Generic Name: Atorvastatin 20mg
Manufacturer/Distributor: Drug International Ltd.
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Indications of Divastin 20
Divastin 20 is a member of the statin drug class. It lowers cholesterol and lowers the chance of developing heart disease. A fatty substance called cholesterol causes your blood vessels to narrow as it accumulates, which can result in a heart attack or stroke. When taken as directed by a doctor, the medication Divastin 20 is frequently recommended and is thought to be safe for long-term usage.
Pharmacology of Divastin 20
Atorvastatin is a selective HMG-CoA reductase inhibitor. This enzyme is the limiting enzyme responsible for converting HMGCoA to mevalonate, which is the precursor to sterols (including cholesterol). Atorvastatin reduces plasma levels of cholesterol and lipoproteins by inhibiting HMGCoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors on the cell surface to enhance absorption and catabolism of LDL.
Dosage & Administration
Primary hypercholesterolemia and combined hyperlipidemia-
Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 20 mg once daily.
Familial hypercholesterolemia-
Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 80 mg once daily.
Prevention of cardiovascular events-
Adults: Initially 10 mg once daily adjusted according to the response.
Interaction of Divastin 20
The risk of myopathy during Divastin 20 treatment increases with the simultaneous administration of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, and niacin. When atorvastatin was used in combination with antihypertensive drugs or hypoglycemic drugs, no clinically significant interactions were observed. The patient should be closely monitored if atorvastatin is added to digoxin, erythromycin, oral contraceptives, colestipol, antacids, and warfarin.
Contraindications
Divastin 20 should not be given to patients who are allergic to any component of this drug. Divastin 20 is contraindicated for active liver disease or unexplained elevated serum transaminases. It is also contraindicated for patients with a history of serious adverse reactions to previous use of HMGCoA reductase inhibitors.
Side Effects of Divastin 20
Divastin 20 is generally well tolerated. The most common side effects of atorvastatin are constipation, flatulence, indigestion, and abdominal pain. Other side effects include infection, headache, back pain, skin rash, weakness, joint pain, and myalgia.
Pregnancy & Lactation
Pregnancy: Divastin 20 is contraindicated during pregnancy. The safety of pregnant women has not been determined. No controlled clinical trials of atorvastatin have been conducted in pregnant women. Rare reports of birth defects have been received after intrauterine exposure to HMG-CoA reductase inhibitors. Animal studies have shown that it is toxic to reproduction. Treatment of mothers with Divastin 20 may reduce the fetus's mevalonate levels, which is a precursor of cholesterol biosynthesis. Atorvastatin should not be used in women who are pregnant, trying to become pregnant, or are suspected of becoming pregnant. Divastin 20 treatment should be stopped during pregnancy or before it is determined that the woman is not pregnant.
Lactation period: It is unknown whether Divastin 20 or its metabolites are excreted from human milk. In rats, the plasma concentrations of Divastin 20 and its active metabolite are similar to those in milk. Due to the possibility of serious adverse reactions, women taking atorvastatin should not breastfeed their babies. Divastin 20 is contraindicated during lactation.
Precautions & Warnings
Liver effects: Liver function tests should be performed before starting treatment and regularly after treatment. Patients who drink a lot of alcohol or have a history of liver disease should use atorvastatin with caution. If there is a significantly elevated CPK level or myopathy is diagnosed or suspected, atorvastatin treatment should be discontinued.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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