Mifeston 200mg Tablet (3pcs Box)

Uses of Mifeston 200mg Tablet

Medical Abortion

How does

Mifepristone is an abortion pill that blocks the actions of the hormone progesterone, essential for maintaining pregnancy. This leads to the shedding of the uterine lining, making it challenging for the fetus to implant and grow. Additionally, it elevates levels of prostaglandins in the uterus, which can disrupt uterine membranes, resulting in abortion.

Side Effects of Mifeston 200mg Tablet

Common side effects include uterine contractions, cramping, and bleeding. Heavy bleeding may occur in some cases. Rare adverse effects encompass uterine rupture, hypotension, skin rashes, urticaria, hot flashes, and dizziness.

Quick Suggestions:

• Avoid consuming grapefruit or grapefruit juice while taking mifepristone, as it may interfere with the metabolism of the medication
• Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if your nausea worsens
• Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes
• Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness

Indication

Mifepristone is a medication used as a non-surgical alternative for ending intrauterine pregnancies. It can be employed in the following scenarios:

Medical Termination of Pregnancy: Mifepristone is used to terminate early intrauterine pregnancies. A single oral dose of 600 mg is followed by the administration of a prostaglandin analog like Misoprostol or Gemeprost after 36-48 hours.

Cervical Softening and Dilation: Mifepristone is used to prepare the cervix for surgical pregnancy termination. A dose of 200 mg is administered 36-48 hours before the surgical procedure.

Preparation for Prostaglandin Analog Use: It is employed to prepare for prostaglandin analog administration in the medical termination of pregnancy. A 600 mg dose of Mifepristone is taken as a single oral dose 36-48 hours before scheduled prostaglandin administration.

Labor Induction for Expulsion of Deceased Fetus: In cases of fetal death in utero, Mifepristone is administered as a 600 mg single oral dose for two consecutive days. If labor does not commence within 72 hours after the first dose, traditional labor-inducing methods are used.

Pharmacology

Mifepristone competitively binds to intracellular progesterone receptors, suppressing progesterone's actions. It increases the sensitivity of the myometrium to prostaglandin-induced contractions and blocks cortisol function at the glucocorticoid receptor.

Dosage & Administration of Mifeston 200mg Tablet

The dosage and administration of Mifepristone differ based on its use. In medical termination of pregnancy, it's taken as a 600 mg single oral dose followed by prostaglandin analog administration. It's crucial to follow the specific dosing instructions provided by a healthcare professional.

Interaction

Ketoconazole, itraconazole, erythromycin, grapefruit juice, rifampicin, dexamethasone, St. John's Wort, and various anticonvulsants can interact with Mifepristone, impacting its metabolism.

Contraindications

Mifepristone is contraindicated in cases of uncertain pregnancy or suspicion of ectopic pregnancy. It should not be used if the pregnancy has advanced beyond specific gestational limits or in various medical conditions. It must never be prescribed to patients with chronic adrenal failure, known allergies to Mifepristone, severe uncontrolled asthma, porphyrias, renal or hepatic failure, or during breastfeeding.

Pregnancy & Lactation

Mifepristone is solely approved for use in pregnancy termination. It is not known to be excreted in human milk, but its impact on newborns is unclear, so women breastfeeding after Mifepristone use should consult their doctor.

Precautions & Warnings

Mifepristone should be administered under medical supervision and is not advised for patients with specific medical conditions. Patients over 35 years old and heavy smokers should be treated cautiously. The effectiveness of Mifepristone may be reduced if Misoprostol is administered more than two days after Mifepristone.

Storage Conditions

Store Mifepristone at 25°C.