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Coversyl is a long-acting ACE inhibitor used in the management of:
- Essential Hypertension
- Stable Coronary Artery Disease
- Congestive Heart Failure
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â Description:
Perindopril lowers blood pressure by inhibiting the angiotensin-converting enzyme (ACE), responsible for producing angiotensin II â a substance that tightens blood vessels. By blocking ACE, perindopril decreases angiotensin II levels, promoting vasodilation (widening of blood vessels), which leads to reduced blood pressure and improved blood flow.
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âī¸ Side Effects
Common (especially during early therapy):
Cough, fatigue, weakness, headache, mood, or sleep disturbances
Less Common:
Altered taste, nausea, indigestion, abdominal pain, skin rashes
Mild increase in blood urea/creatinine levels
Occasional proteinuria
Rare:
Angioedema
Decreased hemoglobin, red blood cells, or platelets
âī¸ Dosage & Administration
General Rule: Coversyl should be taken once daily, preferably in the morning before meals.
For Hypertension
Start with 4 mg once daily
If needed, increase to 8 mg once daily after 1 month
For Stable Coronary Artery Disease
Begin with 4 mg once daily for 2 weeks
Increase to 8 mg once daily, depending on kidney function and tolerance
Elderly patients: Start with 2 mg daily for one week, then 4 mg the next week before escalating to 8 mg
For Congestive Heart Failure
Initiate under medical supervision with 2 mg once daily
If required, the dose may be increased to 4 mg once daily
Elderly Patients
Start with a low dose (â¤4 mg/day)
Increase dosage gradually as needed
Use caution with doses above 8 mg, as clinical data is limited
âī¸ Drug Interactions
- With Diuretics: May amplify the blood pressure-lowering effect; stop diuretics 3 days prior to starting Coversyl if possible
- With Potassium Supplements or Potassium-Sparing Diuretics: Increased risk of hyperkalemia
- With Lithium: May elevate lithium levels and toxicity
- With NSAIDs (e.g., ibuprofen, aspirin): May reduce antihypertensive effect and increase risk of kidney impairment
- With Antidiabetics: May heighten the risk of hypoglycemia
- With Gold Compounds (e.g., sodium aurothiomalate): May provoke rare nitritoid reactions
âī¸ Contraindications
- Known allergy or hypersensitivity to Perindopril
- Not recommended for children
- Pregnancy and lactation â strictly contraindicated
âī¸ Pregnancy & Lactation
Not to be used during pregnancy or while breastfeeding, due to potential risks to the fetus or infant.
âī¸ Use with caution in:
- Renal impairment or renovascular hypertension
- Patients undergoing surgery or under anesthesia
- Those with volume depletion or on diuretics (may cause first-dose hypotension)
- Before starting in diuretic-treated patients: Withhold the diuretic 3 days prior if possible
- Avoid combining with potassium-sparing diuretics
- Caution with neuroleptics or tricyclic antidepressants, which may intensify hypotensive effects
- Monitor serum lithium levels if co-administered with lithium
âī¸ Storage Conditions
- Store at temperatures below 30°C
- Protect from light and moisture
- Keep out of reach of children
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
