Deflux 10mg Tablet 15Pcs

✔️ Uses of Deflux 10 Tablet

• Treatment of Indigestion
• Treatment of Nausea
• Treatment of Vomiting

✔️ Side Effects of Deflux 10

Domperidone can cause hyperprolactinemia (1.3%). This can cause galactorrhea, breast enlargement, pain, and decreased libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash, and itching ( 0.1%). In clinical studies, 0.05% of patients had extrapyramidal reactions.

✔️ How Deflux 10 Tablet works

Deflux 10 is a prokinetic medication. It affects the cerebral area that regulates vomiting. It also works on the upper digestive system to improve stomach and intestine movement, enabling food to pass more readily through the stomach.

✔️ Quick Suggestions:

• Deflux 10 aids in the relief of sickness, regurgitation, and indigestion.
• It should be consumed before meals, according to your doctor's instructions.
• It can make you dizzy and sleepy. Do not drive or engage in any activity that demands mental focus until you have determined how it affects you.
• Also, if you vomit at a certain time of day, avoid consuming your favorite food at that time, as your liking for that food may be turned off.
• After consuming, drink water or any other beverage for at least 30 minutes. After consuming, you should rest for at least 2 hours.
• If the smell of food makes you sick (vomit), do not prepare it because it will aggravate your situation. Allow someone else to make or use frozen cooked foods.
  When taking Deflux 10, avoid drinking alcohol as it may induce extreme drowsiness.
• As an adverse effect, dry mouth is possible. Frequent mouth rinses, excellent dental health, greater water consumption, and sugarless candy may be beneficial.
• Inform your doctor if you develop runny diarrhea, a temperature, or persistent abdominal discomfort.
• Without contacting your doctor, do not take it for more than 7 days.

✔️ Indications of Deflux 10

A complex of dyspeptic symptoms, generally associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis: 

• Discomfort in the upper abdomen, belly distention, and fullness
• Early satiety, flatulence, and belching
• Acute, functional, organic, infectious, dietary, radiotherapy, pharmacotherapy, or migraine-induced nausea and vomiting.
• Mouth burn that includes or excludes gastric reflux
• Nausea and diarrhea
• Non-ulcer dyspepsia
• Dopamine receptor agonists cause nausea and vomiting in Parkinson's disease patients.
• Accelerating the transport of barium in follow-up radiology studies.

✔️ Pharmacology

Domperidone is a dopamine antagonist that mainly blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak permeability to the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating mental and neurological side effects. Domperidone restores the normal movement and tension of the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thereby preventing the reflux of stomach contents.

✔️ Dosage & Administration of Deflux 10

If necessary, take Deflux before bedtime and between 15 and 30 minutes before meals. The usual dosages for oral administration of those who use domperidone include:

• Adults: 1020 mg (12 tablets or 1020 ml suspension), once every 68 hours a day. The maximum dose of domperidone is 80 mg per day.
• Children: 24 ml suspension/10 kg body weight or 0.40.8 ml pediatric drops/10 kg body weight every 68 hours every day.

In Acute and Subacute situations (mainly acute nausea and vomiting): 

• Adults: 20 mg (2 tablets or 20 ml suspension), every 68 hours per day
• Children: 0.20.4 mg/kg (24 ml suspension) /10 kg or 0.40.8 ml pediatric drops/10 kg) body weight, once every 68 hours a day. (In acute nausea and vomiting, the maximum treatment period is 12 weeks).

Indigestion symptoms: 

• Adults: 1020 mg (12 tablets or 1020 ml suspension), once every 68 hours a day.
• Children: 0.20.4 mg/kg (24 ml suspension/10 kg or 0.40.8 ml pediatric drops/10 kg) weight every 68 hours per day.

Rectal Suppositories: 

• Adults (including the elderly): 3060 mg every 48 hours.
• Children: The maximum daily rectal dose for children weighing 10 to 25 kg is 30 mg. If necessary, it can be taken in divided doses throughout the day.
• The maximum treatment period is 12 weeks.

✔️ Interaction

Deflux can reduce the risk of bromocriptine-causing hypoprolactin. The effect of domperidone on GI function can be antagonized by antimuscarinic drugs and opioid analgesics. Caution should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.

✔️ Contraindications

Deflux is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation could be dangerous, ie gastrointestinal bleeding, mechanical obstruction, or perforation. Prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.

✔️ Pregnancy & Lactation

The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.

✔️ Precautions & Warnings

Hypersensitivity. Patients with prolactin-releasing pituitary hormone, chronic administration, or regular prevention of postoperative nausea and vomiting.

✔️ Storage Conditions

Store below 30 ° C protected from light and moisture. Keep out of the reach of children.