments are recommended for individuals with moderate or severe renal insufficiency, including those on hemodialysis or peritoneal dialysis.
• When used in combination with medications that induce hypoglycemia, dose adjustments of sulfonylureas or insulin may be necessary to minimize the risk of hypoglycemia.
• Serious hypersensitivity reactions, such as anaphylaxis, angioedema, and skin disorders like Stevens-Johnson syndrome, have been reported. If a hypersensitive reaction occurs, discontinue sitagliptin and seek alternative diabetic medications.

Important Use Restrictions:

Sitagliptin should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis as it is ineffective in these conditions. The safety and effectiveness of sitagliptin in individuals with a history of pancreatitis have not been established.

Storage Conditions

Store sitagliptin below 25°C in a dry place away from light. Keep it out of the reach of children and do not use it beyond the expiration date. Dispense only on a qualified physician's prescription.