✔ 100% Authentic Product
👁️ Currently Viewing 327
Abetis is prescribed for the management of high blood pressure (hypertension). It can be used as a standalone treatment or combined with other antihypertensive medications.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
ফ্রি ডেলিভারি! - ১৪৯৯ টাকা+ অর্ডারে ঢাকা
শহরে ।- ফ্রি ডেলিভারি! - ২৯৯৯ টাকা+ অর্ডারে ঢাকার
বাহিরে ।
✅ Description:
Olmesartan medoxomil is an angiotensin II receptor blocker (ARB). Angiotensin II, a potent vasoconstrictor, is formed from angiotensin I via the enzyme ACE (angiotensin-converting enzyme). It plays a critical role in regulating blood pressure by constricting blood vessels, promoting aldosterone secretion, increasing sodium reabsorption in the kidneys, and stimulating the heart.
Olmesartan selectively blocks angiotensin II from binding to AT₁ receptors on vascular smooth muscles, thereby preventing vasoconstriction. While AT₂ receptors exist in various tissues, they are not directly involved in blood pressure regulation. Olmesartan has a very high affinity for AT₁ receptors—over 12,500 times greater than for AT₂ receptors.
Unlike ACE inhibitors, olmesartan does not inhibit kininase II, so it does not interfere with bradykinin responses. Though blocking angiotensin II receptors may increase renin activity and circulating angiotensin II levels, these do not negate its antihypertensive action.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Common Side Effect: Dizziness (3% in Abetis vs. 1% in placebo).
Other Reported Reactions: Back pain, bronchitis, increased creatine phosphokinase, diarrhea, headache, hematuria, hyperglycemia, elevated triglycerides, flu-like symptoms, pharyngitis, rhinitis, and sinusitis. The incidence of cough was similar in both treatment (0.9%) and placebo (0.7%) groups.
✔️ Dosage & Administration
Initial Dose: 20 mg once daily for patients not volume-depleted.
Titration: If further blood pressure reduction is needed after 2 weeks, the dose may be increased to 40 mg once daily. Doses beyond 40 mg do not enhance efficacy.
Dosing Frequency: Twice-daily dosing offers no added benefit over once-daily administration.
No initial dose adjustment is required for elderly patients or those with moderate-to-severe renal (CrCl <40 mL/min) or hepatic impairment. However, patients with reduced intravascular volume (e.g., those on diuretics) should start treatment under medical supervision, possibly at a lower dose. The medication can be taken with or without food.
Pediatric Use: Safety and effectiveness in children have not been established.
✔️ Drug Interactions
No significant interactions were observed when used with digoxin, warfarin, or antacids.
Olmesartan is not processed by the cytochrome P450 enzyme system, so interactions with drugs affecting this system are unlikely.
Co-use with NSAIDs (including COX-2 inhibitors) in elderly, volume-depleted, or renally impaired patients may worsen renal function or lead to acute renal failure. These effects are typically reversible.
NSAIDs may reduce the antihypertensive efficacy of olmesartan. Renal function should be monitored during such combined therapy.
✔️ Overdose Management
There are no documented cases of olmesartan overdose. Likely symptoms include hypotension and increased heart rate; bradycardia may occur due to vagal activation. If the overdose is recent, consider gastric lavage or induced vomiting. Significant hypotension should be treated with cardiovascular support, including monitoring vital signs, elevating limbs, and ensuring adequate fluid and urine output.
✔️ Use During Pregnancy & Lactation
Discontinue Abetis as soon as pregnancy is detected. Use during the second and third trimesters can cause serious harm or death to the fetus. Though not confirmed in humans, olmesartan is excreted in the milk of lactating rats. Due to potential risks to nursing infants, consider whether to stop breastfeeding or discontinue the drug, based on its necessity for the mother.
✔️ Precautions & Warnings
Olmesartan may impact kidney function, especially in patients dependent on the renin-angiotensin-aldosterone system (such as those with severe heart failure). It may lead to reduced urine output, azotemia, and rarely, acute kidney failure or death. These outcomes are more likely in susceptible individuals and should be monitored closely.
✔️ Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
