Estracon 0.625mg Tablet | Conjugated Estrogen | Buy Now | ePharma
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Estracon 0.625mg Tablet

Generic: Conjugated Estrogen

Type: Tablet

Pack Size: 10 Pcs

Estracon 0.625mg Tablet (Conjugated Estrogens 0.63mg) is a blend of estrogen hormones used to treat hormone-related conditions like osteoporosis (causing brittle bones), certain breast and prostate cancers, and menopausal symptoms such as hot flashes, vaginal dryness, and itching. It works by restoring estrogen levels in the body. 


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Description:

Estracon 0.625mg Tablet is categorized as hormone replacement therapy (HRT) to address menopause-related symptoms and conditions. The decline in estrogen levels during menopause can result in hot flushes and increase the risk of osteoporosis. Estracon 0.625mg Tablet, containing 'conjugated estrogens,' acts as HRT by replenishing estrogen levels, regulating hormone secretion (LH and FSH), and alleviating menopause symptoms.

Dosage and treatment duration should adhere to your doctor's guidance, tailored to your health condition. Possible side effects include abnormal vaginal bleeding, breast changes, nausea, abdominal discomfort, headache, mood swings, and more.

Certain medical conditions, such as breast/endometrial cancer, clotting disorders, heart issues, and liver disease, warrant caution or avoidance of Estracon 0.625mg Tablet use. Pregnant and breastfeeding individuals should avoid this medication. In case of adverse reactions or allergies, promptly consult your doctor.

Should you experience specific symptoms, like jaundice, high blood pressure, migraines, pregnancy, blood clot signs, or sugar intolerance, immediate medical attention is advised

Safety Advices


Alcohol
CAUTION

Caution is advised when consuming alcohol with Estracon 0.625mg Tablet. Consult your doctor.


Pregnancy
CONSULT YOUR DOCTOR

Estracon 0.625mg Tablet is considered unsafe during pregnancy due to potential risks to the developing baby. It may be prescribed in rare life-threatening situations if the benefits outweigh the risks. Consult your doctor.


Breastfeeding
CONSULT YOUR DOCTOR

Estracon 0.625mg Tablet is likely safe during breastfeeding, with limited data suggesting minimal risk to the baby.


Driving
CAUTION

The impact of Estracon 0.625mg Tablet on driving ability is unknown. Avoid driving if you experience concentration or reaction-related symptoms.


Kidney
CONSULT YOUR DOCTOR

Estracon 0.625mg Tablet is likely unsafe for patients with kidney disease. Consult your doctor before use.


Liver
CONSULT YOUR DOCTOR

Estracon 0.625mg Tablet is probably unsafe for patients with liver disease. Consult your doctor before use.

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Uses of Estracon 0.625mg Tablet

It is used in postmenopausal women to:

  • Relieve menopausal symptoms
  • Prevent osteoporosis
How does Estracon 0.625mg Tablet work?

Estracon 0.625mg Tablet/supplements estrogen levels in the body, addressing hormonal deficiencies like menopause. This alleviates postmenopausal symptoms such as hot flashes, sleep issues, irritability, depression, and bone loss.

Side Effects of Estracon 0.625mg Tablet
  • Nausea
  • Stomach pain
  • Headache
  • Back pain
  • Depression,
  • Sleep problems (insomnia)
  • Breast pain
  • Vaginal spotting
  • Vaginal itching
  • Depression
  • Leg cramps
  • Abdominal cramp
  • Vaginal yeast infection
  • Vaginal burning sensation
  • Vaginal itching or discharge
  • Changes in your menstrual periods
  • Unusual vaginal bleeding
  • Changes in vision or speech
Quick Suggestions:
  • When giving blood for tests, inform your doctor that you are taking Estracon 0.625mg Tablet, as the medication may affect certain test results.
  • To promote bone health and reduce the risk of osteoporosis, consider taking calcium and vitamin D supplements. Osteoporosis is a condition that causes bones to become weak and brittle.
  • Conjugated Estrogens are used as part of hormone replacement therapy to relieve menopausal symptoms. They may also be prescribed to prevent osteoporosis in postmenopausal women at high risk of fractures.
  • Take Conjugated Estrogen at the same time every day to help you remember to take the medication.
  • If you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge, or vaginal discomfort while taking Conjugated Estrogen, inform your doctor.
  • Regular breast examinations are important, as Conjugated Estrogen may increase the risk of breast cancer.
  • Stop taking the medication and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These symptoms could indicate a blood clot in a vein.
  • Your doctor may recommend blood tests to assess the risks associated with taking Conjugated Estrogen. Regular monitoring and assessment are important to ensure your safety and well-being.
Indication

