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Prenovax 23 | Pneumococcal Polysaccharide Vaccine 23 Valent
Polysaccharide Pneumococcal Vaccine -
- Adults and children ≥2 years: A single 0.5 mL dose administered intramuscularly or subcutaneously.
- Not recommended for children under 2 years due to limited immune response.
- Ideally administer the vaccine at least 2 weeks before elective splenectomy or starting immunosuppressive treatments such as chemotherapy.
- Delay vaccination during active chemotherapy or radiation therapy. Resume no earlier than 3 months post-treatment, though longer intervals may be required for certain patients.
- Patients with HIV (symptomatic or asymptomatic) should receive the vaccine as early as possible after diagnosis.
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✅ Description:
Each 0.5 mL dose of the vaccine contains 25 micrograms of purified capsular polysaccharides from the following 23 pneumococcal serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F.
This vaccine is recommended for the active immunization of individuals 2 years of age and older, including children, adolescents, and adults, to help protect against pneumococcal disease.
The vaccine is formulated using purified capsular polysaccharides from 23 pneumococcal serotypes that are responsible for approximately 90% of invasive pneumococcal infections. The antigens stimulate an immune response, leading to the production of antibodies that protect against pneumococcal disease.
✔️ Dosage & Administration |Revaccination:
Routine revaccination is not advised for healthy adults or children.
A second dose may be considered for high-risk individuals after at least 5 years, especially those with conditions like asplenia or nephrotic syndrome.
Revaccination within 3 years is not recommended due to a higher incidence of adverse effects.
✔️ Side Effects
Commonly reported side effects include:
Injection site reactions: pain, swelling, redness (up to 60%)
Systemic symptoms: headache (17.6%), fatigue or weakness (13.2%), and muscle pain (11.9%)
✔️ Drug Interactions
Can be given simultaneously with the influenza vaccine, but at separate injection sites using different needles.
✔️ Avoid administration in:
Individuals allergic to any vaccine component.
Those with fever, acute infections, or during the acute phase of chronic illness.
Individuals with uncontrolled epilepsy or progressive neurological disorders.
✔️ Pregnancy & Lactation
Insufficient data from animal studies on reproductive toxicity.
Use during pregnancy only if needed.
Unknown if excreted in human milk; exercise caution when administering to lactating mothers.
✔️ Precautions & Warnings
Delay vaccination in cases of significant fever or infection unless the delay poses a greater health risk.
- Never administer intravascularly or intradermally to avoid adverse reactions.
- Immunocompromised patients may have a weakened response, and the vaccine may not provide full protection in all cases.
- Anaphylaxis readiness: Epinephrine should be available during administration.
- Pneumococcal vaccination does not replace the need for prophylactic antibiotics in high-risk individuals.
- Patients at elevated risk (e.g., those without a spleen or undergoing immunosuppression) should be advised to seek early medical attention in case of fever or severe illness.
- Effectiveness in cases like basilar skull fractures or CSF leaks is uncertain.
✔️ Storage:
Store at 2°C to 8°C.
Protect from light and do not freeze.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
