Oleanz 10mg 10pcs - ePharma
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Oleanz 10mg 10pcs

Generic: Olanzapine

Type: Tablet

Pack Size: 10 Pcs

Tablet. Generic Name: Olanzapine INN 5mg & 10mg/tablet Manufacturer/Distributor: Sun Pharma


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Discount Price: ৳ 43.32
MRP: ৳ 45.6 5% Off

⪼ Save  ৳: 2.28  in this Product


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✅ Description:

Indications

Olanzapine is used to treat schizophrenia and similar psychoses in which positive symptoms (such as delusions, hallucinations, disordered thinking, anger, and suspiciousness) and/or negative symptoms (such as flattened affect, emotional and social withdrawal, and speech poverty) are present. Olanzapine is used to treat bipolar disorder's acute manic or mixed episodes, with or without psychotic symptoms and with or without a rapid cycling course.

 

 

Pharmacology

Olanzapine is an antipsychotic drug that binds to serotonin 5HT2A/2C, 5HT3, and 5HT6 receptors, as well as dopamine D1, D2, D3, D4, D5, cholinergic muscarinic receptors M1-M5, 1 adrenergic receptors, and histamine H1 receptors. 

Olanzapine's mechanism of action, like those of other anti-schizophrenia medicines, remains unclear. 

However, it has been suggested that the drug's effectiveness in schizophrenia is mediated through antagonism of dopamine and serotonin type 2 (5HT2). 

After oral treatment, olanzapine is rapidly absorbed, reaching peak plasma concentrations in 5 to 8 hours. 

Food has no effect on the absorption. 

Olanzapine is not carcinogenic, nor is it mutagenic or clastogenic.

Dosage & Administration

Schizophrenia, combination therapy for Mania, Bipolar Disorder: The initial dose is 5-10 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 10 mg daily only after reassessment. Maximum dose is 20 mg daily.

Monotherapy for Mania: Initially 15 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 15 mg only after reassessment. Maximum dose is 20 mg daily.

Olanzapine can be given without regard to meals. Gradual tapering of the dose should be considered while discontinuing Olanzapine.

 

Interactions

Olanzapine may counteract the effects of dopamine agonists and levodopa. 

 

Omeprazole and Rifampicin, for example, may enhance Olanzapine elimination by inducing CYP1A2 or glucoronyl transferase enzymes. 

 

Olanzapine clearance might be hampered by CYP1A2 inhibitors. 

 

Carbamazepine may improve Olanzapine clearance. 

 

The oral bioavailability of Olanzapine is reduced by 50-60% when it is given with activated charcoal. 

 

When used with centrally acting medications and alcohol, Olanzapine should be used with caution.

Contraindications

Olanzapine is not recommended for individuals who have a known hypersensitivity to any of the product's ingredients or who are at risk for narrow-angle glaucoma.

Side Effects

Somnolence and weight gain are two of the most prevalent side effects. 

Aside from increased appetite, elevated glucose levels, elevated triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, and mild and transient anticholinergic effects such as constipation and dry mouth, asthenia, edema, and photosensitivity reaction, mild and transient anticholinergic effects such as constipation and dry mouth, asthenia, edema, and photosensitivity reaction may be observed.

Pregnancy & Lactation

Only if the possible advantages outweigh the danger to the fetus should olanzapine be taken during pregnancy. As a result, people should inform their doctors if they get pregnant or plan to become pregnant while taking Olanzapine. There is no evidence of teratogeneity in the report. If you're on Olanzapine, you shouldn't breastfeed.

 

 

 

 

Precautions & Warnings

In individuals with a history of seizures or disorders linked to seizures, olanzapine should be taken with caution. Olanzapine should be used with caution in patients with low leukocyte and/or neutrophil counts for any reason, drug induced bone marrow depression/toxicity caused by radiation therapy or chemotherapy, hypereosinophilic conditions, impaired hepatic function, and patients taking hepatotoxic medicines, as well as patientstaking centrally acting drugs and medicines known to prolong the QT interval, especially in the elderly. Patients should be warned about operating potentially dangerous machinery, such as automobiles.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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Check our pricing section for Oleanz 10mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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