Norix 1

Uses of Norix 1

The medication is primarily used for the following conditions:

• Emergency Contraception
• Long Term Contraception

How does Norix 1 work?

Levonorgestrel is a hormone that has been used in many birth control pills which works mainly by stopping the release of an egg from the ovary and prevents fertilization of an egg (the uniting of sperm with the egg) or by preventing attachment (implantation) to the uterus (womb).

Side Effects of Norix 1

• Heavy Menstrual Bleeding
• Headache
• Nervousness
• Dizziness
• Dermatitis
• Acne
• Amenorrhea
• Nausea
• Change In Appetite
• Weight Gain
• Myalgia
• Bruise
• Feeling queasy and sick
• Headache, exhaustion, and lightheadedness
• Abdominal discomfort
• The feeling of sensitivity in the breasts
• You might bleed after taking this medicine.
• If you experience any unpleasant side effects that aren't on this list, let your doctor know.

Quick Suggestions:

• Levonorgestrel is a single tablet and you only have to take 1 dose for it to work.
• Take it as soon as possible, preferably within 12 hours and not later than 72 hours (3 days) of having unprotected sex or contraceptive failure.
• Notify your doctor if you vomit within 2-3 hours of taking this medicine.
• It is not as effective as regular methods of contraception and should be used only as an emergency measure.
• Take a pregnancy test about a week after you take Levonorgestrel as there is a 5-10% chance that it may not have worked.

Indication of Norix 1

A last-ditch method of preventing conception in the event of unprotected sexual activity is emergency contraception. After an unprotected sexual encounter, this contraceptive must be used as soon as possible, ideally within 12 hours and no later than 72 hours (3 days);

• If you or your partner engage in sexual activity without using a contraceptive method; if you have missed three consecutive doses of a contraceptive pill;
• If your partner has failed to use his condom, it has cracked, slipped, or was improperly removed;
• If you believe your intrauterine device has been expelled; if your contraceptive cap or vaginal diaphragm has moved or was prematurely removed;
• If you fear that the coitus interruptus method has failed, if you have had sexual activity while using the rhythm method during the time when you should be fertile, or if you have been sexually assaulted.

Pharmacology

By suppressing gonadotropins, oral contraceptives containing levonorgestrel reduce ovulation. Levonorgestrel slows the release of gonadotropin-releasing hormones by binding to progesterone and androgen receptors in the hypothalamus (GnRH). This process suppresses the luteinizing hormone (LH) spike that naturally occurs physiologically prior to ovulation. It stops the release of viable eggs from the ovaries and follicular rupture. Levonorgestrel has been demonstrated to be more effective when administered prior to ovulation.

Dosage & Administration of Norix 1

• 0.75 mg Tablet: The first Levonorgestrel tablet needs to be taken within 72 hours of sexual activity, and the second tablet needs to be taken after 12 hours. The effectiveness of levonorgestrel begins to decline after 48 hours of unprotected intercourse, so it must be taken within 48 hours and under no circumstances after 72 hours. You can take levonorgestrel at any point during your menstrual cycle.
• One 1.5 mg tablet must be taken daily as part of the treatment. After unprotected intercourse, the Levonorgestrel tablet must be taken as soon as possible, ideally within 12 hours, but no later than 72 hours (3 days). You can take levonorgestrel at any point during your menstrual cycle.
• It is advised to use a local method of contraception (condom, spermicide, or cervical cap) after using emergency contraception until the next menstrual cycle begins. Levonorgestrel use is not incompatible with continuing to use hormonal contraception as usual. You should continue taking the regular tablets until the end of the treatment if you used this medication while using oral contraception (the contraceptive pill). If after using Levonorgestrel there is no menstrual period in the subsequent pill-free cycle, a pregnancy test should be taken to rule out pregnancy.
• Use orally. A glass of water should be consumed along with the tablet.

Interaction

When taking Levonorgestrel, it's essential to be aware of potential drug interactions and their interactions with certain diseases:

Interaction with Alcohol:

• Avoid or minimize alcohol consumption while taking this medicine.

Interaction with Lab Tests (Thyroid function tests):

• Levonorgestrel may interfere with thyroid function tests, leading to false values. Inform your doctor before undergoing a thyroid function test.

Interaction with Medicines:

• Carbamazepine, Griseofulvin, Phenytoin, Tranexamic Acid, Bosentan, and Amprenavir may reduce the efficacy of Levonorgestrel, potentially leading to unintended pregnancy. Alternate means of birth control are recommended while taking these medicines.

Interactions with Diseases:

• Levonorgestrel should not be used in patients with liver tumors, as it may worsen the symptoms.
• It is not recommended for patients with a current or past history of increased pressure around the brain (intracranial hypertension) and should be reported to the doctor if experienced.
• Patients with liver disease or impaired liver function should avoid using Levonorgestrel, especially if jaundice or associated symptoms are observed.
• Prolonged use of high doses of this medicine may cause fluid retention and edema in some patients.
• Use of Levonorgestrel may cause the blockage of blood vessels in the eyes (retinal thrombosis), leading to partial or complete loss of vision. Patients with pre-existing eye conditions should use this medicine with caution and report any abnormality in vision to the doctor.

It's crucial to discuss any existing medical conditions, ongoing medications, or allergies with your doctor before starting Levonorgestrel to ensure safe and effective use.

Contraindications

If you're allergic to levonorgestrel or any of its excipients, don't take it.

Pregnancy & Lactation

Norix 1 cannot terminate an existing pregnancy. Research shows that progestogen if used as emergency contraception and unsuccessful, does not have harmful effects on fetal development. A recommended option is lactation. Breastfeed just before taking each Levonorgestrel pill and stop nursing after each dose, as levonorgestrel is present in breast milk.

Precautions & Warnings

Levonorgestrel should be used with caution and only in extraordinary circumstances due to the following conditions:

• Sex-steroid dependent cancer
• Past ectopic pregnancy
• Malabsorption syndromes
• Functional ovarian cysts
• Active liver disease
• Recurrent cholestatic jaundice
• History of jaundice in pregnancy
• Cardiovascular or renal impairment
• Diabetes mellitus
• Asthma
• Epilepsy
• Migraine
• Conditions aggravated by fluid retention
• Depression
• Thromboembolism (high doses)
• Lactation

Emergency contraception with Levonorgestrel should not be used as a regular method of contraception or to replace normal birth control. While the menstrual period typically starts on the expected date after taking Levonorgestrel, it may start a few days earlier or later. If there is atypical bleeding on the expected menstruation date or a delay of more than 5 days, a pregnancy test should be taken to check for pregnancy.

It's important to note that emergency contraception does not protect against sexually transmitted diseases, and necessary precautions should be taken for prevention.

Levonorgestrel is not recommended if you have had an ectopic pregnancy, salpingitis, or severe digestive disease affecting medication absorption. In case of vomiting within three hours after taking the medicine, another Levonorgestrel tablet should be taken immediately.

Storage Conditions

Do not use the product after the expiration date marked on the outer container has passed. Keep the tablets in the outer container and store them in a cool, dry place below 30°C. Ensure that the medicine is kept out of the reach of children.