Teripen is indicated for the treatment of osteoporosis in patients at high risk of fractures. It is used for:
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Teriparatide is a synthetic form of the first 34 amino acids of the human parathyroid hormone (PTH), which is the biologically active region. Endogenous PTH plays a crucial role in maintaining calcium and phosphate balance by regulating bone remodeling, renal calcium reabsorption, and intestinal calcium absorption. Teriparatide binds with high affinity to PTH receptors on osteoblasts and renal tubular cells.
Unlike chronic PTH exposure, which may lead to bone resorption (as seen in hyperparathyroidism), once-daily subcutaneous administration of Teriparatide promotes new bone formation by preferentially activating osteoblasts over osteoclasts. This results in increased bone mass and strength in both cortical and trabecular bone. In clinical and animal studies, Teriparatide enhanced bone microarchitecture and significantly improved skeletal integrity.
Common side effects include:
Recommended Dose (for all indications):
20 mcg administered subcutaneously once daily.
Indications include:
Postmenopausal osteoporosis.
Primary or hypogonadal osteoporosis in men.
Glucocorticoid-induced osteoporosis in both sexes.
Route:
Subcutaneous injection into the thigh or abdomen.
Patients should be advised to sit or lie down when receiving their initial doses, due to the risk of orthostatic hypotension.
Pediatric Use:
Not approved for use in children or adolescents, as safety and efficacy have not been established.
Hepatic Impairment:
No specific studies available—use with caution.
Note: Always inspect the solution before use. It should appear clear and colorless. Do not use if discolored or containing particles.
Known hypersensitivity to teriparatide or any formulation component (e.g., past reactions like angioedema or anaphylaxis).
Patients with:
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