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✅ Description:
Indications
An atypical antipsychotic is lurasidone hydrochloride. This medication is used to treat schizophrenia, depressive episodes associated with Bipolar I Disorder (bipolar depression), and as a monotherapy or in combination with lithium or valproate to treat bipolar depression.
Pharmacology
Lurasidone's effectiveness in schizophrenia may be mediated through antagonism of central Dopamine D2 and Serotonin 5HT2A receptors.
Dosage & Administration
Schizophrenia-
Starting Dose: 40 mg once daily
Recommended Dose: 40 mg to 160 mg once daily
Bipolar Depression-
Starting Dose: 20 mg once daily
Recommended Dose: 20 mg to 120 mg once daily
Lurasidone should be taken with food. Administration with food substantially increases the absorption of Lurasidone.
Interaction
When taking Lurasidone with mild CYP3A4 inhibitors, the dose should be reduced to half of what it was previously (e.g., Diltiazem, Atazanavir, Erythromycin, Fluconazole, Verapamil, etc.). If Lurasidone is taken with a moderate CYP3A4 inducer, the dose of Lurasidone may need to be increased.
Grapefruit and grapefruit juice should be avoided by Lurasidone patients because they can inhibit CYP3A4 and change Lurasidone concentrations.
Contraindications
Hypersensitivity. Strong CYP3A4 inhibitors given at the same time (eg, Ketoconazole). Strong CYP3A4 inducers given at the same time (eg, Rifampin). Psychosis caused by dementia.
Side Effects
Somnolence, akathisia, extrapyramidal symptoms, and nausea are among symptoms to look out for.
Pregnancy & Lactation
Pregnancy Classification B. Lurasidone should only be used during pregnancy if the possible benefit outweighs the fetus's danger. If a patient is taking Lurasidone, they should not breastfeed their child.
Precautions & Warnings
Cerebrovascular complications in dementia-related psychosis in the elderly: Cerebrovascular adverse events are becoming more common (e.g., stroke, transient ischemic attack).
Neuroleptic malignant syndrome: Stopping the medication right away and keeping a careful eye on it is the best way to handle it.
If clinically appropriate, discontinue if you have tardive dyskinesia.
Atypical antipsychotic medicines have been linked to metabolic changes that have been linked to an increased risk of cardiovascular and cerebrovascular disease. Hyperglycemia, dyslipidemia, and weight gain are all examples of metabolic alterations.
Hyperglycemia and diabetes mellitus: Keep an eye on patients for hyperglycemia signs such polydipsia, polyuria, polyphagia, and weakness. Patients with diabetes or those at risk for diabetes should have their glucose levels checked on a regular basis.
Dyslipidemia: Patients on atypical antipsychotics have shown to have undesirable changes in their lipid profiles.
Weight Gain: There has been an increase in body weight. Keep an eye on your weight.
Prolactin increases are possible in hyperprolactinemia.
Storage Conditions
S Store below 30° C and away from light and moisture. Keep out of children's reach.
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