Onaseron 8 ODT Tablet

✔️ Side Effects

• Headache
• Fatigue
• Constipation

✔️ Dosage

Emeset-4 Tablet may be taken with or without food, as directed by the physician.
Swallow the tablet whole with a glass of water.
Do not crush, chew, split, or open the tablet.
The usual dosing frequency is twice daily, but the exact dose and timing should always follow medical advice.

Adult 

Oral Administration

Chemotherapy-Induced Nausea & Vomiting (CINV)

Highly emetogenic chemotherapy:
24 mg orally once, 30 minutes before starting single-day chemotherapy.

Moderately emetogenic chemotherapy:
8 mg orally 30 minutes before chemotherapy, followed by another 8 mg 8 hours later.
Continue 8 mg twice daily (every 12 hours) for 1–2 days after chemotherapy.

Radiotherapy-Induced Nausea & Vomiting

Total body irradiation:
8 mg taken 1–2 hours before each radiotherapy fraction.

Single high-dose abdominal radiotherapy:
8 mg 1–2 hours before radiation, then 8 mg every 8 hours for 1–2 days after completion.

Daily fractionated abdominal radiotherapy:
8 mg 1–2 hours before radiotherapy, followed by 8 mg every 8 hours during each treatment day.

Post-operative Nausea & Vomiting (PONV)

16 mg orally 1 hour before induction of anesthesia.

Gastroenteritis-related Nausea & Vomiting

8 mg three times daily.

Nausea & Vomiting in Pregnancy

8 mg 2–3 times daily, only if prescribed by a physician.

Parenteral Administration

Chemotherapy-Induced Nausea & Vomiting

0.15 mg/kg IV infused over 15 minutes, administered 30 minutes before chemotherapy, then repeated at 4 and 8 hours after the first dose.

Maximum total daily dose: 16 mg.

Post-operative Nausea & Vomiting

4 mg IV or IM immediately before anesthesia or after surgery.

Administer over at least 30 seconds, preferably 2–5 minutes.

Rectal Administration

Chemotherapy-Induced Nausea & Vomiting

16 mg suppository administered 1–2 hours before chemotherapy.

Special Populations

Elderly: No dosage adjustment required

Severe hepatic impairment (Child-Pugh ≥10): Maximum dose 8 mg/day

Pediatric Dosage

Oral

Moderately emetogenic chemotherapy (Children 4–11 years):

4 mg taken 30 minutes before chemotherapy

Additional doses at 4 and 8 hours after the first dose

Then 4 mg three times daily (every 8 hours) for 1–2 days after chemotherapy

Radiotherapy-Induced Nausea & Vomiting (Children >12 years):
Same dosing as adults depending on the radiotherapy regimen.

Gastroenteritis-related Nausea & Vomiting (Children >1 month):

0.15 mg/kg body weight three times daily

Post-operative Nausea & Vomiting (Children >12 years):

16 mg orally 1 hour before anesthesia

Parenteral

Chemotherapy-Induced Nausea & Vomiting (Children >6 months):

0.15 mg/kg IV over 15 minutes, 30 minutes before chemotherapy, then repeated at 4 and 8 hours

Maximum dose: 16 mg per dose

Post-operative Nausea & Vomiting (Children 1 month–12 years):

<40 kg: 0.1 mg/kg IV

≥40 kg: 4 mg IV
Administer as a single dose before anesthesia or post-operatively if required.

Renal Impairment

No dose adjustment is necessary in patients with renal dysfunction.

✔️ Benefits:

Emeset-4 Tablet is a potent antiemetic used to prevent and manage nausea and vomiting associated with:

Cancer chemotherapy

Radiotherapy

Surgical procedures

Gastroenteritis

Pregnancy (when prescribed)

✔️ Interaction

Alcohol Interaction

Avoid alcohol consumption, as it may worsen side effects such as dizziness or drowsiness.

Drug Interactions

Significant interactions may occur with drugs that prolong the QT interval or affect serotonin levels (e.g., ziprasidone, triptans). Always consult a healthcare provider.

Drug-Food Interaction

No clinically significant food interactions are known.

✔️ Pregnancy & Lactation

Pregnancy: Not recommended during the first trimester unless clearly necessary

Breastfeeding: Not advised, as the drug may pass into breast milk

✔️ Warnings & Precautions

Contraindicated in patients with hypersensitivity to ondansetron

Do not use with apomorphine due to risk of severe hypotension and loss of consciousness

Use with caution in patients with cardiac disorders, electrolyte imbalance, bowel obstruction, liver disease, diabetes, or psychiatric illness

Concomitant use with antidepressants may increase the risk of serotonin syndrome

✔️ Storage:

Store in a cool, dry place, protected from sunlight.
Temperature: 10°C–25°C (not exceeding 30°C)
Keep out of reach of children.