Generic Name: Flucloxacillin 500mg
Manufacturer/Distributor: Popular Pharmaceuticals Ltd.
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Indications
Pharmacology
Flucloxacillin is active against gram-positive bacteria, including penicillinase-producing strains. It has little activity against gram-negative rods. Flucloxacillin works by inhibiting the formation of bacterial cell walls. Flucloxacillin is isoxazole penicillin, which combines resistance to enzymatic hydrolysis of penicillin, gastric acid stability, and activity against Gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful for Staphylococcus which produces penicillinase. Flucloxacillin destroys the bacterial cell wall, which interferes with peptidoglycan synthesis. Peptidoglycan is a heteromeric structure that provides mechanical stability to the cell wall. The final step of peptidoglycan synthesis involves the completion of cross-linking with the terminal glycine residue of the pentaglycine bridge connected to the fourth pentapeptide residue (Dalanin). The transpeptidase that performs this step is inhibited by flucloxacillin. As a result, the bacterial cell wall weakens, the cell swells and then breaks down. The effect of flucloxacillin against bacterial penicillinase may be due to the steric hindrance caused by the acyl side chain preventing the opening of the β-lactam ring.
Dosage & Administration
Oral administration:
Parenteral administration:
Adult or Elderly:
Intravenous Injection:
All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.
Children:
Interaction
Concurrent use of Flucloxacillin and may result in increased levels of Flucloxacillin in the blood for a prolonged period.
Contraindications
Flucloxacillin is contraindicated in penicillin-hypersensitive patients.
Side Effects
Nausea, vomiting, diarrhea, dyspepsia, and other minor gastrointestinal problems are some of the most prevalent gastrointestinal side effects. Urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice have all been documented in addition to these rashes.
Pregnancy & Lactation
Nausea, vomiting, diarrhea, dyspepsia, and other minor gastrointestinal problems are some of the most prevalent gastrointestinal side effects. Urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice have all been documented in addition to these rashes.
Precautions & Warnings
In patients with hepatic impairment, flucloxacillin should be taken with caution. In the treatment of patients with allergic diathesis, caution is also advised.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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