Methox 2.5mg | 10pcs | Rheumatoid Arthritis, Psoriasis, Cancer | ePharma
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Methox 2.5mg Tablet

Generic: Methotrexate

Type: Tablet

Pack Size: 10 Pcs

Active Rheumatoid Arthritis in Adults:

  • Used for treating severe rheumatoid arthritis in adults.
  • Rheumatoid arthritis is characterized by joint inflammation and can be non-responsive to conventional painkillers.

Polyarthritic Forms:

  • Methox 2.5mg Tablet is effective for treating polyarthritic forms of rheumatoid arthritis.
  • Polyarthritic forms involve the inflammation of five or more joints.
  • These forms are severe, active, and of unknown origin (idiopathic).
  • It is also indicated for Juvenile Idiopathic Arthritis (JIA), a condition affecting young people.

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Discount Price: ৳ 51.15
MRP: ৳ 55 7% Off

⪼ Save  ৳: 3.85  in this Product


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Description:

Methox 2.5mg Tablet contains Methotrexate, classified as an Antimetabolite. It is prescribed for severe rheumatoid arthritis, including its polyarthritic forms, unresponsive to standard painkillers. Additionally, it is used for psoriasis, psoriatic arthritis, relapsed/refractory non-Hodgkin’s Lymphoma, and severe, active, juvenile idiopathic arthritis.

Methotrexate hampers the rapid reproduction of cells, acting as an anti-tumor agent. It also suppresses the immune system, alleviating symptoms of rheumatoid arthritis and psoriasis. Here are directions for use, potential side effects, and precautions:

Safety Advices


Alcohol
UNSAFE

May increase liver damage.


Pregnancy
CONSULT YOUR DOCTOR

Consult your doctor.


Breastfeeding
CONSULT YOUR DOCTOR

Consult your doctor.


Driving
CAUTION

Avoid if feeling tired/dizzy.


Kidney
CONSULT YOUR DOCTOR

Not recommended with disorders.


Liver
CONSULT YOUR DOCTOR

Not recommended with disorders.

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Uses of Methox 2.5mg Tablet

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

How does Methox 2.5mg Tablet work?
  • Methox 2.5mg Tablet stops or reduces inflammation in rheumatoid arthritis by altering the body’s defenses.
  • In psoriasis, it kills the cells in the skin, which are growing too quickly. It is these fast-growing cells, which cause the raised patches of skin in psoriasis.
Side Effects of Methox 2.5mg Tablet

Common:

  • Sore throat, mouth soreness, loss of appetite.
  • Nausea, vomiting, stomach pain.
  • Increased liver enzymes, and infections.
  • Diarrhea, fatigue, headache, dizziness.
  • Rash, hair loss, mouth ulcers.

Uncommon:

  • Fever, anemia, decreased platelets.
  • Swollen lymph nodes, vaginal ulcers.
  • Skin pigmentation, joint/muscle pain.
  • Fatty liver fits sensitivity to light.

Rare:

  • Swelling, chest pain, depression.
  • Diabetes, decreased blood pressure.
  • Gum inflammation, acne, vision disturbances.
  • Blood in urine, seizures, brain disorders.
How to Manage Side Effects:
  • Headache: Stay hydrated, rest, and avoid bright lights.
  • Dizziness: Rest, stay hydrated, and avoid driving.
  • Diarrhea: Stick to simple meals and oral rehydration.
  • Nausea/Vomiting: Stick to simple meals, and stay hydrated.
Indications:

Methox 2.5mg Tablet is indicated for the treatment of psoriasis and rheumatoid arthritis, in patients who have tried other treatments but their illness have not improved.

Pharmacology


Mechanism of Action of Methotrexate:

Folic Acid Antagonist:

  • Methotrexate acts as an antagonist to folic acid.

Inhibition of DNA Synthesis:

  • It inhibits DNA synthesis, a crucial process for cell division and growth.

Binding to Dihydrofolate Reductase:

  • Methotrexate irreversibly binds to dihydrofolate reductase.

Inhibition of Reduced Folate Formation:

  • This binding prevents the formation of reduced folates.

Inhibition of Thymidylate Synthetase:

  • Methotrexate also inhibits thymidylate synthetase.

Resulting in Synthesis Inhibition:

  • The inhibition of dihydrofolate reductase and thymidylate synthetase leads to a cascade effect.
  • This cascade results in the inhibition of purine and thymidylic acid synthesis, crucial components for DNA replication.

Irreversible Binding:

  • The binding of Methotrexate to these enzymes is irreversible.

By disrupting these essential processes, Methotrexate exerts its anti-tumor and immunosuppressive effects, making it effective in the treatment of various conditions, including cancer and autoimmune diseases like rheumatoid arthritis.

Dosage & Administration:
  • Take as advised by your physician with water.
  • Do not crush or chew; dosage depends on age, weight, and condition.
Interaction

Drug-Drug: Inform your doctor about other medications. 

Drug-Food: Avoid caffeine-containing drinks.

Contraindications
  • Allergy: Not recommended in patients with known allergy to Methotrexate.
  • Pregnancy: Not recommended for pregnant women due to the risk of birth defects.
  • Liver Disease: Not recommended in patients with existing liver disease.
  • Blood Disorder: Not recommended in patients with existing blood diseases.
  • Lungs: Use with caution in lung issues.
Pregnancy & Lactation

Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precautions & Warnings
  • Allergy
  • Health Conditions
  • Pregnancy and Breastfeeding
  • Prior Health Issues
  • Driving
  • Dosage Adherence
  • Immediate Medical Attention
Storage Conditions
  • Keep Methox 2.5mg Tablet out of the reach and sight of children
  • Store Methox 2.5mg Tablet at a temperature below 25°C
Frequently Asked Questions (FAQ)

The time taken for Methox 2.5 Tablet to show its effect is not known.

The amount of time for which Methox 2.5 remains active in the body is not clinically established.

Methox 2.5 may cause mouth sores. Stop taking Methox 2.5 and consult your doctor if you have sores in the mouth. Your doctor may recommend folate supplements to treat mouth sores.

This medication should be taken after food in a prescribed dosage.

Inhibits growth of cancerous cells Targets bone marrow cells Controls growth of skin cells

You should avoid pregnancy if your husband is taking Methox 2.5mg Tablet. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.
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Check our pricing section for Methox 2.5mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.
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