Zimax 500mg Tablet

Uses of Zimax 500mg Tablet

• Treatment of Bacterial Infections

How does Zimax 500mg Tablet work?

Zimax 500mg Tablet works by stopping the growth of bacteria. It acts by blocking the formation of proteins necessary for bacterial growth and treats the infection.

Side Effects of Zimax 500mg Tablet

• Diarrhea
• Dry Or Scaly Skin
• Abdominal Pain
• Difficulty In Swallowing
• Vomiting
• Fever
• Acid Or Sour Stomach
• Aggression Or Anger
• Excessive Air Or Gas In the Stomach
• Heartburn

Quick Suggestions:

• Zimax 500mg Tablet is an antibiotic used for the treatment of bacterial infections of the chest, nose, throat, ear, skin, soft tissue, and certain sexually transmitted infections. It should not be used.
• You should always complete the entire course of treatment with antibiotics as prescribed by your doctor. Do not miss any dose and do not take more than the prescribed dose.
• Before starting Zimax 500mg Tablet, inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding.
• Also, inform your doctor about all other medicines that you take and your complete medical history.
• Do not take any medicine on your own without confirming with your doctor during treatment with Zimax 500mg Tablet. Antacids should be taken at least 1 hour before or 2 hours after the antibiotic.
• Diarrhea, abdominal pain, nausea, and wind (flatulence) can occur as side effects of this medicine. Inform your doctor if the side effects do not resolve even after completing the antibiotic course.

Indication of Zimax 500mg Tablet

Zimax 500mg Tablet Treats-

• Mild to moderate susceptible infections caused by bacteria and other micro-organisms which include chest, throat, and nasal infections (such as bronchitis, pneumonia, tonsillitis, sore throat, and sinusitis)
• Ear infections and skin & soft tissue infections (such as an abscess/boil) in affected individuals
• Sexually transmitted diseases such as cervicitis (caused by organisms such as Chlamydia trachomatis/ Neisseria gonorrhea) in affected individuals

Pharmacology

Azithromycin is acid-stable, which means it can be given orally without the need for stomach acid protection. Its absorption is enhanced when taken on an empty stomach.

Azithromycin is easily absorbed, and in adults, the time to reach peak concentration after oral administration ranges from 2.1 to 3.2 hours.

Azithromycin has a high concentration in phagocytes, and during active phagocytosis, large amounts of the drug are released. Consequently, the drug's concentrations in tissues can be more than 50 times higher than in plasma due to ion trapping and high lipid solubility.

Azithromycin has a long half-life, allowing for a large single dose to be administered while maintaining effective bacteriostatic levels in infected tissues for several days.

Azithromycin is primarily eliminated through biliary excretion, with approximately 6% of the given dosage appearing unchanged in urine over a week.

Following a single 500 mg dose of azithromycin, its plasma concentrations decrease in a polyphasic fashion, with an apparent plasma clearance of 630 mL/min and a terminal elimination half-life of 68 hours. The extended terminal half-life is attributed to substantial drug absorption and subsequent release from tissues.

The unique pharmacokinetic properties of azithromycin, such as its prolonged tissue presence and high concentration in infected areas, contribute to its effectiveness as an antibiotic and allow for convenient dosing regimens in certain infections.

Dosage & Administration of Zimax 500mg Tablet

The dosing instructions for Zimax 500mg Tablet are as follows:

Adult Dose:

For various bacterial infections:

• Option 1: 500 mg once daily orally for 3 days
• Option 2: 500 mg once on day 1, followed by 250 mg once daily for the next 4 days (total 5 days)

For sexually transmitted diseases caused by Chlamydia trachomatis in adults:

• Option 1: 1 gram (1000 mg) given as a single dose
• Option 2: 500 mg once on day 1, followed by 250 mg once daily for the next 2 days (total 3 days)

Children Dose:

The dose for children is based on their body weight:

For children over 6 months old:

• 10 mg/kg body weight once daily for 3 days

For children with body weight between 15-25 kg:

• 200 mg (1 teaspoonful) once daily for 3 days

For children with body weight between 26-35 kg:

• 300 mg (1½ teaspoonfuls) once daily for 3 days

For children with body weight between 36-45 kg:

• 400 mg (2 teaspoonfuls) once daily for 3 days

For the treatment of typhoid fever in both adults and children:

• 500 mg (2½ teaspoonfuls) once daily for 7-10 days.

Important instructions:

• Take Zimax 500mg Tablet as advised by your physician.
• Swallow the medicine with a glass of water. Do not crush or chew the medicine.
• The correct dose and duration of treatment will be determined by your doctor based on your age, body weight, and the specific disease condition.

Always follow your doctor's recommendations and finish the prescribed course of medication even if you start feeling better, as this helps ensure complete eradication of the infection and reduces the risk of antibiotic resistance.

