The active ingredients of Vitamin C and Vitamin E have been linked with reduced risks of cardiovascular diseases in humans. Concurrent Vitamin E and Vitamin C intake suggest their action may be synergistic.
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Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality
Generally well-tolerated. Diarrhea may occasionally occur during treatment with beta-carotene and the skin may assume a slightly yellow discoloration. The side effects of vitamin A are reversible. Vitamin C and vitamin E may cause diarrhea and other gastrointestinal disturbances.
Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in the conversion of folic acid to folinic acid.
Vitamin E: Plays a role in protecting red blood cells against hemolysis; has protective effects against free radicals on polyunsaturated fatty acids found in cell membranes; plays a role in preventing oxidation of vitamins A and C.
Indications:
Vitamin C:
Vitamin E:
One tablet or capsule daily or as directed by a physician.
Vitamin C Interactions: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Vitamin E Interactions: Colestyramine, colestipol, and orlistat may interfere with vitamin E absorption. High doses of vitamin E potentiate the anticoagulant action of warfarin. Large doses of vitamin E may impair the response to iron supplementation.
Patients with a known hypersensitivity to any of the ingredients.
Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Hypervitaminosis. Avoid use in early pregnancy. Patients on anticoagulant therapy should not use ascorbic acid for a prolonged period of time.
Keep away from light and children.