Stener 150mg Tablet 10pcs

Uses of Stener 150mg Tablet

• Dissolution Of Cholesterol Gallstones
• Primary Biliary Cirrhosis

How does Stener 150mg Tablet work?

This medication decreases the cholesterol content of bile and bile stones by reducing the secretion of cholesterol from the liver and the fractional reabsorption of cholesterol by the intestines

Side Effects of Stener 150mg Tablet

• Diarrhea
• Nausea
• Abdominal Pain
• Fatigue
• Headache
• Pruritus
• Rash
• Vomiting
• Dyspepsia
• Metallic Taste

Quick Suggestions:

• Stener 150 should be taken after a meal with a glass of milk or water.
• Eat a healthy diet, exercise regularly, and avoid alcohol intake.
• Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
• Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
• Do not stop taking the medication without talking to your doctor.

Indication of Stener 150mg Tablet

Ursodeoxycholic Acid is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones, and Non-Alcoholic Steato Hepatitis (NASH).

Pharmacology

Ursodeoxycholic Acid (UDCA) is a naturally occurring bile acid used to treat various hepatobiliary disorders. Its mechanism of action involves several pathways:

• Decrease in Cholesterol Secretion: UDCA reduces the secretion of cholesterol in bile, which helps in preventing the formation of cholesterol gallstones.
• Reduction in Cholesterol Absorption: UDCA reduces the absorption of cholesterol from the intestine, further contributing to the prevention of gallstone formation.
• Suppression of Liver Cholesterol Synthesis: UDCA suppresses the synthesis of cholesterol in the liver, which is another mechanism by which it reduces cholesterol levels in bile.
• No Inhibition of Bile Acid Synthesis: Unlike some other medications, UDCA does not inhibit the synthesis of bile acids. This alteration in bile composition from supersaturated to unsaturated helps in preventing gallstone formation.
• Promotion of Cholesterol Crystal Complex Formation: UDCA promotes the formation of liquid cholesterol crystal complexes, facilitating the removal of cholesterol from the gallbladder into the intestine for expulsion.

UDCA provides therapeutic benefits in cholestatic liver diseases through several mechanisms:

Protection of Cholangiocytes: UDCA protects cholangiocytes (cells lining the bile ducts) against the cytotoxicity of hydrophobic bile acids, which helps in maintaining bile flow and preventing bile duct damage.

Stimulation of Hepatobiliary Secretion: UDCA stimulates the secretion of bile from hepatocytes (liver cells) into the bile ducts, aiding in the elimination of bile acids and waste products from the liver.

Protection against Bile Acid-Induced Apoptosis: UDCA protects hepatocytes against bile acid-induced apoptosis (cell death), thereby preserving liver function and preventing liver damage.

After oral administration, UDCA is completely absorbed in the upper intestine. The time to peak serum concentration varies from 30 to 150 minutes, with a rate of absorption ranging from 60-80%. Once absorbed, UDCA enters the portal vein and undergoes extraction from portal blood by the liver. In the liver, UDCA is conjugated with amino acids, such as glycine or taurine, and then secreted into the hepatic bile ducts. Small quantities of UDCA appear in the circulation, and very small amounts are excreted into the urine. The biological half-life of UDCA ranges from 3.5 to 5.8 days, indicating its relatively long duration of action.

Dosage & Administration of Stener 150mg Tablet

The recommended dosage of Ursodeoxycholic Acid (UDCA) varies depending on the specific condition being treated. Here are the dosage recommendations for different indications:

• Dissolution of Gallstones: The typical dosage is 8-12 mg/kg/day, either as a single nighttime dose or divided into multiple doses throughout the day.
• Primary Biliary Cholangitis (PBC): The usual dosage ranges from 10-15 mg/kg/day, divided into 2-4 doses throughout the day.
• Acute Viral Hepatitis: The recommended dosage is 600 mg/day.
• Alcoholic Fatty Liver Disease: The typical dosage is 300 mg/day.
• Primary Sclerosing Cholangitis (PSC): The usual dosage ranges from 25-30 mg/kg/day.
• Non-Alcoholic Steatohepatitis (NASH): The typical dosage ranges from 13-15 mg/kg/day.

Interaction

Before taking URSODIL 300MG TABLET, it's crucial to inform your doctor about any other medications you are currently taking to avoid potential drug interactions. Here are some medications that may interact with Stener 150mg Tablet:

• Medicines used for birth control: Certain contraceptives containing levonorgestrel or ethinyl estradiol may interact with Stener 150mg Tablet.
• Medicines used to treat acidity: Antacids containing aluminum hydroxide may interact with Stener 150mg Tablet.
• Medicines used to lower cholesterol levels: Medications such as colestyramine, clofibrate, and colestipol, which are used to lower cholesterol levels, may interact with Stener 150mg Tablet.
• Medicines used to treat infections: Antibiotics like ciprofloxacin and dapsone, used to treat infections, may interact with Stener 150mg Tablet.
• Medicine used to treat hypertension: Blood pressure medications such as nitrendipine and rosuvastatin may interact with Stener 150mg Tablet.
• Medicines used to reduce the activity of the immune system: Immunosuppressive drugs like ciclosporin may interact with Stener 150mg Tablet.

Contraindications:

• Allergy to bile acids.
• Calcified gallstones.
• Inflammation of the gallbladder or the bile ducts.
• Blockage of the common bile duct or cystic duct.
• Frequent cramp-like pains in the upper abdomen.
• Low bile flow in children.
• Improper function of the gall bladder.
• Use with caution in patients with liver diseases.

Pregnancy & Lactation

• Should be taken during pregnancy only if advised by the doctor.
• Use with caution in breastfeeding women. Ask your doctor’s advice before taking it.

Precautions & Warnings

• Dietary restrictions: Avoid excessive intake of calories and cholesterol-rich foods while taking Stener to optimize its effectiveness.
• Monitoring liver function: Liver function tests (LFTs) and bilirubin levels should be monitored regularly, particularly during the initial months of therapy. This helps assess the drug's impact on liver function and detect any abnormalities early on.
• Risk of gallstone recurrence: Despite successful treatment, there is a risk of gallstone recurrence in some patients. Approximately 50% of successfully treated patients may develop further gallstones within 10 years.
• Pregnancy and lactation: Use caution if you are pregnant or breastfeeding while taking StenerL. It's essential to discuss the potential risks and benefits with your doctor before initiating treatment during pregnancy or lactation.
• Monitoring parameters: Monitor liver function tests monthly for the first three months of treatment, and then every six months thereafter. Regarding lactation, it's unclear if Stener is excreted in breast milk, so caution is advised.

Storage Conditions

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.