Generic Name: Levofloxacin Hemihydrate 500mg
Manufacturer/Distributor: Beacon Pharmaceuticals Limited
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Indications
An antibiotic called Quixin 500 is used to treat bacterial infections. Additionally, it is used to treat infections of the lungs, nose, throat, skin, and soft tissues (pneumonia). By preventing the growth of the causing germs, it treats the infection.
Pharmacology
Levofloxacin is a third-generation fluoroquinolone antibiotic that is synthetic and broad-spectrum. Levofloxacin is a chiral fluorinated carboxy quinolone chemically. The enzymes essential for DNA replication, transcription repair, and recombination, bacterial topoisomerase IV and DNA gyrase, are inhibited by levofloxacin. It shows activity against a variety of gm-ve and gm+ve bacteria in vitro.
Dosage & Administration
The usual dose of Levofloxacin Tablets is 250 mg or 500 mg or 750 mg administered orally every 24 hours. Levofloxacin tablets can be administered without regard to food. Levofloxacin oral solution should be taken 1 hour before, or 2 hours after eating.
Levofloxacin injection should only be administered by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration. The usual dose of Levofloxacin injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours. Since the Levofloxacin injections are for single use only, any unused portion should be discarded. Additives or other medications should not be added to Levofloxacin Injection or infused simultaneously through the same intravenous line.
Adults:
Children:
In each case, sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.
Instructions for the Use of Levofloxacin Infusion-
Interaction
Through the same intravenous line, no quinolone should be given with any solution containing multivalent cations, such as magnesium. Levofloxacin absorption is hampered by antacids, iron, and adsorbents. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may raise the risk of CNS stimulation. Warfarin might make you bleed more easily.
Contraindications
Patients having a history of hypersensitivity to levofloxacin, quinolone antibiotic drugs, or any other component of this medication should not use it.
Side Effect
Levofloxacin is well tolerated by most people. However, there are typically a few adverse effects. Retinal detachment is a possibility. Nausea, vomiting, diarrhea, stomach discomfort, flatulence, and phototoxicity are some of the other adverse effects (0.1 percent ). Tremors, sadness, anxiety, and disorientation are some of the uncommon side effects that may occur.
Pregnancy & Lactation
Because the effects on the unborn child or nursing infant are unclear, levofloxacin is not advised for use during pregnancy or breastfeeding.
Precautions & Warnings
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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