Extranil 5mg Tablet 10pcs

✔️ Uses of Extranil 5mg Tablet

• To manage and relieve signs of Parkinson’s disease
• To control extrapyramidal effects caused by certain medicines

✔️ How does Extranil 5mg Tablet work?

Procyclidine hydrochloride, an antimuscarinic agent, treats parkinsonism by correcting the relative cholinergic excess resulting from dopamine deficiency. It is quickly absorbed from the GI tract and cleared from tissues, with effects apparent within 5 to 20 minutes post-intravenous administration and lasting up to 4 hours.

✔️ Side Effects of Extranil 5mg Tablet

Possible side effects include:

• Dryness of mouth
• Blurred vision
• Dizziness
• Gastrointestinal disturbances (nausea, vomiting, epigastric distress, constipation)
• Allergic reactions (e.g., rash)
• Muscular weakness
• High doses may cause vertigo, confusion, and hallucinations

Side effects can usually be minimized by adjusting the dosage and taking the medication after meals

✔️ Quick Suggestions:

• Procyclidine helps treat Parkinson's disease and drug-induced abnormal movements.
• Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
• It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
• Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.
• Do not stop taking Procyclidine without talking to your doctor first as that may cause worsening of symptoms.
• Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.

✔️ Indications:

Extranil 5 mg (Procyclidine) is used as an adjunctive treatment for various forms of Parkinsonian syndrome. This includes idiopathic Parkinson's disease (paralysis agitans), postencephalitic parkinsonism, and arteriosclerotic parkinsonism. It is also effective in managing extrapyramidal symptoms such as pseudoparkinsonism, acute dystonic reactions, and akathisia caused by neuroleptic drugs like phenothiazine derivatives.

✔️ Pharmacology

Procyclidine hydrochloride is an antimuscarinic antiparkinsonian agent with relatively low toxicity. It is a synthetic tertiary amine. The drug alleviates Parkinsonian symptoms by addressing the relative excess of cholinergic activity that arises due to dopamine deficiency. It is absorbed from the gastrointestinal tract and is rapidly cleared from the tissues. Intravenous administration results in an effect within 5 to 20 minutes, lasting up to 4 hours.

✔️ Dosage & Administration of Extranil 5mg Tablet

Oral Administration:

• Adults:
  • Parkinsonism: Start with 2.5 mg three times daily, increasing to 5 mg three times daily, with an additional 5 mg at bedtime if needed. Adjust dosage as tolerated, up to a total daily dose of 20 to 30 mg divided into 3 to 4 doses.
  • Drug-induced Extrapyramidal Symptoms: Start with 2.5 mg three times daily. Increase by 2.5 mg daily increments as needed and tolerated.

Children:

• Safety and efficacy in pediatric patients have not been established. Use only if the potential benefits outweigh the risks.

✔️ Procyclidine may interact with:

• Phenothiazines
• Anticonvulsants
• Levodopa
• Ketoconazole
• Monoamine oxidase inhibitors
• Adsorbents
• Antidiarrheals
• Alcohol
• Other anticholinergic drugs

✔️ Procyclidine is contraindicated in patients with:

• Tardive dyskinesia
• Hypersensitivity to Procyclidine

✔️ Pregnancy & Lactation

There is no adequate data on the safe use of Procyclidine during pregnancy and lactation. The potential benefits should be weighed against the possible risks to the mother and child.

✔️ Precautions & Warnings

• Use with caution in children and elderly patients.
• Be cautious when administering Procyclidine to patients with diarrhea, cardiovascular disease, glaucoma, urinary retention, and hepatic or renal impairment.

✔️ Storage Conditions:

• Store in a cool, dry place away from light.
• Keep out of reach of children.