Estracon 0.625 is used to treat-

  • Post-Menopausal Symptoms: Estracon 0.625mg Tablet is used to alleviate symptoms experienced after menopause, such as hot flashes and vaginal dryness. Menopause is defined by the absence of menstrual periods for at least 12 consecutive months.
  • Female Hypogonadism: Female hypogonadism occurs when the ovaries produce inadequate amounts of sex hormones. Estracon 0.625mg Tablet is used to treat this condition by supplementing the deficient estrogen levels.
  • Palliative Treatment of Cancer: Estracon 0.625mg Tablet is employed in palliative care for individuals with breast or prostate cancer. Palliative care aims to provide relief from the symptoms and discomfort associated with cancer, helping to manage pain and other issues.
  • Primary Ovarian Failure: Also known as primary ovarian insufficiency (POI), this condition involves the ovaries ceasing normal function prematurely, leading to low estrogen levels and potential infertility.Estracon 0.625mg Tablet is used to treat the symptoms of this condition by increasing estrogen levels.
  • Vaginal Atrophy: Vaginal atrophy, or atrophic vaginitis, is characterized by the thinning and drying of the vaginal lining due to decreased estrogen levels. This can result in discomfort, itching, burning, and pain during sexual intercourse. Estracon 0.625mg Tablet helps alleviate these symptoms by replenishing estrogen levels.
  • Postmenopausal Osteoporosis: Postmenopausal osteoporosis occurs after menopause due to decreased estrogen levels, leading to weakened and brittle bones. Estracon 0.625mg Tablet is used to prevent and treat the symptoms of osteoporosis in postmenopausal women.
Pharmacology

Role of Endogenous Estrogens: Estrogens are crucial hormones in the female reproductive system. They play a significant role in the development and maintenance of reproductive organs and secondary sexual characteristics.

Metabolic Interconversion: Circulating estrogens are in a state of constant metabolic conversion. Estradiol is the primary and most potent intracellular estrogen. Other metabolites include estrone and estriol. Estradiol is more powerful at the receptor level compared to its metabolites.

Source of Estrogen: In cycling adult women, the ovarian follicle is the main source of estrogen secretion. The amount of estradiol released varies throughout the menstrual cycle.

Postmenopausal Estrogen Production: After menopause, the primary source of estrogen shifts. Most endogenous estrogen in postmenopausal women is produced by the conversion of androstenedione, secreted by the adrenal cortex, to estrone in peripheral tissues.

Estrogen Receptors: Estrogens exert their effects by binding to estrogen receptors in estrogen-responsive tissues. Two types of estrogen receptors have been identified, and their proportions vary in different tissues.

Feedback Mechanism: Circulating estrogens play a role in modulating the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This is achieved through a negative feedback mechanism, helping to regulate the hormonal balance.

Dosage & Administration of Atrizin 10mg Tablet

Estracon 0.625mg Tablet is a medication containing conjugated estrogens, and its dosing varies based on the specific condition being treated. Here's a summary of the dosages and guidelines you've mentioned:

Female Castration, Primary Ovarian Failure:

  • Dosage: 1.25 mg/day in a cyclical regimen.

Palliation in Prostate Carcinoma:

  • Dosage: 1.25-2.5 mg three times a day.

