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Domilux 10mg Tablet 1 Strip
Domperidone is a dopamine antagonist that primarily blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and the stomach. Its prokinetic action stems from its ability to inhibit dopamine’s influence on gastrointestinal motility.
- Enhances gastric emptying
- Promotes antral and duodenal peristalsis
- Regulates pyloric contraction
- Increases esophageal peristalsis and lower esophageal sphincter pressure, reducing regurgitation
Blood-Brain Barrier: Due to minimal penetration, Domperidone rarely causes neurological side effects.
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✅ Description:
Domilux is prescribed for various gastrointestinal and neurological conditions, including:
Dyspeptic Symptoms associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis, such as:
- Epigastric fullness and abdominal distension
- Upper abdominal pain
- Belching and flatulence
- Early satiety
- Nausea and vomiting
- Heartburn, with or without gastric regurgitation
- Non-ulcer dyspepsia
- Acute Nausea & Vomiting due to functional, organic, infectious, dietary causes, or induced by radiotherapy, drug therapy, or migraine.
- Parkinson's Disease: Management of nausea and vomiting caused by dopamine agonists.
- Radiological Studies: Used to accelerate barium transit during radiological assessments.
📌 Use only under the supervision of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage:
Oral Dosage
- Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension) every 6-8 hours (Max: 80 mg/day).
- Children: 2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg every 6-8 hours.
For Dyspepsia:
- Adults: 10-20 mg every 6-8 hours.
- Children: 0.2-0.4 mg/kg every 6-8 hours.
For Acute & Sub-Acute Nausea/Vomiting:
- Adults: 20 mg every 6-8 hours.
- Children: 0.2-0.4 mg/kg every 6-8 hours (Max treatment period: 12 weeks).
Rectal Administration (Suppositories):
- Adults: 30-60 mg every 4-8 hours.
- Children (10-25 kg): Max 30 mg/day, divided into smaller doses if required.
⚠ Do not use for more than 12 weeks without medical supervision.
✔️ Administration
Administer Domperidone 15-30 minutes before meals. If necessary, a dose may be taken before bedtime.
✔️ Side Effects
- Occasional transient intestinal cramps
- Neurological: Rare extrapyramidal effects, more common in young children
- Endocrine: Increased plasma prolactin levels, potentially causing:
- Galactorrhea
- Gynecomastia
- Allergic reactions: Rash, urticaria
✔️ Drug Interactions
- Anticholinergic drugs may counteract the antidyspeptic effect.
- Antacids & antisecretory drugs lower Domperidone’s oral bioavailability.
- Metabolized via CYP3A4 enzyme: Inhibitors such as azole antifungals, macrolide antibiotics, HIV protease inhibitors, and nefazodone may increase Domperidone levels.
- Possible altered absorption of enteric-coated or sustained-release medications.
- Compatible with: Neuroleptics and dopaminergic agonists (bromocriptine, L-dopa), reducing their gastrointestinal side effects without affecting central actions.
✔️ Contraindications
- Hypersensitivity to Domperidone
- Neonates
- Conditions where gastrointestinal stimulation is dangerous, such as:
- Gastrointestinal bleeding
- Mechanical obstruction
- Perforation
- Prolactin-releasing pituitary tumors (prolactinoma)
✔️ Overdose Management
Symptoms:
- Drowsiness, disorientation, extrapyramidal reactions (especially in children).
Treatment:
- Activated charcoal
- Symptomatic monitoring
- Anticholinergic drugs (e.g., antiparkinson agents, antihistamines) for extrapyramidal effects
✔️ Pregnancy & Lactation
- Pregnancy: Animal studies show no teratogenic effects, but use in the first trimester is advised only if the benefits outweigh the risks.
- Lactation: Excreted in breast milk in low concentrations. Nursing is not recommended unless necessary.
✔️ Precautions & Warnings
Children:
- Use cautiously due to the risk of extrapyramidal side effects.
Hepatic Impairment:
- As Domperidone is metabolized in the liver, it should be used with caution in patients with liver disease.
Renal Impairment:
- Severe renal insufficiency increases drug half-life from 7.4 to 20.8 hours.
Adjust dosage frequency (once or twice daily instead of multiple doses).
✔️ Storage:
Below 30°C. Keep away from light & moisture. Store out of children's reach
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
