Nirvana 20mg Tablet

Uses of Nirvana 20mg Tablet

It is used to treat:

• Erectile dysfunction
• Signs of Benign Prostatic Hyperplasia

How does Nirvana 20mg Tablet work?

Nirvana 20mg Tablet operates by inhibiting the action of specific enzymes known as PDE5 in the body. These enzymes normally restrict blood flow to the penis. By blocking PDE5, the medication achieves the following effects:

Improved Blood Flow to the Penis: Nirvana 20mg Tablet relaxes the blood vessels that supply the penis. This relaxation promotes increased blood flow to the penis, aiding in the achievement and maintenance of a firm and prolonged erection during sexual intercourse.

Relief from Benign Prostatic Hyperplasia (BPH) Symptoms: In addition to its effects on erectile dysfunction, Nirvana 20mg Tablet also relaxes the smooth muscles surrounding the bladder and prostate gland. This relaxation improves urine flow, reducing the uncomfortable symptoms associated with BPH, such as painful or frequent urination and involuntary urine leakage.

By targeting PDE5 enzymes and promoting blood vessel relaxation, Nirvana 20mg Tablet addresses both erectile dysfunction and urinary symptoms caused by BPH, ultimately enhancing the quality of life for men with these conditions.

Side Effects of Nirvana 20mg Tablet

• Common side effects include headache, dyspepsia, back pain, myalgia, nasal pharyngitis, and nasal congestion.
• Uncommon but possible complications include changes in color vision, sudden vision loss, hearing loss, Stevens-Johnson Syndrome, exfoliative dermatitis, angina, stroke, myocardial infarction, severe hypotension, and tachycardia.

Quick Suggestions:

• Minimize alcohol and caffeinated drink consumption, as they can exacerbate BPH symptoms.
• Maintain a healthy weight through regular exercise.
• Quit smoking to support overall prostate health.
• Ensure adequate daily fluid intake (6-8 glasses of liquids).
• Choose whole, unprocessed foods over processed options.
• Include fruits, vegetables, and fiber-rich foods in your diet.
• Take Nirvana 20mg Tablet 30 minutes to 4 hours before sexual intercourse, with an hour before sexual activity being the ideal timing.
• Do not exceed one tablet per day, following the prescribed dosage from your doctor.

Erectile Dysfunction (ED):

ED is characterized by the inability to achieve and sustain a firm erection suitable for sexual intercourse. It can be linked to physical or psychological factors such as performance anxiety, depression, low self-esteem, or stress. Additionally, certain health-related factors like smoking, alcohol consumption, obesity, sedentary lifestyle, and high blood pressure contribute to ED. Symptoms encompass difficulty in attaining and maintaining an erection, along with reduced sexual desire.

Benign Prostatic Hyperplasia (BPH):

BPH, also known as prostate enlargement, results from the non-cancerous growth of prostate gland cells, causing it to swell and compress the urethra, leading to urinary issues. It is commonly associated with aging and can lead to problems with urination. Symptoms of BPH encompass urinary incontinence, frequent urination, difficulty initiating urination, incomplete emptying of the bladder, weak urinary stream, post-urination dribbling, sudden urges to urinate, and painful urination.

Pulmonary Arterial Hypertension (PAH):

PAH is a condition in which high blood pressure affects the arteries in the lungs and heart, leading to increased strain on the heart. This occurs due to narrowed or blocked lung arteries. Symptoms include chest pain, dizziness, fatigue, and swelling in the legs and ankles.

Pharmacology

• Tadalafil is a specific phosphodiesterase type 5 (PDE5) inhibitor.
• Inhibition of PDE5 increases cGMP in smooth muscle cells.
• Elevated cGMP causes smooth muscle relaxation and increased blood flow to the corpus cavernosum, resulting in penile erection.
• PDE5 is also present in smooth muscles of the prostate and bladder wall.
• Inhibiting PDE5 increases cGMP levels, leading to relaxation of smooth muscle in the prostate and bladder.
• Smooth muscle relaxation can improve blood flow to the urinary tract and widen the bladder neck, improving voiding.

Dosage & Administration of

• Erectile Dysfunction: Typically starts at 10 mg, and can be adjusted to 20 mg or 5 mg as needed. Maximum dosing frequency is once daily, and its effect lasts up to 36 hours.
• Benign Prostatic Hyperplasia: The recommended dose is 5 mg daily.
• Combined Erectile Dysfunction and Benign Prostatic Hyperplasia: 5 mg daily.

Interaction

Interactions with various medications including nitrates, alpha-adrenergic blockers, antihypertensives, alcohol, antacids, ketoconazole, ritonavir, erythromycin, itraconazole, grapefruit juice, other HIV protease inhibitors, rifampin, carbamazepine, phenytoin, and phenobarbital can occur.

Contraindications

• Contraindicated with nitrates (e.g., nitroglycerine, isosorbide) due to potential for severe hypotension.
• Tadalafil hypersensitivity reactions.

Pregnancy & Lactation

• Classified as pregnancy category B by the USFDA. Use during pregnancy only if the benefits outweigh the risks.
• No information about Tadalafil excretion in human milk; use caution when administering to nursing mothers.

Precautions & Warnings

Caution is advised in cases of angina, renal impairment, and hepatic impairment, and when taking nitrates, alpha-blockers, alcohol, CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole), or other PDE5 inhibitors.

Storage Conditions

• Store in a dry place away from light and heat.
• Keep out of children's reach.