Lantus SoloStar Prefilled Pen 100IU/ml

Uses of Lantus SoloStar Prefilled Pen 100IU/ml

• Diabetes Mellitus (Type 1 & Type 2)

How does Lantus SoloStar Prefilled Pen 100IU/ml work?

Lantus SoloStar Prefilled Pen 100IU/ml is a long-acting modified form of insulin that works similarly to human insulin. It improves blood sugar control by enhancing glucose uptake from the blood into body tissues and also by preventing the production of glucose in the liver.

Side Effects of Lantus SoloStar Prefilled Pen 100IU/ml

• Decreased blood glucose levels
• Reaction at the injection site
• Skin Rash
• Thickening or hollowing of the skin at the injection site
• Weight gain

Quick Suggestions:

• Exercise lowers insulin needs and may accelerate insulin effects, especially if near injection sites.
• Consult your doctor to adapt your insulin regimen for exercise.
• Avoid sugary foods, and opt for low-calorie cooked meals.
• When crossing time zones, discuss the insulin schedule with your doctor.
• Lantus 100IU/ml Solution: Inject daily at the same time, rotate injection sites.
• Exercise, diet, and other medicines are vital for diabetes management.
• Monitor blood sugar due to hypoglycemia risk.
• Carry high-sugar foods for hypoglycemia symptoms.
• Opened vials at room temp for 4 weeks, unopened in fridge.
• Insulin must be clear, colorless, and particle-free.
• Rotate injection sites to prevent skin issues.

Indication of Lantus SoloStar Prefilled Pen 100IU/ml

Lantus SoloStar Prefilled Pen 100IU/ml is used to treat diabetes mellitus. Diabetes mellitus is a disease where the body does not produce enough insulin to control the level of blood sugar, resulting in high blood sugar levels.

Pharmacology

Insulin Glargine is a sterile solution designed for subcutaneous injection. It's a prolonged-acting blood glucose-lowering insulin derived from recombinant human insulin analogs using DNA technology. Its role is to manage glucose metabolism over a 24-hour period.

Dosage & Administration of

Administer Lantus SoloStar Prefilled Pen 100IU/ml subcutaneously in the upper arm, thigh, or abdominal wall. Injection into the abdominal wall leads to faster absorption. Avoid intravenous (IV) administration or using insulin pumps, as IV use may cause severe hypoglycemia.

Adult Dose:

• Subcutaneous injection for Type 1 or Type 2 Diabetes Mellitus.
• Type 1 diabetes: Start with about one-third of daily insulin needs. The rest should be satisfied by short-acting insulin. Combine with short-acting or rapid-acting insulin.
• Type 2 diabetes: Start with 10 units (or 0.2 units/kg) for those not using insulin.
• Adjust dosage based on clinical response and blood glucose levels.
• When converting from other insulins, adjust the timing and doses of shorter-acting insulins and oral antidiabetic drugs.
• From once-daily NPH insulin to Lantus SoloStar Prefilled Pen 100IU/ml: Start with the same dose as NPH.
• From twice-daily NPH insulin to Lantus SoloStar Prefilled Pen 100IU/ml: Start with 80% of the total daily NPH dose being discontinued.
• Injection sites must be rotated within the same region to prevent lipodystrophy.
• Administer once daily at the same time every day.
• Dosage may be influenced by exercise, stress, illness, coadministered drugs, and meal patterns.

Child Dose:

• For children with Type 1 Diabetes Mellitus.
• <6 years: Safety and efficacy not established.

6 years: Start with about one-third of total daily insulin needs, satisfied by rapid-acting or short-acting insulin. Usual daily maintenance range for adolescents during growth spurts is <1.2 units/kg/day.

Renal Dose:

• Dose adjustments may be necessary for renal impairment.

Overdosage:

Lantus SoloStar Prefilled Pen 100IU/ml is administered by healthcare professionals and the risk of overdose is low. However, if you experience unusual symptoms of low blood sugar, contact your doctor or nurse.

In case you miss a dose:

• Missing a dose can result in high blood sugar levels, leading to symptoms like increased thirst, frequent urination, loss of appetite, drowsiness, and a fruity odor in breath.
• If you remember a missed dose, take it as soon as possible.
• If your next dose is approaching, skip the missed dose and stick to your regular dosing schedule.
• Avoid taking a double dose to make up for the missed one, as this can cause a significant drop in blood glucose levels, which could be risky.

Interaction

Inform your doctor about your medications before taking Lantus SoloStar Prefilled Pen 100IU/ml, especially:

• Other diabetes treatments (metformin, repaglinide, etc.)
• Monoamine oxidase inhibitors (used for depression) (phenelzine, selegiline)
• Beta-blockers (for high blood pressure) (metoprolol, atenolol, clonidine, guanethidine, reserpine)
• Angiotensin-converting enzyme inhibitors (for heart conditions, high blood pressure) (benazepril, captopril, disopyramide)
• Salicylates (for pain, fever) (aspirin, pentoxifylline, propoxyphene)
• Sulphonamides (for infections) (Bactrim, cotrim)
• Oral contraceptives (birth control pills)
• Thiazides (for high blood pressure, fluid retention) (chlorothiazide, diazoxide)
• Glucocorticoids (for inflammation) (cortisone)
• Thyroid hormones (for thyroid disorders)
• Growth hormone (for growth, and metabolic processes) (somatropin)
• Danazol (affects ovulation)
• Pioglitazone (for type 2 diabetes)
• Disopyramide (for heart conditions)
• Fluoxetine (for depression)
• Fibrates (to lower blood lipids)
• Diuretics (for high blood pressure, fluid retention)
• Glucagon (for severe hypoglycemia)
• Isoniazid (for tuberculosis)
• Phenothiazine derivatives, lithium salts (for psychiatric disorders), atypical antipsychotic medicines (olanzapine, clozapine)
• Sympathomimetic medicines (for asthma) (epinephrine, salbutamol, terbutaline)
• Protease inhibitors (for HIV) (darunavir, indinavir)
• Pentamidine (for parasitic infections)

Contraindications

In patients who are hypersensitive to insulin Glargine or any of its excipients, insulin Glargine is not recommended.

Pregnancy & Lactation

Category C pregnancy. During pregnancy, insulin Glargine should only be used if the potential benefit outweighs the risk to the fetus.

It is unknown whether insulin Glargine is excreted in human milk during lactation. Because many drugs, including human insulin, are excreted in human milk, Insulin Glargine should be administered with caution to a nursing woman.

Precautions & Warnings

Caution is advised if you:

• Experience recurring low blood sugar symptoms like sweating, anxiety, rapid heartbeat, headache, intense hunger, restlessness, dizziness, and irritability. Have sugar sources on hand to address this.
• Frequently have fevers and infections.
• Have liver or kidney-related conditions.
• Have thyroid disorders.
• Are switching to a different insulin brand.
• Encounter pain, itching, or swelling at injection sites. Rotate injection sites regularly.
• Plan to change your diet habits.
• Are not consuming sufficient meals alongside insulin intake, as it can lead to significant drops in blood glucose levels.
• Should carry sugar candy for emergencies.
• Are taking insulin and not eating adequately, which could lead to drastic drops in blood glucose.

Storage Conditions

• Store between 2°C to 8°C in the refrigerator
• Do not freeze it
• Keep it out of the reach of children
• Do not open the carton of vials to protect it from light
• Any unused portion should not be stored and should be appropriately discarded.