Duocard 10mg 10pcs

Indications of Duocard 10

A drug called Duocard 10 is used to treat high blood pressure (hypertension). It is a member of the calcium channel blocker drug class, which lowers blood pressure. By doing this, heart attacks and strokes are reduced. Additionally, it may be used to stop angina (heart-related chest pain).

Pharmacology

Cilnidipine is a calcium channel blocker that is made up of dihydropyridines. Cilnidipine binds to the dihydropyridine binding sites of the L-type voltage-dependent calcium channel, inhibiting Ca2+ influx across the cell membranes of vascular smooth muscle cells, and inducing vasodilation. Cilnidipine blocks Ca2+ influx through sympathetic nerve cell membrane N-type voltage-dependent calcium channels. N-type voltage-dependent calcium channel inhibition was reported over a comparable range of medication doses as L-type voltage-dependent calcium channel inhibition. As a result, norepinephrine release from sympathetic nerve terminals would be reduced. Cilnidipine is thought to reduce the reflex rise in heart rate that occurs after blood pressure is reduced.

Dosage & Administration

• Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily.
• Pediatric use: The safety of Cilnidipine in pediatric patients has not been established.
• Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).

Interaction of Duocard 10

Quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin are examples of antihypertensive and antipsychotic drugs that cause hypotension.

Contraindications

Individuals with known hypersensitivity to cilnidipine or any of the excipients, as well as patients with cardiogenic shock, recent MI, acute unstable angina, and severe aortic stenosis, should not take it.

Side Effects of Duocard 10

Dizziness, hot flashes, headache, hypotension, peripheral edema, palpitations, gastrointestinal issues, increased frequency of urination, lethargy, eye pain, and depression are the most prevalent Cinidipine side effects.

Pregnancy & Lactation

Women who are pregnant or who may become pregnant should not take cilnidipine. It is also recommended to avoid taking Cinidipine to breastfeeding mothers. However, if the administration is necessary, patients should be instructed to stop breastfeeding.

Precautions & Warnings

Cinidipine should be used with caution in the following patients: patients with severe hepatic impairment, and patients with a history of serious adverse reactions to calcium channel blockers. During the waiting period, the dose should be gradually reduced under close observation.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep away from reaching out to the children.