Anzitor 10mg Tablet

✔️ Uses of Anzitor 10mg Tablet

• Treats high blood cholesterol levels
• Prevents the risk of heart attack, stroke, angina, or related health problems

✔️ How does Anzitor 10mg Tablet work?

Anzitor 10mg Tablet is a lipid-lowering medicine. It effectively reduces the levels of bad cholesterol (LDL) and triglycerides in the body by blocking the action of an enzyme called HMG-CoA reductase that synthesizes cholesterol within the body. It also acts on the liver and improves the body’s ability to remove lipid particles from the blood. As a result, it reduces blood cholesterol levels and prevents its associated risks.

✔️ Side Effects of Anzitor 10mg Tablet

Atorvastatin is generally well-tolerated, with most adverse reactions being mild and transient. Rare but significant side effects include reversible myositis, headache, altered liver function tests, and gastrointestinal effects like abdominal pain, flatulence, diarrhea, nausea, and vomiting. Thrombocytopenia, rash, and hypersensitivity reactions are reported infrequently. Other potential side effects encompass insomnia, angioedema, anorexia, asthenia, paresthesia, peripheral neuropathy, alopecia, pruritus, rash, impotence, chest pain, hypoglycemia, and hyperglycemia.

✔️ Quick Suggestions:

• Atorvastatin may cause diarrhea, gas, or an upset stomach. If you experience any of these symptoms, taking it with food can help alleviate them.
• Inform your doctor if you experience fatigue, muscle weakness, or muscle pain while taking Atorvastatin. These symptoms may be associated with a rare but serious side effect called myopathy.
• Your doctor may perform liver function tests before starting treatment with Atorvastatin and regularly thereafter. If you notice signs of liver problems such as stomach pains, unusually dark urine, or yellowing of the skin or eyes, inform your doctor promptly.
• Inform your doctor if you have kidney disease, liver disease, or diabetes before starting treatment with Atorvastatin. If you are diabetic, monitor your blood sugar levels regularly as Atorvastatin may lead to an increase in blood sugar levels.
• Do not take Atorvastatin if you are pregnant, planning a pregnancy, or breastfeeding. It is important to discuss alternative options with your healthcare provider if you fall into any of these categories.

✔️ Indications:

Anzitor is indicated as a supplementary treatment for the reduction of elevated levels of total cholesterol, LDL-cholesterol, apolipoprotein B, and triglycerides in the following patient categories:

1. Primary hypercholesterolemia (heterozygous familial and non-familial hypercholesterolemia) and mixed dyslipidemia (Fredrickson types IIa and IIb).
2. Patients with elevated serum triglyceride levels (Fredrickson type IV).
3. Primary dysbetalipoproteinemia (Fredrickson type III) who do not respond adequately to dietary measures.
4. In the treatment of homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or when such treatments are not available.

✔️ Pharmacology

Anzitor acts as a selective, competitive inhibitor of HMG-CoA reductase, a crucial enzyme responsible for converting 3-hydroxy-3-methyl-glutaryl-coenzyme A into mevalonate, a precursor of sterols, including cholesterol. In the liver, triglycerides (TG) and cholesterol are combined into very low-density lipoprotein (VLDL) and released into the bloodstream for delivery to peripheral tissues. Low-density lipoprotein (LDL) is formed from VLDL and is primarily metabolized through the high-affinity LDL receptor.

Anzitor reduces plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver. It also increases the number of hepatic LDL receptors on cell surfaces, enhancing the uptake and catabolism of LDL. Consequently, Anzitor® decreases LDL production and the quantity of LDL particles while enhancing LDL receptor activity and the quality of circulating LDL particles.

✔️ Dosage & Administration of Anzitor 10mg Tablet

Patients should adhere to a standard cholesterol-lowering diet before initiating Anzitor treatment and continue this diet throughout the course. The usual starting dose for all indications is 10 mg once daily, with doses ranging from 10 to 80 mg once daily. Dosage adjustments should be individualized based on baseline LDL-C levels, therapeutic goals, and patient response. Adjustments may occur at intervals of 4 weeks or longer. Anzitor can be taken at any time of day with or without food.

Children: Limited experience exists with Anzitor at doses up to 80 mg/day in the pediatric population.

Geriatric (>70 years) use: The safety and efficacy of Anzitor in this age group are similar to patients aged <70 years at doses of up to 80 mg/day.

Renal Insufficiency: No dosage adjustment is required.

✔️ Interaction

The risk of myopathy increases when atorvastatin is concurrently administered with cyclosporine, fibric acid derivatives, erythromycin, azole antifungals, and niacin. Combining atorvastatin with antihypertensive or hypoglycemic drugs has not demonstrated clinically significant interactions. However, closely monitor patients when combining atorvastatin with digoxin, erythromycin, oral contraceptives, colestipol, antacids, or warfarin.

✔️ Contraindications

Atorvastatin is contraindicated in patients with hypersensitivity to any component of the medication, active liver disease, unexplained persistent elevations of serum transaminases, during pregnancy, during breastfeeding, and in women of childbearing potential not using appropriate contraceptive measures.

✔️ Pregnancy & Lactation

Atorvastatin is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraceptive measures. If pregnancy occurs while taking atorvastatin, discontinue the medication.

✔️ Precautions & Warnings

Liver function tests should be conducted before initiating treatment with atorvastatin and periodically thereafter. Patients with a history of heavy alcohol consumption or liver disease should use atorvastatin with caution. In the event of a significant increase in CPK levels or the diagnosis or suspicion of myopathy, discontinue atorvastatin treatment.

✔️ Storage Conditions

Store below 25°C, protecting from light and moisture. Keep all medicines out of reach of children.