Injection Manufacturer/Distributor: Square Pharmaceuticals Ltd. Generic Name: Flucloxacillin 500 mg/vial Injection
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Flucloxacillin is used to treat infections produced by Gram-positive bacteria, particularly infections caused by staphylococci that produce penicillinase. These are some of the signs:
Infections of the skin and soft tissues: boils, abscesses, carbuncles, and infected skin diseases (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo). Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy are all respiratory tract illnesses. It is also used to treat other infections caused by Flucloxacillin-sensitive organisms, such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, and septicaemia. When appropriate, it is utilized as a preventive medication during major surgical procedures such as cardiothoracic and orthopedic surgery.
Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci.
Flucloxacillin kills bacterial cellwall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacillin. As a result the bacterial cellwall is weakened, the cell swells and then ruptures. Flucloxacillin resists the action of bacterial penicillinase probably because of the steric hindrance induced by the acyl side chain which prevents the opening of the β-lactam ring.
Oral administration:
Parenteral administration:
Adult or Elderly:
Children:
Concurrent Flucloxacillin use may result in an elevated Flucloxacillin level in the blood for an extended period of time.
Flucloxacillin is not recommended for people who are allergic to penicillin.
Nausea, vomiting, diarrhoea, dyspepsia, and other minor gastrointestinal disturbances are some of the most common gastrointestinal side effects. Urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice have all been reported in addition to these rashes.
Flucloxacillin is classified as a pregnancy category B by the US Food and Drug Administration. In pregnant women, there are no adequate and well-controlled studies. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary.
In patients with hepatic dysfunction, flucloxacillin should be used with caution. In the treatment of patients with allergic diathesis, caution is also advised.
Penicillinase-resistant penicillins
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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