Manufacturer/Distributor: Beximco Pharmaceuticals Ltd.
Generic Name: Atenolol 50 mg Tablet
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Lonet 50 is indicated-
Atenolol was created as a result of attempts to create a -adrenoceptor antagonist that would block 1 (cardiac) receptors while having no impact on 2-receptors. It's a 1 selective (cardioselective) -adrenergic receptor antagonist that doesn't have any membrane stability or partial agonist action. It is the most hydrophilic of the currently available - blockers, and as a result, it penetrates cell membrane lipids poorly.
Hypertension: The initial dose of Atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.
Angina Pectoris: The initial dose of Atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect. Twenty-four-hour control with once-daily dosing is achieved by giving doses larger than necessary to achieve an immediate maximum effect. The maximum early effect on exercise tolerance occurs with doses of 50 to 100 mg, but at these doses, the effect at 24 hours is attenuated, averaging about 50% to 75% of that observed with once-a-day oral doses of 200 mg.
When taken with beta-blocking medicines, catecholamine-depleting pharmaceuticals (e.g., reserpine) may have an additive impact. Patients taking Atenolol in combination with a catecholamine depletion should be constantly monitored for signs of hypotension and/or significant bradycardia, which can cause vertigo, syncope, or postural hypotension.
When used with Atenolol, calcium channel blockers may have an additional impact.
Disopyramide is a Type I antiarrhythmic with strong inotropic and chronotropic unfavorable effects. When used with beta-blockers, disopyramide has been linked to severe bradycardia, asystole, and cardiac failure.
Amiodarone is an antiarrhythmic medication having a negative chronotropic potential.
Sinus bradycardia, first-degree heart block, cardiogenic shock, and overt cardiac failure are all contraindications to taking atenolol.
Patients who have previously had hypersensitivity to Lonet 50 or any of the drug's components.
Pregnancy Category D. Caution should be exercised when Atenolol is administered to a nursing woman. Clinically significant bradycardia has been reported in breast-fed infants. Premature infants, or infants with impaired renal function, may be more likely to develop adverse effects.
Patients who are already on a beta-blocker should be carefully assessed before receiving Atenolol. Depending on clinical data such as pulse and blood pressure, the initial and subsequent Atenolol dosages can be adjusted downward. Atenolol can make circulation problems in the peripheral arteries worse.
Impaired Renal Function: Patients with impaired renal function should use the medication with caution.
Beta-adrenoceptor blocking drugs, Beta-blockers
Store in a dry area at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children's reach.
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