Interaction

When taking multiple medications or combining them with certain foods or beverages, there is a risk of drug interactions. Here are some important points regarding the interactions of the Zimax 500mg Tablet:

Interaction with Alcohol: The interaction with alcohol is not well known. It is advisable to consult your doctor before consuming alcohol while taking this medicine.

Interaction with Lab Test: Monitoring of liver function tests and CBC differential should be done when a patient is on this medicine.

Interaction with Other Medicines:

• Zimax 500mg Tablet may inhibit the CYP3A3/4 enzyme mildly.
• It may increase the levels of certain drugs, such as tacrolimus, phenytoin, ergot alkaloids, alfentanil, astemizole, terfenadine, bromocriptine, carbamazepine, cyclosporine, digoxin, disopyramide, and triazolam. Caution is advised when using these drugs together with Zimax 500mg Tablet.
• A significant risk of cardiotoxicity is associated with the use of pimozide, so it should be avoided with Zimax 500mg Tablet.
• Zimax 500mg Tablet did not affect the response to warfarin or theophylline, but caution is still advised when used together.

Interaction with Disease:

• QT Prolongation: Inform your doctor if you have an arrhythmia, any heart disease, or are taking drugs that prolong the QT interval, such as certain psychiatric and anti-arrhythmic drugs.
• Liver Disease: Inform your doctor if you have any liver disease or are taking drugs that may cause liver damage (e.g., TB drugs, HIV drugs).
• Myasthenia Gravis: Use with caution in patients with myasthenia gravis.

Taking Zimax 500mg Tablet with food: The rate and extent of gastrointestinal absorption of the medicine may decrease, so it is recommended to take it on an empty stomach.

Other Important Considerations:

• Zimax 500mg Tablet may mask or delay symptoms of incubating gonorrhea or syphilis, so appropriate culture and susceptibility tests should be performed before initiating treatment.
• Pseudomembranous colitis has been reported with the use of macrolide antibiotics, including Zimax 500mg Tablet.

It is essential to follow your doctor's advice and inform them about any other medications, medical conditions, or dietary habits you have before starting Zimax 500mg Tablet to ensure safe and effective treatment.

Contraindications

If you are allergic to azithromycin or any other antibiotic from the same class like erythromycin or any ingredient of Zimax 500mg Tablet.

Pregnancy & Lactation

Azithromycin is classified as Pregnancy Category B, which means that animal reproduction studies have not shown any evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. The use of Azithromycin during pregnancy should be considered only if the potential benefits outweigh the potential risks, and when no safer alternatives are available.

Although animal studies suggest no harm to the fetus, the response in humans may vary, and caution should be exercised. It is essential to consult with a healthcare provider before taking Azithromycin during pregnancy.

Regarding breastfeeding, Azithromycin is not known to be secreted in breast milk significantly. However, as a precautionary measure, extreme caution should be taken when administering Azithromycin to nursing mothers. A healthcare provider should be consulted before using Azithromycin while breastfeeding to assess any potential risks to the infant.

As with any medication, it is crucial to discuss the use of Azithromycin during pregnancy or breastfeeding with a healthcare provider to make an informed decision based on the individual's specific medical condition and circumstances.

Precautions & Warnings

It is important to inform your doctor about certain medical conditions and medications before taking Zimax 500mg Tablet 6's:

• Liver problems (jaundice): Inform your doctor if you have any liver issues.
• Muscle problems (myasthenia gravis): Let your doctor know if you have myasthenia gravis, a neuromuscular disorder.
• Heart rhythm disorder (arrhythmia): If you have any heart rhythm abnormalities, inform your doctor.
• Electrolyte imbalance: Notify your doctor if you have low levels of potassium or magnesium.
• Diarrhoea: In rare cases, Zimax 500mg Tablet may cause diarrhoea. If you experience watery or bloody diarrhoea, stop taking the medicine and contact your doctor. Do not use any anti-diarrheal medication without your doctor's advice.
• Pregnancy and breastfeeding: The safety of Zimax 500mg Tablet during pregnancy is not well established, so consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medicine.
• Allergy: Do not take Zimax 500mg Tablet if you are allergic to azithromycin or other macrolide antibiotics.
• Drug interactions: Inform your doctor if you are using cholesterol-lowering drugs (statins), anti-gout or anti-arthritis drugs (colchicine), or medication for treating overactive bladder (tolterodine).

Additionally, Zimax 500mg Tablet is not recommended for patients with pneumonia who are considered inappropriate for oral therapy due to moderate to severe illness or risk factors.

Storage Conditions

Store Zimax 500mg Tablet in a cool and dry place away from sunlight. Keep it out of the reach of children and pets.