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Tablet. Generic Name: Metronidazole
indications:All forms of amoebiasis (intestinal and extra-intestinal disease including liver abscess and that of symptomless cyst passers) Trichomoniasis Giardiasis Bacterial vaginosis Acute ulcerative gingivitis Anaerobic infections including septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis etc. Anaerobically-infected leg ulcers and pressure sores Acute dental infections (e.g. acute pericoronitis and acute apical infections) Surgical prophylaxis (prevention of postoperative infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic streptococci Chronic symptomatic peptic ulcer disease (as an agent of triple therapy to eradicate H. pylori-the most important aetiological factor of peptic ulcer)
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✅ Description:
Dosage:
Oral-
Amoebiasis:- Adult: 800 mg tid for 5 days (intestinal infection); 5-10 days (extra-intestinal infection). Max: 2.4 g/day.
- Child: 1-3 yr 100-200 mg tid; >3-7 yr 100-200 mg 4 times daily; >7-10 yr 200-400 mg tid. Doses are given for 5-10 days.
- Adult: 400 mg 8 hrly 24 hr prior to surgery followed by post-op IV or rectal admin until oral therapy is possible.
- Child:
- Adult: 2 g once daily for 3 days, 400 mg tid for 5 days or 500 mg bid for 7-10 days.
- Child: 1-3 yr 500 mg once daily; >3-7 yr 600-800 mg once daily; >7-10 yr 1 g once daily. Doses are given for 3 days.
- Adult: Initially, 800 mg followed by 400 mg 8 hrly. Alternatively, 7.5 mg/kg 6-8 hrly. Max: 4 g/day. Duration of treatment is usually for 7 days depending on the severity of infection.
- Child:
- Adult: 2 g as a single dose or 400 mg bid for 5-7 days.
- Adult: 2 g as a single dose, 200 mg tid for 7 days or 400 mg bid for 5-7 days. Sexual partners should also be treated. Repeat treatment 4-6 wk between courses as necessary.
- Child: 1-10 yr 40 mg/kg as a single dose or 15-30 mg/kg daily in 2-3 divided doses for 7 days. Max: 2 g/dose.
- Adult: 400 mg tid for 7 days.
- Adult: 400 mg bid in combination with another antibacterial and a PPI or 400 mg tid, if given with omeprazole and amoxicillin. Initial treatment is given for 1 wk.
- Adult: 200 mg tid for 3 days.
- Child: 1-3 yr 50 mg tid; >3-7 yr 100 mg bid; >7-10 yr 100 mg tid. Doses are given for 3 days.
- Adult: 200 mg tid for 3-7 days.
Intravenous-
Prophylaxis of postoperative anaerobic bacterial infections:- Adult: 500 mg shortly before operation and repeated 8 hrly. Alternatively, 15 mg/kg infused over 30-60 min and completed approx 1 hr before surgery, followed by 7.5 mg/kg infused over 30-60 min at 6 and 12 hr after the initial dose.
- Adult: 500 mg infused as 100 mL of a 5 mg/mL soln at 5 mL/min 8 hrly. Alternatively, 15 mg/kg infused over 1 hr, followed by 7.5 mg/kg infused over 1 hr 6 hrly. Max: 4 g/day. Substitute oral therapy as soon as possible.
- Child: 7.5 mg/kg 8 hrly.
Rectal-
Anaerobic infections:- Adult: 1 g 8 hrly for 3 days, then 12 hrly thereafter until oral medication is possible.
- Child: 5-10 yr 500 mg. All doses to be given 8 hrly for 3 days, then 12 hrly thereafter until oral medication is possible.
- Adult: 1 g 2 hr before surgery, repeated 8 hrly for 3 days, then 12 hrly thereafter until oral medication is possible.
- Child: 5-10 yr 500 mg 2 hr before surgery, repeated 8 hrly for 3 days, then 12 hrly thereafter until oral medication is possible.
Topical/Cutaneous (Adult)-
- Rosacea: As 0.75% gel/cream/lotion: Apply thinly to the affected area bid for 8 wk, further applications may be necessary depending on the severity of the infection.
- Bacterial vaginosis: As 0.75% gel: Apply to affected area intravaginally once daily or bid for 5 days.
- Fungating tumours: As 0.75% gel: Apply over the complete area and cover w/ non-adherent dressing. Use 1-2 times daily as necessary.
Side Effects:Side effects of Metronidazole include gastrointestinal discomfort, nausea, coated tongue, dryness of mouth and unpleasant metallic or bitter taste, headache, pruritus and skin rashes and less frequently, vertigo, depression, insomnia, drowsiness, urethral discomfort, and darkening of the urine. Occasionally there may be temporary moderate leucopenia. Peripheral neuropathy has been reported in patients on prolonged therapy.
Store between 15-30° C. Protect from light.
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