Female Hypogonadism:

  • Dosage: 0.3-0.625 mg/day in a cyclical regimen.
  • Progestin treatment is added once skeletal maturity is achieved.

Menopausal Vasomotor Symptoms:

  • Dosage: 0.45 mg/day, up to 1.25 mg/day.
  • Attempt to discontinue the medication at 3-6-month intervals.

Vulvular and Vaginal Atrophy:

  • Dosage: 0.3 mg/day.

Osteoporosis Prophylaxis in Postmenopausal Women:

  • Initial Dosage: 0.3 mg/day in a cyclical or continuous regimen depending on the patient's condition.

Please note the following important points:

  • Estracon 0.625mg Tablet is generally not recommended for use in children and adolescents (aged below 18 years of age).
  • Always consult your doctor before taking any medication, including Estracon 0.625mg Tablet.
  • Take Estracon 0.625mg Tablet exactly as advised by your physician.
  • Swallow the tablet with a glass of water. Do not crush or chew the tablet.
  • Take Estracon 0.625mg Tablet at the same time each day.
  • Do not miss any doses, as this may reduce its effectiveness.
  • If you miss a dose, take it as soon as you remember. Do not take a double dose to compensate for the missed dose.
  • Your doctor will determine the appropriate dose and duration of therapy based on factors like age, body weight, and health condition.

As always, it's important to follow your doctor's instructions and guidelines for medication use. If you have any questions or concerns about your medication regimen, don't hesitate to consult your healthcare provider for clarification and personalized guidance.

Interaction

Drug-Drug Interactions:

Before taking Estracon 0.625mg Tablet, it's important to inform your doctor if you are taking any of the following medications:

  1. Medicines used to treat epilepsy (e.g., phenobarbital, phenytoin, carbamazepine)
  2. Medicines used to treat tuberculosis (e.g., rifampicin, rifabutin)
  3. Medicines used to treat HIV infection (e.g., nevirapine, efavirenz, ritonavir, nelfinavir)
  4. Medicines used to treat bacterial infections (e.g., erythromycin, clarithromycin)
  5. Medicines used to treat fungal infections (e.g., ketoconazole, itraconazole)
  6. St. John's wort (an herbal medication used to treat depression)
  7. Metyrapone (used to treat adrenal insufficiency)
  8. Cimetidine (used to treat stomach ulcers)
  9. Dexamethasone (a corticosteroid used to treat inflammation)

Drug-Food Interaction:

Avoid drinking grapefruit juice while taking Estracon 0.625mg Tablet, as it may alter the effects of the medicine. Grapefruit or grapefruit juice should be avoided to reduce the risk of side effects.

Drug-Disease Interactions:

  • Breast cancer
  • Endometrial cancer (cancer of the lining of the womb)
  • Unexplained vaginal bleeding
  • Untreated endometrial hyperplasia (thickening of the womb lining)
  • Blood clot in the veins (thrombosis), including deep vein thrombosis or pulmonary embolism
  • Blood clotting disorder
  • Heart attack or angina (chest pain)
  • Inherited porphyria (a blood disorder)
  • Liver disease
Contraindications
  • Known or Suspected Pregnancy: Estracon 0.625mg Tablet should not be used in individuals who are known to be pregnant or suspected to be pregnant.
  • Undiagnosed Abnormal Uterine Bleeding: If an individual has undiagnosed abnormal uterine bleeding (bleeding that is not due to a regular menstrual period), the use of Estracon 0.625mg Tablet is not recommended until the cause of the bleeding is identified.
  • History of Breast Cancer: Individuals with a history of breast cancer should not use Estracon 0.625mg Tablet, as it is contraindicated.
  • Estrogen-Dependent Neoplasia: Known or suspected estrogen-dependent neoplasia, such as endometrial cancer or endometrial hyperplasia, is a contraindication for using Estracon 0.625mg Tablet.
  • Arterial Thromboembolic Disease: Individuals with a history of arterial thromboembolic disease (such as stroke or myocardial infarction) or venous thromboembolism (such as deep venous thrombosis or pulmonary embolism) should not use Estracon 0.625mg Tablet due to the risk of potentially worsening these conditions.
  • Active or Chronic Liver Dysfunction/Disease: Estracon 0.625mg Tablet is contraindicated in individuals with active or chronic liver dysfunction or disease.
  • Thrombophilic Disorders: Known thrombophilic disorders, including deficiencies of proteins like protein C, protein S, or antithrombin, are contraindications for the use of Estracon 0.625mg Tablet.
  • Hypersensitivity: Individuals who are hypersensitive (allergic) to any component of Estracon 0.625mg Tablet should not use this medication.
Pregnancy & Lactation

If pregnancy occurs during medication with Conjugated Oestrogens treatment should be withdrawn immediately. The results of most epidemiological studies to date relevant to inadvertent fetal exposure to estrogens indicate no teratogenic or foetotoxic effects.

Precautions & Warnings

Allergies: Inform your doctor if you are allergic to Estracon 0.625mg Tablet or any of its components.

Medical Conditions: Let your doctor know if you have certain medical conditions, including:

  • Fibroids inside the womb
  • Endometriosis (growth of womb lining outside the womb)
  • Excessive thickening of the womb lining (endometrial hyperplasia)
  • Increased risk of blood clots
  • Increased risk of estrogen-sensitive cancer, especially in individuals with a family history of breast cancer
  • High blood pressure
  • Liver, kidney, or heart diseases
  • Fluid retention (oedema)
  • Diabetes
  • Gallbladder stones
  • Migraine or severe headache
  • Systemic lupus erythematosus
  • Epilepsy (fits)
  • Asthma
  • Osteosclerosis (a condition affecting eardrum and hearing)
  • Hypocalcemia (low calcium levels in the blood)
  • High levels of fat in the blood

Risk of Endometrial Hyperplasia and Cancer: Estracon 0.625mg Tablet increases the risk of endometrial hyperplasia and endometrial cancer. To minimize this risk, your doctor may prescribe progesterone in addition to Estracon 0.625mg Tablet.

Pregnancy and Breastfeeding: Inform your doctor if you are pregnant or breastfeeding. Estracon 0.625mg Tablet is generally not recommended for use in pregnant or breastfeeding individuals.

Long-Term Use Precautions: Long-term use of high dosages of Estracon 0.625mg Tablet can potentially increase the risk of various health conditions, including:

  • Heart attack
  • Stroke
  • Blood clots
  • Dementia
  • Breast cancer
  • Uterine cancer

Progestin Use: If you still have your uterus (womb), discuss with your doctor whether taking progestin alongside Estracon 0.625mg Tablet is necessary or recommended.

Storage Conditions

Keep away from children and do not store above 25° C. Store at room temperature.

Frequently Asked Questions (FAQ)

Estracon 0.625mg Tablet may cause weight changes. Estracon 0.625mg Tablet contains 'conjugated estrogen' that regulates metabolism and body weight. However, exercise regularly and eat a well-balanced diet to control body weight. In case of unusual weight gain, consult your doctor.

Estracon 0.625mg Tablet may remain in your body for four to five days.

Estracon 0.625mg Tablet is used to treat menopausal symptoms (such as Osteoporosis, Fungal infections, Itching, Burning, Hot flashes, Vaginal dryness, Vaginal atrophy, Menopausal symptoms, Female hypogonadism, Metastatic breast carcinoma, Ovarian failure, Prostate carcinoma, Primary ovarian failure, Hormone replacement therapy, Oral contraceptives) and to prevent osteoporosis in postmenopausal women

Your doctor decides the dose of Estracon 0.625mg Tablet based on your health condition. It is advised not to take more than the recommended dose.

Estracon 0.625mg Tablet is not a contraceptive method. Pregnancy can occur early in menopause, even during monthly cycles. Consult your doctor for non-hormonal birth control options in such cases.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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